Chronic cutaneous lupus erythematosus—clinical spectrum

Pramatarov, Kyrill

doi:10.1016/j.clindermatol.2003.12.016

Cited by 23 publications

(18 citation statements)

References 26 publications

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“…The literature contains conflicting reports regarding the possibility of tumid LE occurring simultaneously with SLE or other forms of cutaneous LE (2,12). Although the association with systemic disease is low, there have been a number of documented reports of tumid LE coexisting with either DLE or SLE (1,3,4,5).…”

Section: Commentmentioning

confidence: 99%

Coexistence of Tumid Lupus Erythematosus With Systemic Lupus Erythematosus and Discoid Lupus Erythematosus

Stead

Headley²,

Ioffreda³

et al. 2008

JCR: Journal of Clinical Rheumatology

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Tumid lupus erythematosus is a rare variant of chronic cutaneous lupus erythematosus that is characterized clinically by smooth, nonscarring, pink to violaceous papules or plaques without evidence of surface change. Histopathologic features include superficial and deep lymphocytic infiltration in a perivascular and periadnexal distribution, with dermal interstitial mucin deposition and focal or absent dermoepidermal junction involvement. These clinical and histopathologic features can be challenging to differentiate from other cutaneous diseases. This is particularly true because patients with tumid lupus erythematosus usually do not have other manifestations of systemic lupus erythematosus or cutaneous lupus erythematosus. We present two cases of tumid lupus erythematosus, one associated with concomitant systemic lupus erythematosus and the other occurring concurrently with discoid lupus erythematosus. Furthermore, we demonstrate the rare occurrence of a patient with tumid LE occurring below the waist at a photoprotected site.

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Section: Commentmentioning

confidence: 99%

Coexistence of Tumid Lupus Erythematosus With Systemic Lupus Erythematosus and Discoid Lupus Erythematosus

Stead

Headley²,

Ioffreda³

et al. 2008

JCR: Journal of Clinical Rheumatology

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“…Entretanto, até o momento, sua etiologia não é completamente elucidada. [1][2][3] Caracteriza-se classicamente por pápulas e placas eritematosas, infiltradas, que evoluem com atrofia central, descamação e formação de espículas córneas. 2 Acomete principalmente áreas fotoexpostas da face, região cervical e membros superiores, mas também couro cabeludo, pavilhão auricular, mucosas e extremidades.…”

Section: Introductionunclassified

“…[1][2][3] Caracteriza-se classicamente por pápulas e placas eritematosas, infiltradas, que evoluem com atrofia central, descamação e formação de espículas córneas. 2 Acomete principalmente áreas fotoexpostas da face, região cervical e membros superiores, mas também couro cabeludo, pavilhão auricular, mucosas e extremidades. 1,2,4 Formas crônicas cutâneas ocorrem, com maior frequência, na faixa entre 20 e 40 anos de idade.…”

Section: Introductionunclassified

“…2 Acomete principalmente áreas fotoexpostas da face, região cervical e membros superiores, mas também couro cabeludo, pavilhão auricular, mucosas e extremidades. 1,2,4 Formas crônicas cutâneas ocorrem, com maior frequência, na faixa entre 20 e 40 anos de idade. Há predomínio de acometimento no sexo feminino, na proporção de 2-3:1, sem predileção por raça.…”

Section: Introductionunclassified

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Grupos sanguíneos e lúpus eritematoso crônico discoide

