Chitosan–hydroxycinnamic acid conjugates: Preparation, antioxidant and antimicrobial activity

Lee, Daesung; Woo, Ji-Young; Ahn, Chang‐Bum; Je, Jae‐Young

doi:10.1016/j.foodchem.2013.10.019

Cited by 154 publications

(104 citation statements)

References 21 publications

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“…The results of antibacterial effect of chitosan-phytochemical conjugates against acne-related bacteria were accordance with the previous reports that the chitosan-phytochemical conjugates exhibited higher antimicrobial activity than that of unmodified chitosan [12,18]. The MICs of chitosan-phytochemical conjugates were in the range of 32 μg/mL to 512 μg/mL against foodborne pathogens, while the MICs of the unmodified chitosan were in the range of 128 μg/mL to 1,024 μg/mL.…”

Section: Discussionsupporting

confidence: 90%

“…Hydroxycinnamic acids (HAs) including caffeic acid, ferulic acid, and sinapic acid are naturally occurring phytochemicals from plants and have been used in pharmaceutical, cosmetics, and food industry [18,19,20]. In this study, chitosan-phytochemical conjugates were synthesized by conjugating HAs into the chitosan backbone according to the previous method [12,18].…”

Section: Antibacterial Effect Of Chitosan-phytochemical Conjugates Agmentioning

confidence: 99%

“…In this study, chitosan-phytochemical conjugates were synthesized by conjugating HAs into the chitosan backbone according to the previous method [12,18]. It was then assessed an antibacterial activity of chitosan-phytochemical conjugates against acne-related bacteria.…”

Section: Antibacterial Effect Of Chitosan-phytochemical Conjugates Agmentioning

confidence: 99%

“…However, as described above, most studies related chitosan and its derivatives have been focused on the biological activities such as antioxidant, antitumor, and anti-inflammatory effect, not antimicrobial activity [15][16][17]. It has been previously reported that chitosan derivatives conjugated with phytochemicals (caffeic acid, ferulic acid, and sinapic acid), which exhibited strong antibacterial activity against pathogenic bacteria [12,18]. However, no further experiment was progressed against other pathogenic bacteria, especially acne-related bacteria.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic Resistant Acne-Related Bacteria

Kim

Eom

et al. 2017

Preprint

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Abstract:The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, which is one of the most common skin diseases. Acne vulgaris often associates with acne-related bacteria such as Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, some of which exhibit a resistant against commercial antibiotics used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). In the current study, we evaluated in vitro antibacterial activity of chitosanphytochemical conjugates against acne-related bacteria. Three of chitosan-phytochemical conjugates used in this study showed stronger antibacterial activity than that of chitosan (unmodified control). Chitosan-caffeic acid conjugate (CCA) exhibited the highest antibacterial activity against acne-related bacteria with minimum inhibitory concentration values of 8 μg/mL to 256 μg/mL. In addition, the MICs of antibiotics against antibiotic resistant P. acnes and P. aeruginosa strains were dramatically reduced in the combination with CCA, suggesting that CCA would restore the antibacterial activity of the antibiotics. The analysis of fractional inhibitory concentration indices clearly revealed a synergistic antibacterial effect between CCA and the antibiotics. Thus, the median ∑FIC values against the antibiotic resistant bacterial strains were ranged from 0.375 to 0.533 in the combination mode of CCA and antibiotics.

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Section: Discussionsupporting

confidence: 90%

Section: Antibacterial Effect Of Chitosan-phytochemical Conjugates Agmentioning

confidence: 99%

Section: Antibacterial Effect Of Chitosan-phytochemical Conjugates Agmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic Resistant Acne-Related Bacteria

Kim

Eom

et al. 2017

Preprint

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“…Table 3 shows the results obtained through the docking study between compounds 1-6 with the enzyme glyceraldehyde 3-phosphate dehydrogenase [33]. …”

Section: Molecular Descriptorsmentioning

confidence: 99%

Computational study of aromatic compounds inhibiting<em> Trypanosoma cruzi</em> glyceraldehyde 3-phosphate dehydrogenase

Delmondes

Moraes

Stefani

2017

Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd Edition

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Chagas disease is caused by the protozoan Trypanosoma cruzi and is widely distributed throughout Latin America. Because it is a pathology neglected by the pharmaceutical industry and because existing drugs have low efficacy and several side effects, interest in new drugs has been increasing. Due to the necessity of the discovery of new structures, the objective of this work was to relate the biological activity of natural and semi-synthetic aromatic compounds, inhibitors of glyceraldehyde 3-phosphate dehydrogenase enzyme, with descriptors calculated by molecular modeling, such as HOMO-LUMO frontier orbitals, partition coefficient (LogP) and water solubility (LogS), in addition to performing a molecular docking study, in order to obtain a better molecular view of the interaction of the aromatic compounds with the active site of the enzyme. It was observed that the compounds involved in the study interacted attractively with the enzyme, in accordance with experimental studies, and had adequate solubility for good pharmacokinetics. It was also possible to relate the pharmacological activity of some compounds with the energy of the LUMO orbital. The study showed that the methodology used in this work can be used to understand the interaction of active compounds with their respective targets, saving time and resources. __________________________________________________________________________________ Keywords: Chagas disease, molecular docking, molecular modeling, aromatic compounds Graphical Abstract:MOL2NET, 2017, 3, http://sciforum.net/conference/mol2net-03 2 Introduction:

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Chitosan–Antioxidant Conjugates

Nagy

Másson

2020

Encyclopedia of Marine Biotechnology

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Chitosan–hydroxycinnamic acid conjugates: Preparation, antioxidant and antimicrobial activity

Cited by 154 publications

References 21 publications

Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic Resistant Acne-Related Bacteria

Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic Resistant Acne-Related Bacteria

Computational study of aromatic compounds inhibiting<em> Trypanosoma cruzi</em> glyceraldehyde 3-phosphate dehydrogenase

Chitosan–Antioxidant Conjugates

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