Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Benito-Arenas, Raúl; Zárate, Sandra G.; Revuelta, Julia; Bastida, Ágatha

doi:10.3390/catal9040322

Cited by 18 publications

(11 citation statements)

References 119 publications

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“…Unlike HSPGs, CSPG and DSPGs are a group of mostly secreted proteins forming an integral part of the ECM (Figure 1). They are involved in many essential physiological functions such as morphogenesis, inflammation and neuronal plasticity and play central roles in pathological processes such as cancer, osteoarthritis and thrombosis making them potential therapeutic targets (119,120). Several secreted matrix CS/DS and KS proteoglycans contain leucine-rich repeats (LRRs) in their protein core (around 42 kDa), categorizing them as small leucinerich proteoglycans (SLRPs).…”

Section: Chondroitin Dermatan and Keratan Sulfate Proteoglycans Have Pleotropic Roles In Meta-inflammation Initiation And Progressionmentioning

confidence: 99%

Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation

2020

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Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and meta-inflammation. Over the last decade, new insights have emerged on the mechanism and biological significance of these interactions in the context of diet-induced disorders such as obesity and type-2 diabetes. Complications of energy metabolism drive most diet-induced metabolic disorders, which results in low-grade chronic inflammation, thereby affecting proper function of many vital organs involved in energy homeostasis, such as the brain, liver, kidney, heart and adipose tissue. Here, we discuss how heparan, chondroitin and keratan sulfate proteoglycans modulate obesityinduced metabolic dysfunction and low-grade inflammation that impact the initiation and progression of obesity-associated morbidities.

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Section: Chondroitin Dermatan and Keratan Sulfate Proteoglycans Have Pleotropic Roles In Meta-inflammation Initiation And Progressionmentioning

confidence: 99%

Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation

2020

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“…To control biodegradability CS can be mixed with other polymers to make scaffolds. CS also has pharmacological applications such as coating material for implants and hydrogel in controlled drug release (Benito‐Arenas et al, 2019).…”

Section: Biomaterials From Marine Sourcementioning

confidence: 99%

Marine biological macromolecules as matrix material for biosensor fabrication

Bedi

Srivastava

et al. 2022

Biotech & Bioengineering

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The ocean covers two‐third of our planet and has great biological heterogeneity. Marine organisms like algae, vertebrates, invertebrates, and microbes are known to provide many natural products with biological activities as well as potential sources of biomaterials for therapeutic, biomedical, biosensors, and climate stabilization. Over the years, the field of biosensors has gained huge attention due to their extraordinary ability to provide early disease diagnosis, rapid detection of various molecules and substances along with long‐term monitoring. This review aims to focus on the properties and employment of various biomaterials (carbohydrate polymers, proteins, polyacids, etc.) of marine origins such as alginate, chitin, chitosan, fucoidan, carrageenan, chondroitin sulfate, hyaluronic acid, collagen, marine pigments, marine nanoparticles, hydroxyapatite, biosilica, lectins, and marine whole cell in the design and development of biosensors. Furthermore, this review also covers the source of such marine biomaterials and their promising evolution in the fabrication of biosensors that are potent to be employed in the biomedical, environmental science, and agricultural sciences domains. The use of such fabricated biosensors harnesses the system with excellent specificity, selectivity, biocompatibility, thermal stability, and minimal cost advantages.

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“…24 CS chains having a low and ultra-low M W , about 1500 to 2500 Da showed better antioxidant properties, resulting in more bioavailability via administering it orally, this has led to the development of bio-catalytic techniques using enzymes that degrade GAG, to procure chains that are size specific. 25 Sulfation patterns and specific sizes result in precise action, such as highly purified CS, having a size ranging from 15 to 16 kDa obtained from bovine tissues exhibited antiapoptotic and neuroprotective effects. 26 In contrast to HA, CS furthers cell adhesion, and thus can be utilized to develop non-adhesive polymers that show cell adhesion.…”

Section: Sources Of Extraction and Properties Of Csmentioning

confidence: 99%