Successful treatment of hypereosinophilic syndrome in a dog

Perkins, M; Watson, A. D. J.

doi:10.1111/j.1751-0813.2001.tb10671.x

Cited by 21 publications

(58 citation statements)

References 16 publications

(41 reference statements)

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“…Hence, some cases are a major diagnostic challenge. In our patient, there was no evidence of circulating blasts, and the favorable clinical progress ruled out the possibility of EL (LILLIEHÖÖK et al, 2000;PERKINS;WATSON, 2001;SYKES et al, 2001). …”

Section: Discussionmentioning

confidence: 45%

“…Although there is no specific definition for dogs, the same criteria are generally used for diagnosis (PERKINS; WATSON, 2001;SYKES et al, 2001). In the present case, in addition to persistent peripheral eosinophilia, there was the evidence of abdominal effusion and bone marrow involvement.…”

Section: Discussionmentioning

confidence: 54%

“…Of the reported cases, more than half have been Rottweilers (AROCH et al, 2001;DROUOT et al, 2007;FIGHERA et al, 2004;JAMES;MANSFIELD, 2009;JENSEN;NIELSEN, 1992;NDIKUWERA et al, 1992;PERKINS;WATSON, 2001;SYKES et al, 2001). The Rottweiler is a breed that has a high frequency of eosinophilic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…HES has been described in cats and more rarely in dogs (LILLIEHÖÖK;TEVDTEN, 2003;PERKINS;WATSON, 2001). Any organ can undergo infiltration and subsequent tissue damage by eosinophils with the lung, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract most commonly affected.…”

Section: Introductionmentioning

confidence: 99%

“…Any organ can undergo infiltration and subsequent tissue damage by eosinophils with the lung, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract most commonly affected. As a result the clinical signs of the disease are extremely varied (FIGHERA et al, 2004;PERKINS;WATSON, 2001;SYKES et al, 2001). Rottweilers appear predisposed to the development of eosinophilic disorders, such as eosinophilic meningoencephalitis and HES (BENNET et al, 1997;LILLIEHÖÖK et al, 2000;NDIKUWERA et al, 1992;SYKES et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

Ferian

Bach

Salbego

et al. 2017

SCA

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Eosinophils are cells of the immune system that have several important functions including phagocytosis of microorganisms, antigen presentation, contribution to chronic inflammation, and immunity against parasites. The hypereosinophilic syndrome (HES) is a rare disease in humans that is characterized by persistent eosinophilia (over six months) and variable eosinophil infiltration in organs such as the lungs, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract. Once in the tissues, these cells can cause damage by various mechanisms such as release of cytotoxic oxygen free radical and proteins. No etiology has yet been established for HES. The clinical signs vary and relate to the organs involved. In veterinary medicine, the disease has been described in cats, but rarely in dogs, with Rottweilers apparently more predisposed to developing the disease. Owing to the small number of cases reported in the veterinary literature, the prognosis of this disease and the most appropriate treatment options are unclear. Although it can be fatal in animals showing severe clinical symptoms, spontaneous remission may also occur. This study reports a case of HES in a Rottweiler in which the predominant clinical sign was abdominal effusion. We discuss the clinical and laboratory aspects of the disease. Key words: Abdominal effusion. Dog. Eosinophils. ResumoOs eosinófilos são células do sistema imunológico que tem importantes funções, tais como fagocitose de micro-organismos, apresentação de antígenos, contribuição para a cronicidade do processo inflamatório e imunidade contra parasitas. A síndrome hipereosinofílica (SHE) é uma enfermidade rara que acomete seres humanos, caracterizada por eosinofilia periférica persistente (acima de seis meses) e infiltração variável de eosinófilos em diferentes órgãos, como pulmão, baço, fígado, linfonodos, medula óssea e o trato gastrointestinal. Uma vez nos tecidos, essas células causam danos por diversos mecanismos, como liberação de proteínas citotóxicas e radicais livres de oxigênio. Não é possível identificar uma etiologia nos casos de SHE. Os sinais clínicos são variáveis, e diretamente relacionados com os órgãos acometidos. Em medicina veterinária, a moléstia já foi descrita em felinos, mas raramente em cães, sendo que animais da raça Rottweiler são mais predispostos ao desenvolvimento da doença. Em função do pequeno número de casos descritos na literatura veterinária, a evolução da doença e as opções mais apropriadas de tratamento são pouco conhecidas. Embora alguns animais apresentem sinais clínicos graves, podendo evoluir para o óbito, a remissão espontânea também pode ocorrer. O presente trabalho tem por objetivo relatar um caso de SHE com sinal clínico predominante de efusão abdominal em um filhote de cão da raça Rottweiler, abordando aspectos clínicos e laboratoriais da enfermidade. Palavras-chave: Cão. Efusão abdominal. Eosinófilos.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

Ferian

Bach

Salbego

et al. 2017

SCA

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Idiopathic hypereosinophilic syndrome in a cheetah (Acinonyx jubatus)

Clayton¹,

Petite

Rambaud³

et al. 2022

Vet Record Case Reports

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A 10‐year‐old male cheetah (Acinonyx jubatus) presented with weight loss, inappetence and weakness. Clinical examination revealed muscle loss, splenomegaly and dehydration. Haematology and biochemistry showed hyperglobulinaemia and marked leukocytosis with eosinophilia and neutrophilia. Urinalysis revealed proteinuria. Following an empirical 7‐day course of clavulanate potentiated amoxicillin, normal appetite and demeanour were observed. One month later, it re‐represented with the same clinical signs. Clinical examination was repeated. Radiographs showed ileocaecocolic junction dilation. Ultrasound examination revealed enlarged mesenteric lymph nodes, splenic nodules and colonic thickening. Fine‐needle aspirates of these organs and bone marrow aspirates showed marked atypical eosinophilic infiltration with haematology showing peripheral eosinophilia. Idiopathic hypereosinophilic syndrome was diagnosed. Treatment with prednisolone was initiated with good compliance, but there was a marked clinical deterioration 2 days later, and euthanasia was elected on welfare grounds.

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Disorders of Bone Marrow

Harvey

2001

Atlas of Veterinary Hematology

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Successful treatment of hypereosinophilic syndrome in a dog

Cited by 21 publications

References 16 publications

Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

Idiopathic hypereosinophilic syndrome in a rottweiler: a case report

Idiopathic hypereosinophilic syndrome in a cheetah (Acinonyx jubatus)

Disorders of Bone Marrow

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