Chronic Exercise Affects Vitamin B-6 Metabolism but Not Requirement of Growing Rats , ,

Abstract

The effect of chronic exercise (forced swimming) on vitamin B-6 status and metabolism was studied in growing male rats fed deficient (0 mg pyridoxine-HCl/kg), suboptimal (2 mg pyridoxine-HCl/kg) or control (7 mg pyridoxine-HCl/kg) diets for 9 wk. Sedentary rats were fed the same diets. Body weight gain was lower in deficient rats than in both other dietary groups. Sedentary rats were heavier than trained rats of all diet groups. Erythrocyte aspartate aminotransferase, urinary 4-pyridoxic acid excretion, blood (plasma and erythrocytes) and tissue B-6 vitamers were measured. Urinary 4-pyridoxic acid, plasma pyridoxal 5'-phosphate and erythrocyte aspartate aminotransferase values of exercised and sedentary rats responded to changes in dietary pyridoxine but were not different from one another. After 9 wk of vitamin B-6 depletion, tissue concentrations of pyridoxal 5'-phosphate and pyridoxamine 5;5'-phosphate were 41-66% and 26-49% lower, respectively, in the deficient groups than in the control groups. Larger percentage differences occurred in plasma than in tissues (95 vs. 22-66%). In liver, pyridoxal 5'-phosphate concentrations were lower, whereas pyridoxal concentrations were higher in trained than in sedentary rats. In gastrocnemius muscle, pyridoxal 5'-phosphate, pyridoxamine 5'-phosphate and total vitamin B-6 concentrations were higher in trained than in sedentary rats. Concentrations of vitamin B-6 compounds in heart, kidneys, brain and adrenals were not affected by training. On the basis of the vitamin B-6-dependent variables measured in this study, we conclude that prolonged exercise affects the metabolism of vitamin B-6, but does not increase the vitamin B-6 requirement in growing rats.

Experimental immunology The effect of vitamin B 6 supplementation of protein deficiency diet on hematological parameters in the blood of rats subjected/non subjected to physical exertion – a pilot study

“…Several authors revealed changes in B 6 concentration and metabolism induced physical exercise [21,22]. However, they also indicated that this change does not increase the vitamin B 6 requirement of growing rats [23]. In this study, we didn't notice statistically significant differences of body mass and feed consumption between trained and non-trained rats among the same dietary group.…”

Effects of training versus short exercise session on homocysteine levels in women with different body mass

“…According to Hadj-Saad et al [46], vitamin B 6 levels in the blood increase after 1 hour of an intensive swimming exercise in rats as due to its being shifted from a muscle deposit pool, however, levels decrease after 9-weeks of training [47]. Vitamin B 6 is responsible for protein and amino acid metabolism and a cofactor for many enzymes participating in amino acid transformation.…”

Effect of Exercise on the Metabolism of Vitamin B6 and Some PLP-dependent Enzymes in Young Rats Fed a Restricted Vitamin B6 Diet.

“…It has been known that, by exercise, the synthe sis and the degradation of muscle protein increase, and glycogenolysis is stimulated. Hadi-Saad et al (1) have suggested that prolonged exercise affects the metabo lism of vitamin B6, but does not increase vitamin B6 re quirements in growing rats. They observed that physi cal exertion resulted in an increase in urinary 4-pyri doxic acid (4-PA) excretion and some alterations in the forms of B6 vitamers contained in the tissues in a state of physical exertion, but no alteration in the quantity of B6.…”