A busca por novas áreas da Farmácia tem levado muitos profissionais a se especializarem na área da estética. Essa mudança de nicho tem relação com a crescente busca da sociedade por procedimentos estéticos. Nesse sentido o presente estudo busca descobrir o perfil do farmacêutico que encontrou na área da estética um novo ramo de atuação bem como avaliar o grau de satisfação deles diante do mercado. Trata-se de um estudo analítico observacional de corte transversal que busca identificar fatores que contribuem para a inserção e satisfação do farmacêutico esteta no mercado de trabalho. Os resultados mostraram que o farmacêutico esteta é, predominantemente, um profissional formado em faculdade privada, com experiência de 6 a 10 anos no mercado de trabalho que posteriormente buscou a especialização na área de estética, atua há pouco tempo no nicho, trabalha em tempo integral e em consultórios próprios. Por fim, e mais importante, a maioria está satisfeita com a área de atuação. Desta forma, a presença do farmacêutico na estética acrescenta mais uma opoetunidade de atuação ao profissional bem como apresenta o vantagem de ser um profissional que vai entender melhor a farmacocinética e farmacodinâmica dos ativos utilizados nas técnicas da estética.
Objetivo: Caracterizar o perfil epidemiológico dos pacientes portadores de tuberculose nos municípios de Barra do Garças e Campinápolis, Mato Grosso. Métodos: Trata-se de um estudo epidemiológico descritivo, observacional, de corte transversal, com dados secundários derivados do Sistema de Informação de Agravos de Notificação (SINAN) e do Instituto Brasileiro de Geografia e Estatística (IBGE). Resultados: Observou-se que em Barra do Garças o maior número de pessoas notificadas com tuberculose foi no ano de 2018, com idade entre 40 e 49 anos, predominantemente na raça/cor branca, com a maioria dos casos confirmados laboratorialmente e evoluídos para a cura. Em Campinápolis ocorreu maior número de casos no ano 2015, a maioria com idade entre 10 e 14 anos, predominantemente na raça/cor indígena, com a maioria dos casos sem confirmação laboratorial e evoluídos para a cura. Conclusão: Portanto, o perfil dos casos de tuberculose nos dois municípios reflete a realidade de cada um deles.
Natural phenolic acids such as gallic, caffeic, ferulic and sinapic acids, have received great attention due to their biological activities, like antioxidant, anti-inflammatory and others. These properties put them as good candidates for the new controlled drug release systems. Among the various types of polymeric materials used in the development of controlled release systems for active drugs and films, chitosan is highlighted because it has many favorable characteristics, such as biocompatibility and biodegradability. To verify the behavior of such phenolic acids in hydrophilic biological fluids and hydrophobic biological barriers aimed at the production of new systems of modified drug release, in the present work it was conducted in silico simulation of solubility in water and in 1-octanol by molecular dynamics. The interaction of these phenolic compounds with chitosan was also investigated by molecular docking. The results showed that all investigated phenolic acids showed adequate solubility and good interaction with chitosan. The results show that the methodology applied in the present work can be well used for the development of pharmacologically active compounds and can aid the understanding of the interaction of such compounds with polymers, saving time and resources.
Today, the cosmetics segment has become one of the most successful areas in the world. Among the most varied types of cosmetics on the market, hydrogels are highlighted because they have characteristics similar to the biological fluids. Hydrogels are structures with threedimensional polymer chains that can act as carriers of active principles, including substances with antioxidant activity, that can be used to prevent premature aging of the skin. Recent research has shown good results for hydrogels formed with chitosan, which is a naturally occurring, nontoxic and biodegradable polymer. Thus, the objective of this study was to perform the interaction of the phenolic compounds vitamin E (tocopherol), gallic acid, ferulic acid, artemetin and quercetin, which possess antioxidant activity, with the chitosan, aiming at hydrogel planning with antioxidant activity. The study was performed by molecular docking. The phenolic compounds were obtained by PUBCHEM, while chitosan was obtained through the PolySac3DB.For molecular docking, polar hydrogen and gasteiger charges were added to the chitosan molecule and to the ligands. The method used was the genetic algorithm Lamarckian in 100 runs. All compounds interacted with chitosan attractively but quercetin was the most stable interacting compound with energy expenditure at -3.92 kcal / mol, whereas gallic acid, ferulic acid, caffeic acid , vitamin E (tocopherol) and artemetin had energy expenditure at -2.25 kcal / mol, -2.12 kcal / mol, -2.59 kcal / mol, -2.44 kcal / mol and -2.73 kcal / mol, respectively. The study showed that both compounds have molecular conditions for interacting with chitosanbased hydrogels, but for faster releases, compounds with less stable interactions (higher energy) can be used, while for longer releases, quercetin may be used, since its interaction stability is greater.
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