Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

Abourehab, Mohammed A.S.; Baisakhiya, Shreya; Aggarwal, Akanksha; Singh, Anshul; Abdelgawad, Mohamed A.; Deepak, A.; Ansari, Mohammad Javed; Pramanik, Sheersha

doi:10.1039/d2tb01514e

Cited by 20 publications

(6 citation statements)

References 434 publications

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“…Two other downregulated pathways (glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulfate and mannose-type O-glycan biosynthesis) both involve protein modification. In the former pathway, chondroitin sulfate (CS), a natural anionic mucopolysaccharide, acts as the primary element of the extracellular matrix (ECM) of diverse organisms [47]; it also modifies collagen in the developing ovarian follicles of birds, forming chondroitin sulfate-modified collagen, also known as ggBM1 (Gallus gallus basement membrane protein 1). This protein is a major component between the vascularized follicular membrane and epithelioid granulosa cells [48]; it eventually forms type IV collagen networks as the follicles develop, which are important components of the eggshell membrane [49].…”

Section: Discussionmentioning

confidence: 99%

White Isthmus Transcriptome Analysis Reveals the Mechanism of Translucent Eggshell Formation

Ma,

Luo,

et al. 2024

Animals

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The presence of translucent eggshells is a type of egg quality issue that impacts egg sales. While many researchers have studied them, the exact mechanisms behind their formation remain unclear. In this study, we conducted a transcriptomic differential expression analysis of the isthmus region of the oviduct in both normal egg- and translucent egg-laying hens. The analysis revealed that differentially expressed gene pathways were predominantly concentrated in the synthesis, modification, and transport of eggshell membrane proteins, particularly collagen proteins, which provide structural support. These findings suggest that variations in the physical structure of the eggshell membrane, resulting from changes in its chemical composition, are the fundamental cause of translucent eggshell formation. This research provides a theoretical reference for reducing the occurrence of translucent eggs.

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Section: Discussionmentioning

confidence: 99%

White Isthmus Transcriptome Analysis Reveals the Mechanism of Translucent Eggshell Formation

Ma,

Luo,

et al. 2024

Animals

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“…Biopolymer-based scaffolds have garnered substantial attention within the domain of tissue engineering, principally attributed to their capability to develop a conducive environment that assists vital cellular functionalities and, consequently, the regeneration of tissues. [60][61][62] Laminarin, an underrated marinederived polysaccharide originating from brown algae, has acquired increasing attention in the domain of tissue engineering owing to its remarkable characteristics.…”

Section: Tissue Engineeringmentioning

confidence: 99%

From algae to advancements: laminarin in biomedicine

Pramanik,

Singh,

Abualsoud

et al. 2024

RSC Adv.

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“…Adequate porosity is essential as it offers ample space for growth of cell, ensuring that cells receive sufficient nutrients and facilitate the timely removal of metabolic waste [42,43]. Thus, porosity performs a vital role in the context of cell culture.…”

Section: Synthesis and Characterisation Insights Of Gelma Hydrogelsmentioning

confidence: 99%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the innate extracellular matrix (ECM) by integrating cell-adhering and matrix metalloproteinase-responsive peptide motifs. These features enable cellular proliferation and spreading within GelMA-based hydrogel scaffolds. Moreover, GelMA displays flexibility in processing, as it experiences crosslinking when exposed to light irradiation, supporting the development of hydrogels with adjustable mechanical characteristics. The drug delivery landscape has been reshaped by GelMA hydrogels, offering a favorable platform for the controlled and sustained release of therapeutic actives. The tunable physicochemical characteristics of GelMA enable precise modulation of the kinetics of drug release, ensuring optimal therapeutic effectiveness. In tissue engineering, GelMA hydrogels perform an essential role in the design of the scaffold, providing a biomimetic environment conducive to cell adhesion, proliferation, and differentiation. Incorporating GelMA in three-dimensional printing further improves its applicability in drug delivery and developing complicated tissue constructs with spatial precision. Wound healing applications showcase GelMA hydrogels as bioactive dressings, fostering a conducive microenvironment for tissue regeneration. The inherent biocompatibility and tunable mechanical characteristics of GelMA provide its efficiency in the closure of wounds and tissue repair.GelMA hydrogels stand at the forefront of biomedical innovation, offering a versatile platform for addressing diverse challenges in drug delivery, tissue engineering, and wound healing. This review provides a comprehensive overview, fostering an in-depth understanding of GelMA hydrogel’s potential impact on progressing biomedical sciences.

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Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

Abstract: Chondroitin sulfate (CS), a natural anionic mucopolysaccharide, belonging to the glycosaminoglycan family, acts as the primary element of the extracellular matrix (ECM) of diverse organisms. It comprises repeating units of...

Cited by 20 publications

References 434 publications

White Isthmus Transcriptome Analysis Reveals the Mechanism of Translucent Eggshell Formation

White Isthmus Transcriptome Analysis Reveals the Mechanism of Translucent Eggshell Formation

From algae to advancements: laminarin in biomedicine

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

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