Chitosan effects on glass matrices evaluated by biomaterial. MAS-NMR and biological investigations

Oudadesse, Hassane; Wers, Éric; Bui, Xuan Vuong; Roiland, Claire; Bureau, Bruno; I, Akhiyat; Mostafa, Amany A.; Chaair, Hassan; Benhayoune, Hicham; Fauré, J.; Pellen‐Mussi, Pascal

doi:10.1007/s11814-013-0104-x

Cited by 19 publications

(18 citation statements)

References 26 publications

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“…The deposition of calcium phosphate allows 46S6-CH to form a chemical bond with the bone tissue. Rapid dissolution of the glassy network in 46S6-CH composite in comparison to 46S6 glass has been observed during in vitro experiments [93].…”

Section: Bioceramic/polymer Composites For Bone Reconstructionmentioning

confidence: 90%

“…Bioactive glasses have been used as implant materials in the human body to repair and replace diseased or damaged bone. The formation of apatite layer promotes the adhesion of bone tissues to the implant and enhances bone repair or reconstruction [93]. When compared with synthetic hydroxyapatite, bioactive glasses offer superior properties such as gene activation, high level of bioactivity, and a better bone regenerative capability [94].…”

Section: Chemical Compositionmentioning

confidence: 99%

“…Oudadesse et al [93] and Wers et al [122] have investigated the in vitro characteristics of 46S6 and Cu-Zn-doped 46S6 bioactive glasses by soaking the glass powders into the simulated body fluid (SBF) with pH and mineral composition similar to that of human blood plasma. The SBF solution was prepared by dissolving NaCl, NaHCO 3 , KCl, K 2 HPO 4 ·3H 2 O, MgCl 2 ·6H 2 O, and CaCl 2 in deionized water and buffering with (CH 2 OH) 3 CNH 2 and HCl 6N to obtain a pH value of 7.4 according to Kokubo's technique [140,141].…”

Section: Biological Propertiesmentioning

confidence: 99%

“…The XRD results after soaking in SBF showed two characteristic peaks of HA at 26° and 32°, where the intensity increased with time and became more pronounced after 30 days. Fourier transform infrared spectroscopy (FTIR) was also used to detect the appearance of HA by the bands at 563 and 606 cm -1 [93]. The SEM micrographs taken from the surface of 46S6 showed the presence of a homogeneous and well-crystallized hydroxyapatite (HA) layer after 30 days ( Figure 17A) [122].…”

Section: Biological Propertiesmentioning

confidence: 99%

“…Composites of chitosan and bioactive glasses can be prepared by a wide range of fabrication techniques. Figure 18A shows a typical process for the synthesis of chitosan/ bioactive glass composites [93,139]. First, a solution of chitosan (CH) in acetic acid is prepared (1 wt%), stirred, and filtered to obtain a homogeneous viscous polymer solution.…”

Section: Bioceramic/polymer Composites For Bone Reconstructionmentioning

confidence: 99%

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Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

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Section: Bioceramic/polymer Composites For Bone Reconstructionmentioning

confidence: 90%

Section: Chemical Compositionmentioning

confidence: 99%

Section: Biological Propertiesmentioning

confidence: 99%

Section: Biological Propertiesmentioning

confidence: 99%

Section: Bioceramic/polymer Composites For Bone Reconstructionmentioning

confidence: 99%

See 3 more Smart Citations

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Effect of novel curcumin‐encapsulated chitosan–bioglass drug on bone and skin repair after gamma radiation: experimental study on a Wistar rat model

Jebahi

Saoudi

Farhat

et al. 2015

Cell Biochemistry & Function

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Radiation therapy contributes to a significant increase in bone osteoporosis and skin loss. Various natural health products might be beneficial to reduce bone and skin alterations. Curcumin (CUR) medicines derived from natural plants have played an important role in health care. This study aims at synthesizing and evaluating the performance therapy of CUR-encapsulated bioglass-chitosan (CUR-BG-CH). In vitro, the antioxidant assay was evaluated by using 1,1-diphenyl-2-picrylhydrazyl free-radical (DPPH) scavenging and the nitroblue tetrazolium reduction. The CUR-BG-CH antimicrobial effects were tested in liquid media. In vivo, after rat (60) Co γ-radiation, the tissue wound-healing process was studied by grafting CUR and CUR-BG-CH in femoral condyle and dorsal skin rat tissue. The antioxidant studies indicated that CUR-BG-CH quenches free radicals more efficiently than unmodified CUR and had effective DPPH (91%) and superoxide anion (51%) radical scavenging activities. The CUR-BG-CH biomaterial exhibited an important antimicrobial activity against Staphylococcus aureus. The histomorphometric parameters showed amelioration in CUR-BG-CH-treated rats. An improved mechanical property was noticed (33.16 ± 5.0 HV) when compared with that of unmodified CUR group (23.15 ± 4.9 HV). A significant decrease in tumour necrosis factor-α cytokine production was noted in the CUR-BG-CH rats (90 pg/ml) as compared with that of unmodified CUR group (240 pg/ml). The total amount of hydroxyproline was significantly enhanced (33.5%) in CUR-BG-CH group as compared with that of control. Our findings suggested that CUR-BG-CH might have promising potential applications for wound healing.

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Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications

Oudadesse

Najem

Mosbahi

et al. 2020

J Biomedical Materials Res

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Bone tissue engineering is gaining popularity as an alternative method for the treatment of osseous defects. A number of biodegradable polymers have been explored for tissue engineering purposes. A new family of biodegradable polymer/bioactive glass composite materials has been designed to be used in bone regeneration approaches. In this work, a hybrid scaffold of chitosan (CH) and bioactive glass nanoparticles (BGN) was prepared by the freeze‐gelation method. This method has been studied by adjusting the concentration of acetic acid; this process can influence the structure properties of the scaffold. In this work, several BGN/CH composites have been prepared by varying the proportion of BGN in the hybrid scaffold (20, 40, 60, and 80%). Brunauer–Emmett–Teller results showed the increased surface area and porosity volume of our composite with decreasing BGN proportion. BGN/CH hybrid scaffold was characterized by using physicochemical techniques. Obtained results showed a macroporous morphology of the scaffold with a pore size of about 200 μm, and a homogeneous distribution of the BGN in the CH matrix. X‐ray diffraction study confirmed the amorphous state of the BGN/CH hybrid scaffold. Interaction between CH and BGNs in the composite was confirmed. The in vitro assays showed adequate degradation properties, which is essential for the potential replacement by the new tissue. The in vitro bioactivity studies confirmed the formation of an apatite layer on the surface of the hybrid scaffold, which results in a direct bone bonding of the implant. These results indicate that BGN/CH hybrid scaffold developed is a potential candidate for bone tissue engineering.

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Chitosan effects on glass matrices evaluated by biomaterial. MAS-NMR and biological investigations

Cited by 19 publications

References 26 publications

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Effect of novel curcumin‐encapsulated chitosan–bioglass drug on bone and skin repair after gamma radiation: experimental study on a Wistar rat model

Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications

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