Tamega

Bezerra

Pereira

et al. 2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS: Lesão discoide é a manifestação cutânea mais comum do lúpus eritematoso, e formas cutâneas crônicas apresentam características imunológicas próprias, direcionadas ao polo Th1. Diversas doenças possuem associação com grupos sanguíneos, o que não foi ainda estudado no lúpus discoide. OBJETIVO: Investigar a associação entre tipos sanguíneos (ABO e Rh) e lúpus eritematoso discoide. MÉTODOS: Estudo prospectivo tipo transversal envolvendo tipagem sanguínea ABO e Rh, inquérito de dados clínicos e dosagem de FAN e C4 de portadores de lúpus discoide sem critérios de doença sistêmica, atendidos em hospital universitário. RESULTADOS: Foram incluídos no estudo 69 pacientes, sendo 71,0% do sexo feminino (p < 0,01). A idade do surgimento da doença foi de 32,8 ± 13,1 anos. Formas disseminadas ocorreram em 47,8%; história de tabagismo foi verificada em 59,4%; FAN > 1:160, em 31,9%; e níveis baixos de C4, em 8,7%. Não houve diferença significativa entre as frequências dos grupos sanguíneos dos pacientes e da população local; entretanto, o grupo A foi associado às formas disseminadas da doença (OR 4,1 e p < 0,05). CONCLUSÕES: Grupos sanguíneos de pacientes com lúpus discoide apresentam frequência semelhante à da população; porém, formas clínicas disseminadas foram mais prevalentes entre portadores do grupo A. Palavras-chave: Epidemiologia; Lúpus eritematoso discoide; Sistema do grupo sanguíneo ABO; Sistema do grupo sanguíneo Rh-Hr Abstract: BACKGROUND: Discoid lesion is the commonest cutaneous finding in lupus erythematosus and chronic types have their own immunological features, with Th1 inflammation profile. Although many diseases have association with blood-group systems, this fact was not enlightened in discoid lupus erythematosus. OBJECTIVE: To investigate the association between blood groups (ABO and Rh) and discoid lupus erythematosus. METHODS: A prospective cross-sectional study assessing clinical information, blood group systems (ABO and Rh), FAN and C4 serum levels from discoid lupus patients without characteristics of systemic disease, was carried out at a clinic from a Brazilian university hospital. RESULTS: Sixty-nine patients were enrolled in the study, 71.0% were females (p<0.01), mean age of disease onset was 32.8±13.1 years, and disseminate form occurred in 47.8%, smoking was related in 59.4%, FAN>1:160 in 31.9%, and low levels of C4 in 8.7%. There was no significant difference between the frequency of blood groups from discoid lupus patients and local population, however, blood group A was associated to disseminate forms of the disease (OR 4.1 and p <0.05). CONCLUSIONS: Discoid lupus erythematosus patients with ABO and Rh blood groups exhibit similar frequencies as in the general population; nevertheless, disseminate clinical forms were more prevalent among group A patients.

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“…10 Cases are classified as lymphocytic, neutrophilic or mixed (Table 1). 5,6,9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In end-stage disease, in which the infiltrate is no longer detectible, the condition is said to be "burned out," and no further classification is possible.…”

Section: How Is Primary Cicatricial Alopecia Classified?mentioning

confidence: 99%

Primary cicatricial alopecia: diagnosis and treatment

Filbrandt

Rufaut

Jones

et al. 2013

CMAJ

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Review CMAJ• Inflammation that destroys the bulge of the outer root sheath destroys the hair follicle and leads to cicatricial alopecia.• Primary cicatricial alopecia is an inflammatory disorder of unknown cause that leads to irreversible hair loss.• The natural history is for the alopecia to extend slowly over the scalp and eventually burn out. The rate of extension and the final severity are extremely variable and difficult to predict.• A number of treatments are used empirically; however, they are not supported by data from clinical trials.

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Chronic cutaneous lupus erythematosus—clinical spectrum

Cited by 23 publications

References 26 publications

Coexistence of Tumid Lupus Erythematosus With Systemic Lupus Erythematosus and Discoid Lupus Erythematosus

Coexistence of Tumid Lupus Erythematosus With Systemic Lupus Erythematosus and Discoid Lupus Erythematosus

Grupos sanguíneos e lúpus eritematoso crônico discoide

Primary cicatricial alopecia: diagnosis and treatment

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