Chromanone-type compounds from marine sponge-derived Daldinia eschscholtzii KJMT FP 4.1

doi:10.7324/japs.2020.101001

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…These fungi are well known as potential producers of unique bioactive compounds with diverse biological properties (Imhoff 2016;Indraningrat et al 2016). Our previous works successfully isolated some interesting novel compounds from Indonesia's spongeassociated fungi, such as karimunone A-B, karimanone, and penicitrinone G Sabdaningsih et al 2020;Sibero et al 2020). In addition to the potential for biotechnology, the study of biodiversity of spongeassociated fungi from Indonesia has been neglected and has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Diversity of sponge-associated fungi from a mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia

et al. 2021

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Abstract. Sibero MT, Pribadi R, Larasati SJH, Calabon MS, Sabdono A, Subagiyo S, Frederick EH. 2021. Diversity of sponge-associated fungi from a mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia. Biodiversitas 22: 5695-5605. Plenty of studies have reported interesting biological properties and bioactive compounds from sponge-associated fungi in Indonesia. However, only a few studies consider their biodiversity. Most of the studies collected the sponge from the coral reef ecosystem and barely reported from the mangrove ecosystem. This study aimed to discover the biodiversity of sponge-associated fungi from a mangrove ecosystem using a DNA barcoding approach. Five mangrove-associated sponges were collected from a tidal mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia. In total, we isolated 56 sponge-associated fungi, which consisted of seven genera in the phylum Ascomycota (77.78%), one genus in the phylum Basidiomycota (11.11%), and one genus in the phylum Mucoromycota (11.11%). Trichoderma (n: 15, 26.79%), Aspergillus (n: 13, 23.21%) and Fusarium (n: 12, 21.45%) were the top three dominant genera. In addition, based on the association of fungi to its sponge hosts, Aspergillus, Aureobasidium, Fusarium, and Trichoderma are sponge-generalists; Absidia and Pestalotiopsis are sponge-associates; while Lasiodiplodia, Montagnula, and Wallemia are sponge-specialist.

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Section: Introductionmentioning

confidence: 99%

Diversity of sponge-associated fungi from a mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia

et al. 2021

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“…7) (v/v). All fractions were collected for evaporation at 30-35 °C (Sibero et al 2019;Sibero et al 2020c). The extraction gave 2.75 g of crude extract.…”

Section: Fractionation Of Rhizophora Apiculata Metabolitementioning

confidence: 99%

Ethnomedicinal bioprospecting of Rhizophora apiculata leaves through in silico and in vitro approaches as antioxidant, ?-glucosidase inhibitor and anticancer

et al. 2022

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Abstract. Sibero MT, Pribadi R, Ambariyanto A, Haryanti D, Kharisma VD, Dewi AS, Patantis G, Zilda DS, Murwani R. 2022. Ethnomedicinal bioprospecting of Rhizophora apiculata leaves through in silico and in vitro approaches as antioxidant, a-glucosidase inhibitor and anticancer. Biodiversitas 23: 6437-6447. Investigating marine natural products for biopharmaceutical development leads to a massive study of mangrove metabolites. Rhizophora apiculata is utilized as a traditional medicine by the local community in Indonesia. However, only a few studies reported the lead compounds. The aim of this study was to discover the biological properties of R. apiculata metabolites from the leaves as an antioxidant, a-glucosidase inhibitor, and anticancer agent through in vitro and in silico approaches. The leaves of R. apiculata were extracted and then fractionated using the silica-OCC method. All fractions were screened for antioxidant, a-glucosidase inhibitors, and cytotoxicity assays. Then the bioactive compounds in prospective fractions were identified using LC-HRMS. The selected compounds with ppm error <10 were applied for in silico analysis. The result of biological properties screening indicated Fr. 5 and Fr. 6 as the most potent sources of antioxidants, a-glucosidase inhibitors, and cytotoxic compounds. In total, 19 compounds were selected from two prospective fractions. The drug-likeness and bioavailability prediction results indicated that all selected compounds act as drug-like molecules. In addition, 17 were predicted to have antioxidant activity, and 15 compounds had antidiabetic activity. Moreover, 15 compounds had a more negative affinity binding than cytarabine. Molecular docking analysis showed that the mechanism of cytotoxicity against P388 Murine Leukaemia Cells was through the interaction of apigenin with protein tyrosine kinase (c-Kit) with a stronger inhibitory activity than the control drug (Cytarabine) and had the same binding site as the control (Cytarabine).

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“…Based on the identification, several endophytic fungal isolates, including Daldinia eschscholtzii, have also been isolated from the genus Xestospongia sponge and are able to produce secondary metabolites (Sibero et al 2020). According to Sunariasih et al (2014), the fungus Sarocladium oryzae isolated from rice seeds has an inhibitory power against Pyricularia oryzae, the cause of blast disease in rice plants.…”

Section: Application Of Endophytic Fungal Isolate Combination In Plantsmentioning

confidence: 99%

Combination on endophytic fungal as the Plant Growth-Promoting Fungi (PGPF) on cucumber (Cucumis sativus)

et al. 2021

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Abstract. Syamsia S, Idhan A, Firmansyah AP, Noerfitryani N, Rahim I, Kesaulya H, Armus R. 2021. Combination on endophytic fungal as the Plant Growth-Promoting Fungi (PGPF) on Cucumber (Cucumis sativus). Biodiversitas 22: 1194-1202. Endophytic fungi are known to stimulate plant growth by producing secondary metabolites, including phytohormones (IAA and Gibberellins), siderophore, phosphate-solubilizing metabolites. In this study, a total of six endophytic fungi were successfully isolated from local rice plants and showed different abilities in producing secondary metabolites, during single isolates testing. These six isolates were then combined to obtain 15 combinations for analysis, to determine the best combination for application as a plant growth promoter. Subsequently, each combination was tested for phytohormones (IAA, gibberellins) and siderophore (quantitatively)-producing activity, phosphate-solubilizing ability, and the effect on cucumber (Cucumis sativus L) plant growth. F13 showed activity in producing IAA and produced the highest gibberellin levels, while F1 exhibited the highest phosphate-solubilizing activity. In addition, F11 (Na-salicylate) and F1 (catechol) showed the highest siderophore activity, while a combination of F6, F8, F9, and F12 successfully increased plant height growth. Also, F4 increased the root growth, while the fresh weight of cucumber was increased by F8 treatment, under controlled conditions. Molecular analysis showed the tested isolates have close similarity to Daldinia eschscholtzii, Sarocladium oryzae, Rhizoctonia oryzae, Penicillium allahabadense, and Aspergillus foetidus. The combination of endophyte fungal isolates showed potential as plant growth promoters, however, further testing on several plant types is required before the combination is to be widely applied.

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Chromanone-type compounds from marine sponge-derived Daldinia eschscholtzii KJMT FP 4.1

Cited by 7 publications

References 12 publications

Diversity of sponge-associated fungi from a mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia

Diversity of sponge-associated fungi from a mangrove forest in Kemujan Island, Karimunjawa National Park, Indonesia

Ethnomedicinal bioprospecting of Rhizophora apiculata leaves through in silico and in vitro approaches as antioxidant, ?-glucosidase inhibitor and anticancer

Combination on endophytic fungal as the Plant Growth-Promoting Fungi (PGPF) on cucumber (Cucumis sativus)

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