Chitosan-based polymer hybrids for thermo-responsive nanogel delivery of curcumin

Luckanagul, Jittima Amie; Pitakchatwong, Chutamart; Bhuket, Pahweenvaj Ratnatilaka Na; Muangnoi, Chawanphat; Chirachanchai, Suwabun; Wang, Qian; Rojsitthisak, Pornchai

doi:10.1016/j.carbpol.2017.11.027

Cited by 129 publications

(70 citation statements)

References 45 publications

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“…On the other hand, at pH 5.4, the release rates are a little higher than that of pH 7.4 and all loaded Imatinib molecules release within 120 min. It means that the drug release rate of Fe 3 O 4 @CS/Imatinib is pH dependent and lower pH levels lead to faster release of Imatinib from this nanocomposite. It should be noted that, compared with the release behavior of the other Fe 3 O 4 @CS/drug nanocomposites, the Fe 3 O 4 @CS/Imatinib NPs do not involve any burst phenomenon at the beginning of the release trials.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Ghezeli

Hekmati

Veisi

2019

Applied Organom Chemis

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Targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy. In this respect, Imatinib‐loaded chitosan‐modified magnetic nanoparticles were prepared as a pH sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field. The proposed magnetic nanoparticles were prepared through modification of magnetic Fe3O4 nanoparticles with chitosan and Imatinib. The structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy‐dispersive X‐ray spectroscopy (EDS), field emission scanning electron microscopy (FESEM), Fourier‐transform infrared (FTIR) spectroscopy, high resolution transmission electron microscopy (HR‐TEM), vibrating sample magnetometry (VSM), X‐ray diffraction (XRD) and X‐ray photoelectron spectroscopy (XPS). UV/visible spectrophotometry was used to measure the Imatinib contents. Thermal stability of the prepared particles was investigated and their efficiency of drug loading and release profile were evaluated. The results demonstrated that Fe3O4@CS acts as a pH responsive nanocarrier in releasing the loaded Imatinib molecules. Furthermore, the Fe3O4@CS/Imatinib nanoparticles displayed cytotoxic effect against MCF‐7 breast cancer cells. Results of this study can provide new insights in the development of pH responsive targeted drug delivery systems to overcome the side effects of conventional chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Ghezeli

Hekmati

Veisi

2019

Applied Organom Chemis

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“…All these advantageous characteristics make stimulus-responsive hydrogels an optimal option for the robust loading of therapeutic drugs and the subsequent controllable release of those drugs when and where they are needed through precise modulation of the surrounding environment (e.g., pH, temperature, and light) or the application of external physical fields (e.g., magnetic and electric fields) 97,[129][130][131][132] . The corresponding applications of drug-delivery systems based on stimulus-responsive hydrogels include neural disease treatment, cancer chemotherapy, and wound healing [133][134][135][136] .…”

Section: Drug Deliverymentioning

confidence: 99%

“…Having a volume-/phase-transition temperature (LCST of 32°C) close to the human physiological temperature (37°C), the drug release from the PNIPAAm-based system can be spontaneously activated as soon as the drug enters the human body. This drug-unloading mechanism brings about unparalleled easy accessibility without any further applied stimuli; thus, PNIPAAm has been highlighted as an appealing candidate in bioactuator design and fabrication for thermally induced drug release 56,133,[136][137][138] . The PNIPAAm hydrogel has been shown to efficiently release drugs (e.g., doxorubicin and lysozyme 56 ) under heating, which can be explained by the collapse of chains and the shrinkage of the hydrogel network.…”

Section: Drug Deliverymentioning

confidence: 99%

Bioactuators based on stimulus-responsive hydrogels and their emerging biomedical applications

et al. 2019

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The increasingly intimate bond connecting soft actuation devices and emerging biomedical applications is triggering the development of novel materials with superb biocompatibility and a sensitive actuation capability that can reliably function as bio-use-oriented actuators in a human-friendly manner. Stimulus-responsive hydrogels are biocompatible with human tissues/organs, have sufficient water content, are similar to extracellular matrices in structure and chemophysical properties, and are responsive to external environmental stimuli, and these materials have recently attracted massive research interest for fabricating bioactuators. The great potential of employing such hydrogels that respond to various stimuli (e.g., pH, temperature, light, electricity, and magnetic fields) for actuation purposes has been revealed by their performances in real-time biosensing systems, targeted drug delivery, artificial muscle reconstruction, and cell microenvironment engineering. In this review, the material selection of hydrogels with multiple stimulusresponsive mechanisms for actuator fabrication is first introduced, followed by a detailed introduction to and discussion of the most recent progress in emerging biomedical applications of hydrogel-based bioactuators. Final conclusions, existing challenges, and upcoming development prospects are noted in light of the status quo of bioactuators based on stimulus-responsive hydrogels.

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“…This provided a ‘bridge’ for the combination of hydrophobic drugs with hydrophilic materials. Chitosan, derived from chitin deacetylation, is a linear polysaccharide consisting of β ‐(1–4)‐linked d ‐glucosamine residues and N ‐acetylglucosamine groups and has been widely used in biomedical applications due to its biocompatibility, nontoxicity, bio‐activity, biodegradability, etc . In addition, chitosan is a polyelectrolyte with positive charge due to the presence of amino groups on the polyglycidic chain.…”

Section: Introductionmentioning

confidence: 99%

Dual pH‐ and thermal‐responsive nanocomposite hydrogels for controllable delivery of hydrophobic drug baicalein

Feng

Wang

et al. 2019

Polymer International

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Hydrogels have been widely used as mild biomaterials due to their bio‐affinity, high drug loading capability and controllable release profiles. However, hydrogel‐based carriers are greatly limited for the delivery of hydrophobic payloads due to the lack of hydrophobic binding sites. Herein, nano‐liposome micelles were embedded in semi‐interpenetrating poly[(N‐isopropylacrylamide)‐co‐chitosan] (PNIPAAm‐co‐CS) and poly[(N‐isopropylacrylamide)‐co‐(sodium alginate)] (PNIPAAm‐co‐SA) hydrogels which were responsive to both temperature and pH, thereby establishing tunable nanocomposite hydrogel delivery systems. Nano‐micelles formed via the self‐assembly of phospholipid could serve as the link between hydrophobic drug and hydrophilic hydrogel due to their special amphiphilic structure. The results of transmission and scanning electron microscopies and infrared spectroscopy showed that the porous hydrogels were successfully fabricated and the liposomes encapsulated with baicalein could be well contained in the network. In addition, the experimental results of response release in vitro revealed that the smart hydrogels showed different degree of sensitiveness under different pH and temperature stimuli. The results of the study demonstrate that combining PNIPAAm‐co‐SA and PNIPAAm‐co‐CS hydrogels with liposomes encapsulated with hydrophobic drugs is a feasible method for hydrophobic drug delivery and have potential application prospects in the medical field. © 2018 Society of Chemical Industry

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Chitosan-based polymer hybrids for thermo-responsive nanogel delivery of curcumin

Cited by 129 publications

References 45 publications

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Bioactuators based on stimulus-responsive hydrogels and their emerging biomedical applications

Dual pH‐ and thermal‐responsive nanocomposite hydrogels for controllable delivery of hydrophobic drug baicalein

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