Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

Leth-Espensen, Per; Stender, Steen; Ravn, Hans; Kjeldsen, Knud

doi:10.1161/01.atv.8.3.281

Cited by 38 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our study, others found that addition to the diet of cholesterol in an evaporable solvent without the use of additional fat resulted in a more atherogenic hypercholesterolemia than that produced when oils were used for the addition of cholesterol, although the plasma cholesterol level was higher in the group that received the additional fat. 53 Hypertriglyceridemia is accompanied by larger lipoprotein particles that reduce the influx of lipoprotein into the arterial wall, 54 and in study A of the present investigation, there was a more rapid rise in triacylglycerol concentration compared with that in study B (Table 1). We have previously suggested that this might explain why even small diet modifications influence the impairment of endothelial function in small arteries.…”

Section: Evidence For Diet-dependent Effect Of Endothelium-mediated Rmentioning

confidence: 43%

“…Furthermore, others found that the distribution of cholesterol between the plasma lipoproteins in the cholesterol-fed rabbits fed additional fat was similar to the rabbits fed a diet where cholesterol was added by use of ether. 53 Although speculative, the use of the vehicles in the present studies may have affected the levels of lipid peroxides present in the hypercholesterolemic rabbits, which have been reported to reduce PG and EDRF release in large arteries.…”

Section: Evidence For Diet-dependent Effect Of Endothelium-mediated Rmentioning

confidence: 85%

See 1 more Smart Citation

Effect of induced hypercholesterolemia in rabbits on functional responses of isolated large proximal and small distal coronary arteries.

Simonsen

Prieto

Mulvany

et al. 1992

Arterioscler Thromb

View full text Add to dashboard Cite

We studied the effects of hypercholesterolemia on the vascular responses of proximal and distal parts of the rabbit coronary circulation in two consecutive studies. For 12 weeks, New Zealand White rabbits were fed a control diet or a diet with 1% cholesterol dissolved in either 3% coconut oil (study A) or ether (study B). Isolated proximal epicardial and distal intramyocardial coronary arteries from control and hypercholesterolemic rabbits were mounted for isometric tension recording in a double myograph. In study A for hypercholesterolemic rabbits (A=12), the maximal relaxation and sensitivity to acetylcholine (ACh) were significantly decreased in proximal coronary segments contracted with 30 mmol/1 potassium solution compared with segments from control rabbits (it=13). The only change observed in distal coronary segments was a slight decrease in relaxation in response to low ACh concentrations (10~* and 3 x 10~* mol/1). However, in study B for proximal coronary and distal coronary segments from hypercholesterolemic rabbits (n=13), the area under the ACh relaxation curve was increased compared with that of control r abbits (n = 12). Other parameters that were similarly affected in studies A and B include the following: 1) proximal coronary segments from hypercholesterolemic rabbits were more sensitive to sodium nitroprusside (SNP) than were those from control rabbits, but this was not true for distal coronary segments; 2) endothelial removal from arterial segments of control rabbits induced a significant increase in sensitivity and maximal relaxation to SNP of proximal coronary and distal coronary arteries; 3) in segments from hypercholesterolemic rabbits, the absence of endothelium did not alter the response of proximal coronary segments to SNP but did augment the relaxation of distal coronary segments to SNP; 4) the maximal response to 5-hydroxvtrvptamine in proximal coronary arteries from hypercholesterolemic rabbits was increased compared with those from control rabbits, whereas such changes were not observed in distal coronary arteries; and 5) histological examination showed the presence of atheromatous plaques in proximal coronary but not in distal coronary segments from treated animals. In conclusion, the present investigation demonstrates that induced hypercholesterolemia alters both the structure and function of proximal parts of the coronary circulation. In distal coronary arteries of hypercholesterolemic rabbits, the only change observed was an impaired endothelium-dependent cholinergie relaxation, but even this change appeared to be dependent on the manner in which cholesterol was added to the diet, although parallel studies are required to confirm this. (

show abstract

Section: Evidence For Diet-dependent Effect Of Endothelium-mediated Rmentioning

confidence: 43%

Section: Evidence For Diet-dependent Effect Of Endothelium-mediated Rmentioning

confidence: 85%

Effect of induced hypercholesterolemia in rabbits on functional responses of isolated large proximal and small distal coronary arteries.

