Primary cicatricial alopecia: diagnosis and treatment

Filbrandt, Rebecca; Rufaut, Nicholas W; Jones, Leslie; Sinclair, Rodney

doi:10.1503/cmaj.111570

Cited by 59 publications

(58 citation statements)

References 39 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Next, a possible recruitment bias is also conceivable with regard to the gender ratio. While in the present study the gender ratio was about 0.9: 1, higher prevalence rates of LPP are normally observed in females [3]. Lastly, a longitudinal design would have allowed observation of the causal relationships between further development of LPP and changes and stability of symptoms of depression and anxiety.…”

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

et al. 2019

View full text Add to dashboard Cite

Background: Individuals with lichen planopilaris (LPP) typically present with hair loss and an irritated scalp, with signs and symptoms such as itching, erythema, scaling, and burning. Both hair loss and reddened skin may be visible also for other people. Therefore, it is conceivable that individuals with LPP might report a lower mental health status. Accordingly, in the present study, we compared dimensions of mental health between individuals with LPP and healthy controls. Method: A total of 38 individuals with LPP (mean age: 38.24 years, 47.4% females) and 58 gender- and age-matched controls took part in this study. They completed questionnaires covering dimensions of quality of life and self-esteem; experts rated participants’ symptoms of depression and anxiety. Furthermore, dermatologists reported on the illness duration, the LPP activity index, and the severity of alopecia. Results: Compared to healthy controls, individuals with LPP reported lower scores of self-esteem, physical functioning, and mental health and higher scores of role limitations (physical and emotional). Likewise, experts rated higher depression scores in individuals with LPP compared to controls. In individuals with LPP, a higher LPP disease activity and a higher severity of hair loss were associated with higher depression and lower quality-of-life scores. Further, a higher LPP activity index, a lower self-esteem, and higher anxiety scores predicted a poorer quality of life, while illness duration was statistically unrelated. Conclusions: Compared to controls, and irrespectively of the illness duration, individuals with LPP reported a lower quality of life and a lower self-esteem, and experts’ ratings observed higher scores of depression. Experts treating individuals with LPP might pay special attention to the individuals’ mental health status.

show abstract

Section: Discussionmentioning

confidence: 74%

“…In androgenetic alopecia (male pattern baldness) and alopecia areata the hair follicle bulbs are not destroyed, but the follicles are able to regenerate and hair regrowth might be possible with appropriate treatments [3]. By contrast, in PCA the hair follicle is irreversibly destroyed and replaced by fibrous tissue [3].…”

Section: Introductionmentioning

confidence: 99%

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

et al. 2019

View full text Add to dashboard Cite

show abstract

“…2 years of full stability of the disease, during which it was not necessary to apply any kind of therapy maintaining the remission. If the disease process in the pseudopelade is stable, it is possible to conduct hair transplantation because no other therapeutic methods exist [1, 12, 37–46]. …”

Section: Psychic Disturbances Concerning the Hairmentioning

confidence: 99%

Hair diseases: a big problem on a small surface

Brzeźińska-Wcisło¹,

Wcisło‐Dziadecka²

2016

pdia

View full text Add to dashboard Cite

Civilizational progress initially contributes to the problem of hair loss and then to alopecia as regards both frequency and therapeutic dilemmas. The work presents trichological problems which occur more rarely, i.e. drug-induced, anagen and telogen alopecia, congenital and acquired structural hair disorders, psychic disturbances concerning the hair as well as the hair during menopause. Then, the article briefly describes contagious (infectious) diseases as well as diseases with inflammatory etiology which are accompanied by exfoliation and (frequently) pruritus. Finally, alopecia cicatricans is discussed. Alopecia areata and androgenetic alopecia are omitted herein because they occur more often and will be described in another work. Any disproportions and upset balance concerning correct functioning of mechanisms within the scalp hair system are the evidence of pathologies.

show abstract

“…Primary scarring alopecias are generally subdivided into three categories: lymphocytic (lichen planopilaris [LPP], frontal fibrosing alopecia [FFA], central centrifugal cicatricial alopecia [CCCA], and pseudopelade of brocq), neutrophilic (folliculitis decalvans, tufted folliculitis, and dissecting cellulitis), and mixed lymphocytic/neutrophilic (folliculitis keloidalis, folliculitis necrotica, and erosive pustular dermatosis) [1]. Primary scarring alopecia are more common in women, who present typically in ages between 30 and 50 years [2]. Though the exact pathogenesis of primary scarring alopecia differ among particular diagnoses, the predominant similarity is that immune cells permanently DOI: 10.1159/000492539 damage the follicular stem cell reservoir of the outer root sheath, or bulge region, of hair follicles [3].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

Ekelem

Pham

Mesinkovska³

2018

Skin Appendage Disord

View full text Add to dashboard Cite

Importance: Hair loss, or alopecia, is one of the most commonly presented problems in dermatology. Scarring alopecias are considered particularly damaging due to limited success in slowing permanent disease progression, and current treatment methods, such as intralesional and topical steroids and topical minoxidil, are largely ineffective. Objective: Hair transplantation is a debated treatment option for advanced cases of primary scarring alopecia. This study reviews the efficacy of hair transplantation as a treatment option for primary scarring alopecia. Evidence Review: A primary literature search was conducted using PubMed to identify articles in scarring alopecia and hair transplants published from 1960 to the present time. Findings: Fifteen reports with 34 patients were included in this review. Twenty six patients experienced moderate to positive results, while 8 patients experienced negative results or recurrence of disease. Positive hair transplantation results have been reported in patients with central centrifugal cicatricial alopecia, en coup de sabre, discoid lupus erythematous, pseudopelade de brocq, and folliculitis decalvans. Positive and negative results were observed in patients with lichen planopilaris and frontal fibrosing alopecia. Conclusion and Relevance: Findings show that hair transplant surgery can be considered as a treatment option for certain primary scarring alopecias. However, data must be interpreted with caution due to concern for positive-result publication bias.

show abstract

Primary cicatricial alopecia: diagnosis and treatment

Cited by 59 publications

References 39 publications

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

Hair diseases: a big problem on a small surface

A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

Contact Info

Product

Resources

About