Biological activities of Sorbus aucuparia L. leaves extract

Abstract

Biological activities of Sorbus aucuparia L. leaves extract were tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was tested using four different assays (DPPH, ABTS, FRAP, and βcarotene test). In all antioxidant tests, concentration-dependent activity of leaves extract was noticed and the highest applied concentration (500 µg/ml) was the most active. Extract applied in a concentration of 200 µg/ml showed higher percent of DPPH inhibition compared with both concentrations of standard substances BHA and BHT (50 and 100 µg/ml). In the ABTS test, the activity of extract applied in 500 µg/ml was comparable or higher than BHA and BHT/Vitamin C, respectively. Moreover, all concentrations of tested extract were significantly more active in the β-carotene test than vitamin C. The lowest concentration of extract (100 µg/ml) was the most active in TYR assay reaching 42.57 % of the inhibition while in AChE assay there was not statistically significant differences among all applied concentrations.