Chronic granulocytic leukaemia/ eosinophilic leukaemia in a dog?

Ndikuwera, J.; Smith, Dale A.; Obwolo, M. J.; Masvingwe, C.

doi:10.1111/j.1748-5827.1992.tb01053.x

Cited by 16 publications

(9 citation statements)

References 16 publications

(8 reference statements)

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“…[8][9][10] One dog with suspected EL showed similar signs but more aggressive organ infiltration and fatal outcome. 18 Additional findings reported in feline HES are fever, pruritis, congestive heart failure, seizures and weakness. 5 In human HES, skin involvement is common, 19 and neurological dysfunction (encephalopathy, peripheral neuropathy, thromboembolic cerebral infarctions) can occur.…”

Section: Discussionmentioning

confidence: 96%

“…One canine EL report described a dog with eosinophilic infiltrates throughout the liver, lungs, kidney, lymph nodes and bone marrow. 18 The eosinophilic infiltrates were of varying There is general agreement that HES can be distinguished from EL by the maturity of eosinophils in peripheral blood, bone marrow and tissues. 6,13 There may be immature eosinophils in the blood, bone marrow, and tissues in HES but these are fewer than in EL.…”

Section: Discussionmentioning

confidence: 96%

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Successful treatment of hypereosinophilic syndrome in a dog

Perkins

Watson

2001

Aust Veterinary J

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An 11-year-old crossbred dog was presented with a history of episodic vomiting, diarrhoea, abdominal discomfort and coughing. These signs had been present for several years. Marked peripheral eosinophilia (10.3 x 10(9)/L) was found. No underlying cause of reactive eosinophilia was apparent. Bone marrow aspiration biopsy showed hyperplasia of the eosinophilic cell line, with some increase in immaturity, although all cells were morphologically normal. There were numerous eosinophils in bronchial wash fluid and eosinophilic infiltrates were evident in biopsies of pancreas, liver, small intestine and colon but not stomach. Hypereosinophilic syndrome was diagnosed. The dog responded well to twice daily treatment with hydroxyurea and prednisolone. Clinical signs are well-controlled 16 months later.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Successful treatment of hypereosinophilic syndrome in a dog

Perkins

Watson

2001

Aust Veterinary J

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“…10,11 Two male Rottweilers with IHES have been described previously. 12,13 One of these Rottweilers was thought to have chronic myelogenous EL based on massive organ infiltration with eosinophils of varying degrees of maturity. 13 The respiratory and GI tracts, spleen, and bone marrow most commonly have been involved in the dogs reported.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Hypereosinophilic Syndrome in 3 Rottweilers

Sykes

Weiss

Buoen

et al. 2001

Veterinary Internal Medicne

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Three Rottweilers with marked peripheral eosinophilia and infiltration of the liver, spleen, lungs, and bone marrow with eosinophils were diagnosed with idiopathic hypereosinophilic syndrome (IHES). Mean serum immunoglobulin E concentrations were markedly high. On cytogenetic analysis, no evidence of karyotypic abnormalities was found in bone marrow aspirates. Despite an extensive search, no underlying cause for the eosinophilia could be identified. In this study, cytogenetic analysis and measurement of serum IgE concentrations were used to differentiate IHES and eosinophilic leukemia.Key words: Cytogenetic analysis; Dogs; Eosinophilic gastroenteritis; Eosinophilic leukemia; Immunoglobulin E; SplendoreHoeppli phenomenon. P eripheral eosinophilia and multiple organ infiltration with eosinophils, without evidence of underlying parasitic, neoplastic, vascular, or allergic disease, have been described frequently in humans and cats, but reports in dogs are rare. In humans, idiopathic hypereosinophilic syndrome (IHES) is defined by sustained (Ͼ6 months) peripheral eosinophilia of Ͼ1,500 cells/L with no apparent etiology and multiple organ involvement. 1 The difference between IHES and eosinophilic leukemia (EL) is controversial, and although molecular techniques may help distinguish these 2 disorders in humans, in some cases differentiation may not be possible.This report describes 3 cases of canine IHES with widely differing clinical presentations. All dogs were Rottweilers, and each had large numbers of eosinophils in blood, liver, spleen, and bone marrow aspirates. Pulmonary involvement was present in 2 dogs and was suspected in the other. Karyotype analysis and measurement of serum immunoglobulin E (IgE) concentrations supported the diagnosis. Case Reports Dog 1A 3-year-old female Rottweiler was referred to the Veterinary Teaching Hospital (VTH; University of Minnesota, St Paul, MN) with a 1-month history of vomiting, severe bloody diarrhea, and weight loss. Physical examination disclosed lethargy, cachexia, mucosal pallor, and abdominal enlargement; moderate ascites was detected by abdominal palpation.A CBC disclosed moderate neutrophilia with a left shift, and marked mature eosinophilia ( Minnesota, 1352 Boyd Avenue, St Paul, MN 55108; e-mail: sykes005@tc.umn.edu. Submitted June 27, 2000; Revised August 9, 2000; Accepted September 22, 2000. Copyright ᭧ . Serum protein electrophoresis (SPE) disclosed decreased albumin (1.3 g/dL, RR 1.7-2.9 g/dL) and ␣-2-macroglobulin (0.38 g/dL, RR 0.41-1.11 g/dL) fractions, but ␥-globulin concentration was within the RR. Mean serum IgE concentration was 658 g/mL (RR Ͻ 50 g/mL). Peritoneal fluid was a serosanguineous, inflammatory exudate, with a total protein concentration of 3.4 g/dL, 31,000 red blood cells (RBC)/L, and 10,000 mature eosinophils/L. No other nucleated cells were present. Fecal flotation and heartworm antigen test results were negative, and results of the urinalysis were unremarkable. Abdominal ultrasound showed diffuse variation in hepatic and splenic echo...

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“…Previous publications report lethargy, inappetence, leukocytosis, anemia, pyrexia, splenomegaly, and thrombocytopenia with canine CML [3,[7][8][9][10]23]. Leukocytosis in previous reports was most commonly because of a neutrophilia with a regenerative left shift [3,[7][8][9]23], although cases with a predominant monocytosis [1,5,24] or significant eosinophilia [10] have been reported. Leukocytosis in previous reports was most commonly because of a neutrophilia with a regenerative left shift [3,[7][8][9]23], although cases with a predominant monocytosis [1,5,24] or significant eosinophilia [10] have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic myeloid leukemia (CML) is rare in the dog and diagnosis is challenging as criteria for veterinary CML are not well established [1][2][3][4][5][6][7][8][9][10][11]. Human CML is considered a chronic myeloproliferative disease that occurs because of a specific chromosomal translocation [4,12].…”

Section: Introductionmentioning

confidence: 99%