Experimental immunology The effect of vitamin B 6 supplementation of protein deficiency diet on hematological parameters in the blood of rats subjected/non subjected to physical exertion – a pilot study

Lewicka, Aneta; Lewicki, Sławomir; Zdanowski, Robert; Rutkowski, Piotr; Turkowska, Monika; Kłos, Anna; Bertrandt, Jerzy

doi:10.5114/ceji.2012.30791

Cited by 9 publications

(12 citation statements)

References 24 publications

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“…In the present study, protein malnutrition (4.5% of protein) had a negative impact on hemoglobin, MCV and MCH parameters (all of them were lower). The results are consistent with the work of other researchers and with our previous study (Lewicka et al, 2012). Pyridoxine is involved in the proper functioning of the haematological system.…”

Section: Discussionsupporting

confidence: 94%

“…The addition of vitamin B6 (300% of norm) inhibits the negative influence of protein malnutrition. These data are consistent with our previously published study (Lewicka et al, 2012). Rodríguez-Rodríguez et al (2008) showed that vitamin B6 lessens the negative effect of hypocaloric diet and helps maintaining fat-free mass in overweight/obese women.…”

Section: Discussionsupporting

confidence: 93%

“…We previously described that B6 supplementation exhibited a protective effect in growing rats fed for a short period of time (30 days) with the protein-deficient diet (Lewicka et al, 2012). Vitamin B6 improved body weight and food intake and selected morphological parameters in rat blood.…”

Section: Introductionmentioning

confidence: 96%

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The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

Lewicki

Leśniak

Bertrandt

et al. 2018

Food and Agricultural Immunology

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

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The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

Lewicki

Leśniak

Bertrandt

et al. 2018

Food and Agricultural Immunology

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“…Long-term consumption of a protein-deficient diet reduces body temperature in humans and animals, causing hypoalbuminemia, edema formation, damage of blood vessels and liver [ 3 , 4 ]. It has been shown that a protein-deficient diet decreased the level of hemoglobin, hematocrit, mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in rats [ 6 ]. It also attenuates the immune system function.…”

Section: Introductionmentioning

confidence: 99%

Experimental immunology The influence of vitamin B 12 supplementation on the level of white blood cells and lymphocytes phenotype in rats fed a low-protein diet

Lewicki¹,

Lewicka²,

Kalicki³

et al. 2014

cejoi

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Protein malnutrition has a negative effect on body composition and some blood parameters, especially in the young growing organism. One of nutritional factors which could protect against negative consequences of protein deficiency may be B group vitamins. The aim of the study was to investigate the effect of vitamin B12 supplementation on the immune system in rats fed a standard and a low-protein diet. Rats were fed a control (20% of energy from protein) or a protein-deficient diet (4.5% of energy from protein). Half of animals in each group were additionally supplemented with vitamin B12 (300% of the daily intake). The white blood cells analysis and lymphocytes immunophenotyping (number and percentage) were performed. Low-protein diets caused disturbances in WBC and lymphocyte subpopulations in both short- (30-day) as well as long-term periods (90-day). Vitamin B12 supplementation significantly reduced the negative impact of protein malnutrition after 30 days, however had no effect on long-term malnutrition. Furthermore, vitamin B12 addition in rats fed a control diet did not affect the studied parameters. This observation opens the promise of use of vitamin B12 supplementation to improve immune system parameters in protein malnourished organisms.

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“…It was noticed that physical training also affects some haematological parameters. An increase in mean corpuscular haemoglobin (MCV) and decrease in mean corpuscular haemoglobin concentration (MCHC) in rats was also observed [9]. Dosed physical exercise, especially with an appropriately chosen diet, additionally affected the composition and content of fatty acids (FA) in body fluids and tissues.…”

Section: Introductionmentioning

confidence: 99%

Influence of protein deficient diet, vitamin B<sub>2</sub> supplementation and physical training on serum composition of polyunsaturated fatty acids (PUFAs) in rats

Lewicka

Lewicki

Kłos

et al. 2017

Ann Agric Environ Med.

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[b]Introduction[/b]. Prolonged shortages of protein in the diet significantly alter the composition and content of polyunsaturated fatty acids (PUFA) in tissues and body fluids. One of nutritional factors which may reduce negative effects of protein malnutrition might be vitamin B[sub]2[/sub] due to its influence on lipids metabolism. [b]Objective. [/b]The aim of the study was to investigate the influence of low protein (LP) diet enriched with vitamin B[sub]2[/sub] on the content and composition of PUFA in the blood serum of rats treated with dosed physical exercise. [b]Materials and method. [/b]The experiment was carried out for 3 months on 72 growing male Wistar rats divided into 5 groups. Animals were fed ad libitum on a diet with an energy value of 350 kcal/100 g, in which 4.5% of the energy was provided by protein. In the control diet, 20% of the energy was provided by protein. Two groups were fed the diet enriched with vitamin B2. The two groups of tested animals were trained for 5 days a week. [b]Results.[/b] LP diet caused a decrease in α-linolenic acid (ALA) after 30 days, and a decrease in docosahexaenoic acid (DHA) after 60 days of experiment, compared with rats fed the control diet. After 60 and 90 days of the experiment, a significant decrease was noted in arachidonic acid (AA) in serum of trained rats, compared with sedentary rats fed the LP diet. Physical activity increased LA (mainly on day 30), EPA (on day 90) and reduced AA content (on day 90) in serum of rats fed the LP diet. B2 supplementation in the trained LP group did not change the EPA and AA dependence; however, there was a decrease in LA content in comparison to the non-supplemented trained group. [b]Conclusions. [/b] Results of this study suggest that all investigated factors (protein deficiency, physical exercise and supplementation of vitamin B2) have significant impact on PUFA composition of serum in rats.

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Experimental immunology The effect of vitamin B 6 supplementation of protein deficiency diet on hematological parameters in the blood of rats subjected/non subjected to physical exertion – a pilot study

Abstract: Abstract

Cited by 9 publications

References 24 publications

The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

Experimental immunology The influence of vitamin B 12 supplementation on the level of white blood cells and lymphocytes phenotype in rats fed a low-protein diet

Influence of protein deficient diet, vitamin B<sub>2</sub> supplementation and physical training on serum composition of polyunsaturated fatty acids (PUFAs) in rats

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