Simonsen

Prieto

Mulvany

et al. 1992

Arterioscler Thromb

View full text Add to dashboard Cite

show abstract

“…In contrast, a previous study suggests that the TPC concentration in rabbits fed polyunsaturated fat would be lower than those fed monounsaturated fat if similar cholesterol supplements were used (90). Two other studies have reported that the TPC concentration of monounsaturated fat-fed rabbits was intermediate between saturated fat-fed and polyunsaturated fat-fed rabbits (92,93).…”

Section: Discussionmentioning

confidence: 88%

“…Other studies of cholesterol-induced atherosclerosis in rabbits have reported a correlation between the accumulation of arterial cholesterol and the TPC concentration. However, polyunsaturated fat-fed animals had less atherosclerosis in one study, and monounsaturated fat-fed animals less in the other (90,92). The reason for these differences are not clear, but Kritchevsky has suggested that cholesterol-induced atherosclerosis in rabbits was sensitive to the ratio of dietary monounsaturated to saturated fats (29).…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Schwenke

Rudel

Sorci‐Thomas

et al. 2002

Journal of Lipid Research

View full text Add to dashboard Cite

In this study, we asked the question "does ␣ -tocopherol supplementation prevent an increase in total plasma cholesterol (TPC) concentration and reduce the deposition of cholesterol in arterial plaques of rabbits fed atherogenic diets?" Isocaloric diets containing 0.1% cholesterol to induce atherosclerosis were enriched in one of three fats: saturated fats (SAT), monounsaturated fats (MONO), or n-6 polyunsaturated fats (POLY). Half of each of the three diets were supplemented with 2,500 IU ␣ -tocopherol/kg-diet. Unsupplemented diets contained 25 IU ␣ -tocopherol/kg-diet. Rabbits supplemented with ␣ -tocopherol had plasma ␣ -tocopherol concentrations 10-fold higher and an average TPC concentration 31% lower, P ‫؍‬ 0.017, than rabbits fed unsupplemented diets. Among the three fat-fed groups, the difference was greatest for the POLY fat fed group (54%, P ‫؍‬ 0.041). POLY fat-fed rabbits without ␣ -tocopherol supplementation had plasma HDL cholesterol concentrations that were less than half that of rabbits fed other fats, P р 0.0001. In general, differences in mean esterified artery cholesterol concentrations among the three fat-fed groups, with and without ␣ -tocopherol supplementation, paralleled differences in TPC concentration among the groups.This study suggests that for rabbits fed high pharmacological doses of ␣ -tocopherol, atherosclerosis can be diminished in situations where the plasma cholesterol concentrations are also significantly lower. -Schwenke, D. C., L. L. Rudel, M. G. Sorci-Thomas, and M. J. Thomas. ␣ -Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits.

show abstract

Influence of lovastatin on the pharmacokinetics, toxicity and immunologic response of cyclosporine in the obese zucker rat

Berens

Vadiei

Brunner

et al. 1990

Biopharm & Drug Disp

View full text Add to dashboard Cite

The combined use of lovastatin, a hypolipidemic agent effective in the reduction of cholesterol levels, and the lipophilic immunosuppressant, cyclosporine, was studied in the obese rat model. Pharmacokinetics, immunosuppressive activity, lipid levels, and creatinine clearances were compared between groups administered drug-free vehicle, lovastatin or cyclosporine alone, or concomitant cyclosporine and lovastatin. All groups were pre-treated with either oral lovastatin 2.5 mg kg-1 day-1 or propylene glycol vehicle for 1 week. Although no differences in renal function were observed in rat groups administered cyclosporine or lovastatin alone, there was a significant reduction in baseline creatinine clearance following combination therapy compared to placebo controls (70 +/- 18 vs 121 +/- 16 per cent of baseline; p less than 0.05). No differences in trough cyclosporine concentrations were observed between groups. Similarly, mean areas under the whole blood concentration-time profiles were not significantly different with or without concomitant lovastatin (61823 +/- 27295 vs 41470 +/- 10312 ng h ml-1; p = 0.13). No differences in systemic clearance or volume of distribution of parent cyclosporine were observed with combination therapy. Furthermore, lipid levels and T-lymphocyte activity were unchanged with the addition of lovastatin. Per cent increases in creatine kinase were significantly correlated with percentage drop in baseline renal function, suggesting the development of rhabdomyolysis. The present data support the interaction between cyclosporine and lovastatin observed clinically, resulting in acute renal dysfunction. Caution should be exercised in their combined use.

show abstract

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

Cited by 38 publications

References 29 publications

Effect of induced hypercholesterolemia in rabbits on functional responses of isolated large proximal and small distal coronary arteries.

Effect of induced hypercholesterolemia in rabbits on functional responses of isolated large proximal and small distal coronary arteries.

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Influence of lovastatin on the pharmacokinetics, toxicity and immunologic response of cyclosporine in the obese zucker rat

Contact Info

Product

Resources

About