The study aimed at determining the effect of melatonin on the activity of protective antioxidative enzymes in the heart and of lipid peroxidation products in the course of intoxication with doxorubicin (DOX). The rats were categorized into four groups, receiving: 0.9% NaCl i.p. (NaCl control); melatonin [20 mg/kg body weight (b.w.)] s.c. (control Mel); DOX (2.5 mg/kg b.w.) i.p.; melatonin plus DOX in doses as above. All the substances were administered once in a week for four consecutive weeks. Homogenates of heart tissue were examined for activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), levels of reduced glutathione (GSH) and of lipid peroxidation indices (MDA + 4-HDA). Administration of melatonin alone did not induce alterations in levels of MDA + 4-HDA, GSH, or in activity of GPx, SOD or CAT, as compared to the group receiving 0.9% NaCl. GSH levels decreased following DOX but remained at normal levels following DOX and melatonin. The level of MDA + 4-HDA increased following DOX, as compared with the control, a change prevented by the combination of DOX + melatonin. Activities of GPx, SOD and CAT were higher in groups receiving DOX and/or DOX plus melatonin than in control groups. Activity of CAT and the level of GSH in the group receiving DOX plus melatonin were significantly higher than in the group intoxicated with DOX alone. The obtained results demonstrate that, when given in parallel with DOX, melatonin protects cardiomyocytes from damaging effects of the cytostatic drug (reflected by the levels of MDA + 4-HDA). The protective effect resulted, in part from the augmented levels of GSH and from stimulation of CAT activity by melatonin in cardiomyocytes subjected to the action of DOX.
Fundamental motor skills (FMS) are the basic elements of more complex sport-specific skills and should be mastered at the end of early childhood; however, the relationship between FMS and sport-specific skills has not yet been verified in prepubertal soccer players. Therefore, the aim of this study was to determine the role of FMS in the process of acquiring soccer-specific motor skills (measured using speed dribbling) with regard to physical fitness and biological maturation. Forty male soccer players (11.5 ± 0.3 years of age) at the highest performance level participated in the study. The test of Gross Motor Development – second edition and Unifittest 6–60 were used to assess FMS and physical fitness, respectively. The role of FMS in a complex theoretical model with the relationships between physical fitness, biological maturation and speed dribbling was analyzed by multiple regression path analyses (MRPA). Moderate to strong correlations were found between FMS, physical fitness, and speed dribbling ( r = 0.56–0.66). Biological maturation did not appear to be a significant predictor of physical fitness or speed dribbling. The MRPA model using FMS as mediator variable between physical fitness and speed dribbling showed a significant indirect effect (standard estimation = −0.31, p = 0.001; R 2 = 0.25). However, the direct correlation between physical fitness and speed dribbling was non-significant. Our results showed that FMS significantly strengthened the influence of physical fitness on the performance of speed dribbling, a soccer-specific motor skill, and thus play an important role in the process of acquiring sport-specific motor skills in prepubertal soccer players. When considering the long-term training process, especially during childhood and before puberty, a wide range of FMS activities should be applied for better and possibly faster acquisition of soccer-specific motor skills.
This study aimed to investigate the effects of the 6-week small-sided games training (SSGs) vs. high-intensity interval training (HIIT) on the psychophysiological and performance responses, and technical skills of young basketball players. Thirty-two male players (age: 14.5 ± 0.5 years of age) were randomly divided into SSGs group (n = 16) and HIIT group (n = 16) training methods thrice per week for 6 weeks. The players in the SSGs group performed two 5–8 min of 2 vs. 2 with 2 min rest periods, while the players in HIIT performed 12–18 min of runs at intensities (90 to 95%) related to the velocity obtained in the 30-15 intermittent fitness test (IFT). Pre-testing and post-testing sessions involved assessments of Yo-Yo Intermittent Recovery Test level 1, 30-15 intermittent fitness test, 5 and 30 m sprint times, vertical jump height, repeated sprint ability, defensive and offensive agility, and technical skills. The SSGs group demonstrated significantly higher agility-based technical responses in terms of the control dribbling and shooting skills (d = 1.71 vs. 0.20, d = 1.41 vs. 0.35, respectively) compared with the HIIT group. Conversely, the HIIT induced greater improvements in 30 m sprint times (d = 3.15 vs. 0.68). These findings provided that SSGs in youth basketball players may allow similar positive physical adaptations to HIIT, with an extra advantage of improving technical skills while improving enjoyability.
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