Sinus and adenoid inflammation in children with chronic rhinosinusitis and asthma

Anfuso, Antony; Ramadan, Hassan H.; Terrell, Andrew M.; Demirdağ, Yeşim Yılmaz; Walton, Cheryl; Skoner, David P.; Piedimonte, Giovanni

doi:10.1016/j.anai.2014.10.024

Cited by 41 publications

(21 citation statements)

References 31 publications

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“…They demonstrated a significant decrease in IL-4 and a significant increase in IFN-γ in allergic study participants, and a significant decrease in IL-4 and a non-significant increase in IFN-γ in non-allergic study participants after the treatment [32]. The inflammatory response in the sinus and adenoid tissues of children with CRS and asthma has been observed as quantitatively amplified by Anfuso et al: children with CRS and asthma had significantly higher sinus levels of TNF-α as well as adenoid levels of epidermal growth factor, eotaxin, fibroblast growth factor-2, growth-related oncogene, and platelet-derived growth factor-AA compared with children with CRS and without asthma [33].…”

Section: Pathophysiological Mechanismsmentioning

confidence: 98%

Rhinosinutis and Asthma in Children

et al. 2018

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Rhinosinusitis and asthma are two comorbid conditions that lead to pathological and clinical diseases affecting the respiratory tract. They are connected by significant anatomical, epidemiological, pathophysiological, and clinical evidence, and also share therapeutic principles. The aim of this review is to provide an updated overview of the existing link between rhinosinusitis and asthma focusing on the pediatric age.

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Section: Pathophysiological Mechanismsmentioning

confidence: 98%

Rhinosinutis and Asthma in Children

et al. 2018

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“…A recently reported study about inflammatory cytokines in pediatric CRS with and without allergies and with and without asthma demonstrated that TNF-a levels were higher in the sinus tissues, and epidermal growth factor, eotaxin, fibroblast growth factor-2, growth-related oncogene, and plateletderived growth factor-AA were higher in adenoid tissues in all children with CRS (without allergy and asthma) compared with the controls[24**] .…”

Section: Anatomy and Pathophysiologymentioning

confidence: 99%

“…The epidemiologic link between CRS and asthma has been suggested by pathophysiologic and therapeutic observations. Histologic studies have shown mast cells and eosinophils both in the nasal mucosa of individuals with allergic rhinitis and in the bronchial mucosa of asthmatics[24], and the exposure of patients with rhinitis to specific allergens triggers eosinophilic infiltration into both nasal and bronchial mucosa. Furthermore, several studies have shown that medical management of CRS improves asthma symptoms and lung function, and that surgical management improves asthma symptoms and reduces emergency visits in children with both conditions.When compared to non-asthmatic children with CRS, Anfuso et al found that the sinus tissue of asthmatic children with CRS showed increased levels for 27 of the 40 inflammatory cytokines tested , but the increase was statistically significant only for TNF-β(p=0.009).…”

Section: Anatomy and Pathophysiologymentioning

confidence: 99%

Pediatric Rhinosinusitis

Badr

Gaffin

Phipatanakul

2016

Curr Treat Options Allergy

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Opinion statement Rhinosinusitis, is defined as an inflammation of the paranasal and nasal sinus mucosae. Chronic rhinosinusitis (CRS)is a common problem in the pediatric age group and the diagnosis and treatment are challenging due to the chronicity and similarity of symptoms with allergic rhinitis and adenoid hypertrophy. Although it is less common than acute rhinosinusitis, CRS is becoming more frequent and significantly affects the quality of life in children and can substantially impair daily function. CRS is characterized by sinus symptoms lasting more than 3 months despite medical therapy. Many factors are involved in the pathogenesis of this disease and include a primary insult with a virus followed bybacterial infection and mucosal inflammation, along with predisposition to allergies. The standard treatment of pediatricacute bacterial rhinosinusitis (ABRS) is nasal irrigation and antibiotic use. Medical treatment of pediatric CRS includes avoidance of allergens in allergic patients (environmental or food) and therapy with nasal irrigation, nasal corticosteroids sprays, nasal decongestants, and antibiotics directed at the most common sinonasalorganisms (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis). Surgical therapy is rarely needed after appropriate medical therapy. Referral to an otolaryngologist and allergy specialist is recommended in case of failure of medical treatment.

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“…[40,3] Adenoidal tissue acts as a bacterial reservoir in children with CRS regardless of their size and removing them improves outcomes [41,24]. Adenoidectomy is highly effective as an initial surgical therapy in children aged up to 6 years, it has been found that the efficiency of this treatment decreases between the age of 6 and 12.…”

Section: Surgerymentioning

confidence: 99%

77 Pediatric Rhinosinusitis

Malekzadeh¹

2015

Otolaryngology Lifelong Learning Manual

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Rhinosinusitis, is defined as an inflammation of the paranasal and nasal sinus mucosae. Chronic rhinosinusitis (CRS)is a common problem in the pediatric age group and the diagnosis and treatment are challenging due to the chronicity and similarity of symptoms with allergic rhinitis and adenoid hypertrophy.Although it is less common than acute rhinosinusitis, CRS is becoming more frequent and significantly affects the quality of life in children and can substantially impair daily function. CRS is characterized by sinus symptoms lasting more than 3 months despite medical therapy. Many factors are involved in the pathogenesis of this disease and include a primary insult with a virus followed bybacterial infection and mucosal inflammation, along with predisposition to allergies.The standard treatment of pediatricacute bacterial rhinosinusitis (ABRS) is nasal irrigation and antibiotic use. Medical treatment of pediatric CRS includes avoidance of allergens in allergic patients (environmental or food) and therapy with nasal irrigation, nasal corticosteroids sprays, nasal decongestants, and antibiotics directed at the most common sinonasalorganisms (Haemophilusinfluenzae, Streptococcus pneumoniae, and Moraxella catarrhalis). Surgical therapy is rarely needed after appropriate medical therapy. Referral to an otolaryngologist and allergy specialist is recommended in case of failure of medical treatment.

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Sinus and adenoid inflammation in children with chronic rhinosinusitis and asthma

Cited by 41 publications

References 31 publications

Rhinosinutis and Asthma in Children

Rhinosinutis and Asthma in Children

Pediatric Rhinosinusitis

77 Pediatric Rhinosinusitis

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