Cholesterol vehicle in experimental atherosclerosis Part II. Peanut oil

Kritchevsky, David; Tepper, Shirley A.; Vesselinovitch, Dragoslava

doi:10.1016/0021-9150(71)90038-4

Cited by 136 publications

(38 citation statements)

References 9 publications

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“…This variation may reflect the generally stimulatory, more fibrogenic influence of the peanut oil component of the diet, and may be indirectly attributable to specific components of the peanut oil diet previously suggested to be the bases for its fibrogenic affect. 4 As noted, the lysyl oxidase activity was not markedly increased at 30 days, although serum cholesterol levels were highest at this time. However, increased aortic prolyl hydroxylase activity correlated well with cholesterol accumulated in aortic tissue.…”

mentioning

confidence: 62%

“…The control animals were maintained on rabbit chow, while the experimental animals were fed the same diet supplemented with cholesterol and peanut oil. The experimental diet consisted of 90 g of rabbit chow, 8 g of peanut oil, and 2 g of cholesterol per rabbit per day, similar to the diet regimen described by Kritchevsky et al 4 Animals were sacrificed in groups of five after 30, 60, 90, and 105 days by intravenous injections of sodium pentobarbital (Nembutal, 80 mg/kg). Aortas were quickly removed, cleaned of gross adventitial tissue, opened by longitudinal dissection, and graded according to the degree of atheroma.…”

Section: Animalsmentioning

confidence: 99%

“…18 In addition, the peanut oil-cholesterol diet induces a greater number and more severe lesions in the arch than in the abdominal aorta in this species. 4 Therefore, we wanted to assess the distribution of lysyl oxidase activity in the normal rabbit aortic wall. As shown in figure 1, lysyl oxidase activity was found throughout the aortic wall from the root to the iliac bifurcation, consistent with the presence of collagen and elastin in all aortic regions.…”

Section: Distribution Of Lysyl Oxidase In the Rabbit Aortamentioning

confidence: 99%

“…3 The accumulation of connective tissue proteins appears to be influenced by the specific nature of the atherogenic diet, since a diet containing 2% cholesterol further supplemented with 8% peanut oil induces lesions that are more fibrotic than a diet containing only high levels of cholesterol. 4 ' 5 Such alterations in the content and metabolism of collagen and elastin may be critical to the development and irreversibility of atherosclerotic lesions since these proteins can serve as lipid-binding sites. 67 Further, lipid complexes of elastin have increased susceptibility to elastolytic enzymes 8 and exhibit markedly decreased elasticity.…”

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confidence: 99%

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Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Kagan¹,

Raghavan²,

Hollander³

1981

Arteriosclerosis

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This study assessed the response of lysyl oxidase, the enzyme that initiates covalent crosslinking in elastin and collagen, by studying the aortic tissue of rabbits after arteriosclerosis had been induced by diet. Rabbits in the experimental group were fed an atherogenic diet of rabbit chow supplemented with 8% peanut oil and 2% cholesterol for varying periods of time, while the control group was fed only rabbit chow. Lysyl oxidase activity was found to be distributed throughout the length of the thoracic and abdominal aortas of the normal rabbits. However, rabbits fed the atherogenic diet showed marked increases in enzyme activity in the aortic arch, a change that was initially evident after 30 days and became greatest (2.5 times that of the controls) after 90 days. Enzyme activity in the study rabbits increased only minimally in the abdominal aortic wall. Aortic prolyl hydroxylase activity measured after 60 days of feeding changed in degree and manner similar to lysyl oxidase activity. These region-specific changes in enzyme activities correlated with the distribution and severity of aortic lesions in this model of the disease. Lysyl oxidase activity increased dramatically in this model of atherosclerosis, suggesting that this extracellular enzyme activity may prove to be a vulnerable and accessible point of control of the fibrotic response in atherosclerosis. (Arteriosclerosis 1981; 1:287-291)

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confidence: 62%

Section: Animalsmentioning

confidence: 99%

Section: Distribution Of Lysyl Oxidase In the Rabbit Aortamentioning

confidence: 99%

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confidence: 99%

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Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Kagan¹,

Raghavan²,

Hollander³

1981

Arteriosclerosis

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“…24 The atherogenic effects of coconut oil, peanut oil, corn oil, and combined safflower, cottonseed, and olive oil was compared in rabbits fed a 2% cholesterol-enriched diet. 8 Com oil and the combined oil with 55% olive oil had a similar, but lower, atherogenic index than did coconut oil and peanut oil. In another study with rabbits fed a cholesterol-free, semipurified diet, olive oil was found less atherogenic than peanut oil.…”

Section: Downloaded Frommentioning

confidence: 84%

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

et al. 1988

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Two groups of 18 rabbits were fed Isocalorlc, cholesterol-enriched diets for 8 weeks. The diet for one group was supplemented with 5% corn oil. The concentration of cholesterol in plasma was determined weekly and the amount of cholesterol In the diet was adjusted Individually so that each rabbit had a mean plasma cholesterol concentration of about 45 mM during the experimental period. The aortic cholesterol concentrations were 122 ± 29 and 193 ± 38 (mean ± SEM) /xmol/g protein for the cornoil group and the control group, respectively (p<0.05). In a similar experiment, each of 36 rabbits was given a mean plasma cholesterol level of about 20 mM over a period of 12 weeks. One-third of the rabbits received 10% to 15% corn oil, another third 10% to 15% olive oil, while the last third served as a control group. The aortic cholesterol concentrations were 98 ± 25, 57 ± 9, and 131 ± 32 ^mol/g protein, respectively. The value for the olive-oil group was significantly (p<0.01) lower than the value for the control group. The trlglycerlde concentrations and the distributions of cholesterol between HDL, LDL, and VLDL In plasma showed no significant differences between the plant-oil groups and their control groups. This suggests that plant oils have a direct effect on the aortic cholesterol metabolism. (Arteriosclerosis 8:281-287, May/June 1988)

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A Possible Protective Effect of Nut Consumption on Risk of Coronary Heart Disease

Fraser¹

1992

Arch Intern Med

489

127

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Cholesterol vehicle in experimental atherosclerosis Part II. Peanut oil

Cited by 136 publications

References 9 publications

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

A Possible Protective Effect of Nut Consumption on Risk of Coronary Heart Disease

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