Chitosan–Antioxidant Conjugates

Nagy, Vivien; Másson, Már

doi:10.1002/9781119143802.ch40

Cited by 2 publications

(1 citation statement)

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“…The available literature describes different CS modifications by catechol [54], quaternary ammonium groups [55], or Schiff bases [56]. Various synthetic approaches are available for obtaining CS derivatives, such as direct modification, enzymatic reactions, or chemical grafting [57]. It should be noted that executing a successful multistep organic synthesis of complex molecules can be a challenging process.…”

Section: Analysis Of Antibacterial and Antifungal Activity Of Cip-chi...mentioning

confidence: 99%

Synthesis and Characterization of Antibacterial Chitosan Films with Ciprofloxacin in Acidic Conditions

Sikorski,

Rosiak,

Janczewski

et al. 2023

IJMS

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This work presents the results of research on obtaining chitosan (CS) films containing on their surface ciprofloxacin (CIP). A unique structure was obtained that not only gives new properties to the films, but also changes the way of coverage and structure of the surface. The spectroscopic test showed that in the process of application of CIP on the surface of CS film, CIP was converted from its crystalline form to an amorphic one, hence improving its bioavailability. This improved its scope of microbiological effect. The research was carried out on the reduction of CIP concentration during the process of CIP adhesion to the surface of chitosan films. The antibacterial activity of the CS films with and without the drug was evaluated in relation to Escherichia coli and Staphylococcus aureus, as well as Candida albicans and Penicillium expansum. Changes in the morphology and roughness of membrane surfaces after the antibacterial molecule adhesion process were tested with atomic force microscopy (AFM) and scanning electron microscopy (SEM). Structural analysis of CS and its modifications were confirmed with Fourier-transform spectroscopy in the infrared by an attenuated total reflectance of IR radiation (FTIR-ATR) and solid-state nuclear magnetic resonance (NMR).

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