Cholinesterase inhibitors from botanicals

Ahmed, Faiyaz; Ghalib, Raza Murad; Sasikala, P.; Ahmed, KK Mueen

doi:10.4103/0973-7847.120511

Cited by 92 publications

(60 citation statements)

References 56 publications

(38 reference statements)

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“…Some plants have traditionally been used for centuries to treat memory impairment. One of these species is Glaucium corniculatum, belonging to the family of Papaveraceae [10]. The species of the Papaveraceae biosynthesize pharmacologically active flavonoids, known to exhibit different pharmacological effects such as anti-inflammatory and neuroprotective [11].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Koçanci¹,

Aslım²

2017

International Journal of Secondary Metabolite

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Neurodegenerative diseases (NDs) are characterized by loss of neurons. NDs are associated with development of inflammation. Existing drugs against NDs only delay the progression; however, they do not provide a cure. The studies for the treatment of NDs focused on to discover natural products that have the potential of anti-inhibition and anti-radical properties. The Papaveraceae family members are important for the synthesis of pharmaceutically compounds such as flavonoids which act like anti-inflammatory drugs. In this study, methanol and water extracts of Glaucium corniculatum, a member of the Papaveraceae family, were analysed for flavonoid compounds. The effects of extracts on neuronal PC12 cells viability was determined. The anti-inflammatory effects of extracts were assessed by measuring the levels of IL-6 and IL-10 cytokines on hydrogen peroxide (H2O2)-stimulated PC12 cells. As a result of our studies, Rutin and Quercetin flavonoids have been found to be as major. The amount of Rutin was higher in methanol (45 μg/ml) than water (41 μg/ml). Quercetin was better extracted with methanol (12 μg/ml) than water (10 μg/ml). None of the tested extracts were cytotoxic even to PC12 cells. Both extracts showed an anti-inflammatory effect in a dose dependent manner. The water extract showed the maximum anti-inflammatory effect, with IL-6 secretion decreased 79 fold according to the H2O2 treated group and IL-10 secretion increased to 87 fold according to the control group. This study is an evidence that the Rutin and Quercetin flavonoids detected in G. corniculatum methanol and water extracts have a neuroprotective effect through anti-inflammation.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Koçanci¹,

Aslım²

2017

International Journal of Secondary Metabolite

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“…Indeed, many studies make out the effectiveness of alkaloids like a strong AChE inhibitors (Ahmed et al, 2013;Murraya et al, 2013). Moreover, many Alzheimer's drugs are made from plants alkaloids or their derivatives (Ng et al, 2015;Dall' Acqua, 2013).…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidant, antimicrobial and anti-acetylcholinesterase activities of organic extracts from aerial parts of three Tunisian plants and correlation with polyphenols and flavonoids contents

Sellem

Kaaniche

Chakchouk

et al. 2016

Bangladesh J Pharmacol

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In goal of searching new active compounds with important biological activities, a screening of several plants from salt-marsh region of Chebba-Tunisia had been realized. Three species had been selected: Calendula arvensis, Chenopodium murale and Nicotiana glauca. The organic extracts of different aerial parts of these plants (stems, leaves and flowers) displayed variable contents of total polyphenols (TPP) and total flavonoids (TF). Flowers acetone extract from N. glauca contained the higher quantity in TPP (264.8 ± 1.6 µg GA/mg), while stems dichloromethane extract exhibited the best TF content (49.8 ± 2.2 µg QE/mg). The important TPP and TF contents reflected a good anti-oxidant and antimicrobial activities. The best acetylcholinesterase inhibitory activity had been shown in the fractions obtained after extraction with low polarity solvents. Whence, a correlation of flavonoids contents with biological activities had been shown, while, there was no correlation with acetylcholinesterase inhibitory activity.

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“…Those enzymes are connected with the development of some neurodegenerative diseases. Reduced level of neurotransmitter acetylcholine is connected with the loss of memory that occurs in Alzheimer's disease (AD) so cholinesterase inhibitors are found to be effective in patients that suffer from mild to moderately level of AD (Ahmed et al, 2013). Tyrosinase is connected with Parkinson's disease (PD) as it is involved in the formation of neuromelanin which hyperproduction could be a trigger for PD (Greggio et al, 2005).…”

Section: Evaluation Of Antineurodegenerative Activitiesmentioning

confidence: 99%

Biological activities of Sorbus aucuparia L. leaves extract

et al. 2018

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Biological activities of Sorbus aucuparia L. leaves extract were tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was tested using four different assays (DPPH, ABTS, FRAP, and βcarotene test). In all antioxidant tests, concentration-dependent activity of leaves extract was noticed and the highest applied concentration (500 µg/ml) was the most active. Extract applied in a concentration of 200 µg/ml showed higher percent of DPPH inhibition compared with both concentrations of standard substances BHA and BHT (50 and 100 µg/ml). In the ABTS test, the activity of extract applied in 500 µg/ml was comparable or higher than BHA and BHT/Vitamin C, respectively. Moreover, all concentrations of tested extract were significantly more active in the β-carotene test than vitamin C. The lowest concentration of extract (100 µg/ml) was the most active in TYR assay reaching 42.57 % of the inhibition while in AChE assay there was not statistically significant differences among all applied concentrations.

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Cholinesterase inhibitors from botanicals

Cited by 92 publications

References 56 publications

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Anti-oxidant, antimicrobial and anti-acetylcholinesterase activities of organic extracts from aerial parts of three Tunisian plants and correlation with polyphenols and flavonoids contents

Biological activities of Sorbus aucuparia L. leaves extract

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