Dual pH‐ and thermal‐responsive nanocomposite hydrogels for controllable delivery of hydrophobic drug baicalein

Feng, Shuangjiang; Wang, Shuxue; Lv, Yuanfei; He, Lei; Li, Qiurong; Zhang, Tao

doi:10.1002/pi.5738

Cited by 13 publications

(4 citation statements)

References 39 publications

(50 reference statements)

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“…Basically, PNIPAM hydrogels cannot load hydrophobic drugs efficiently due to the absence of hydrophobic binding sites. Feng et al embedded nano-liposome micelles in poly[(Nisopropylacrylamide)-co-chitosan] (PNIPAM-co-CS) or poly[(N-isopropylacrylamide)-co-(sodium alginate)] (PNIPAM-co-SA) hydrogels to form composite systems [94]. The liposome micelles can encapsulate hydrophobic species in their inner cores and thus greatly enhance the loading capacity for hydrophobic drugs ( Figure 3A).…”

Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

221

143

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Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications.

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Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

221

143

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“…Environmental responsive nanomaterials can release the packaged drugs and enhance the targeting of drugs [13] with changing in a specific environment, such as pH [14][15][16], temperature [17,18], response [19,20], etc. These environmental conditions can be used as stimulus signals to start the drug delivery system and the structure, morphology and physical and chemical properties of nanocapsules are changed by changing the environmental parameters.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Sun¹,

Yang²,

Xu³

et al. 2023

Nanotechnology

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The construction of an environmentally responsive drug-release system is of great significance for the treatment of special diseases. In particular, the construction of nanomaterials with pH- and thermal-responsiveness, which can effectively encapsulate drugs and control drug release, is becoming hot research. In this study, zwitterionic nanocapsules (ZNCs) with stable core-shell structures were synthesized by inverse reversible addition-fragmentation transfer (RAFT) miniemulsion interfacial polymerization. To further study the structure and performance of the nanocapsules, the prepared nanocapsules were characterized by transmission electron microscopy (TEM), dynamic light dispersion (DLS), and zeta potential analysis. It was found that the nanocapsules had dual pH- and thermal- responsiveness, and the average particle size ranged from 178 nm to 142 nm when the temperature changed from 25 ℃ to 40 ℃. In addition, bovine serum albumin (BSA) was encapsulated into nanocapsules, and sustained release experiments were conducted at 10 ℃ and 40 ℃. The results showed that nanocapsules as carriers of BSA could achieve the purpose of sustained release of drugs, and showed different sustained release curves at different temperatures. Finally, in vitro cytotoxicity tests were performed to demonstrate the feasibility of their biomedical application. It is believed that the dual pH- and thermal- responsive nanocapsules are promising for drug-controlled release.

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“…Various kinds of strategies have been followed to improve hydrogel mechanical properties, involving structural variations [ 31 , 32 ] or the introduction of discrete fillers [ 33 , 34 , 35 ]. A toughening of hydrogels can also be achieved through the construction of a double network (DN), which normally is composed of an asymmetrical interpenetrating network (IPNs) [ 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Thermo-Responsive Controllable Shape-Changing Hydrogel

Luo

Pauer

Luinstra

2022

Gels

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Temperature response double network (DN) hydrogels comprising a network formed by polymerization of methacrylic acid (MA) modified PVA, N,N’-methylene bis(acrylamide), N-isopropylacryl amide (NIPAM), and one formed from crystalline polyvinyl alcohol (PVA) are prepared in a 3D printed tailor-made mold. The (PVA-MA)-g-PNIPAAm thermoset intermediate is formed in water by a radical, photo-initiated process, and in the presence of dissolved PVA polymers. A subsequent freezing-thawing sequence induces the crystallization of the PVA network, which forms a second network inside the thermoset NIPAM polymer. The prepared hydrogel is thermoresponsive by the phase transition of PNIPAAm segments (T ≈ 32 °C) and has good mechanical properties (tensile strength 1.23 MPa, compressive strength 1.47 MPa). Thermal cycling between room temperature at 40 or 50 °C shows the product converses from a virgin-state to a steady-state, which most likely involves the reorganization of PVA crystals. The swelling-deswelling cycles remain clear at a length change of about 13%.

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Dual pH‐ and thermal‐responsive nanocomposite hydrogels for controllable delivery of hydrophobic drug baicalein

Cited by 13 publications

References 39 publications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Fabrication of Thermo-Responsive Controllable Shape-Changing Hydrogel

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