Chitosan-bacterial cellulose patch of ciprofloxacin for wound dressing: Preparation and characterization studies

Cacicedo, Maximiliano L.; Pacheco, Guilherme; Islan, Germán Abel; Álvarez, Vera A.; Barud, Hernane S.; Castro, Guillermo R.

doi:10.1016/j.ijbiomac.2019.10.082

Cited by 101 publications

(51 citation statements)

References 36 publications

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“…The ciprofloxacin release (approximately 70%) from the resultant films was achieved after the first hour indicating high antibacterial barrier for the first period of the treatment. The ciprofloxacin‐loaded films demonstrated a good antibacterial performance against PA and SA with the synergistic effect of CS 78 . The synergistic effect occurs when two or more antibacterial agents are used together resulting in the enhancement of the antibacterial activity.…”

Section: Antibioticsmentioning

confidence: 96%

Advancements and future directions in the antibacterial wound dressings – A review

et al. 2020

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Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, a major obstacle to wound repair, cause an elevated inflammatory responses and result in ultimate outcome of incomplete and prolonged wound repair. To overcome these shortcomings, there is a growing requirement for antibacterial wound dressings. Dressings with antibacterial activities and multifunctional behaviors are highly anticipated to avoid the wound infection for successful healing. The aim of this review is not only to concentrate on the importance of antibacterial dressings for wound healing applications but also to discuss recent studies and some future perspectives about antibacterial wound dressings.

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Section: Antibioticsmentioning

confidence: 96%

Advancements and future directions in the antibacterial wound dressings – A review

et al. 2020

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“…Another key factor concerning wound healing patches is represented by their waterrelated behaviour [50,51]. As a matter of fact, such systems must be able to absorb a great quantity of exudate to keep the tissue dry (i.e., having high hydrophilicity) and allow a sufficient gas and vapour permeability (i.e., having a high porosity), at the same time being able to be stored over a long time (i.e., having a low moisture content).…”

Section: Mechanical and Water-related Propertiesmentioning

confidence: 99%

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

et al. 2021

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Chitosan nanofibrous membranes are prepared via an electrospinning technique and explored as potential wound healing patches. In particular, the effect of a physical or chemical crosslinking treatment on the mat morphological, mechanical, water-related, and biological properties is deeply evaluated. The use of phosphate ions (i.e., physical crosslinking) allows us to obtain smooth and highly homogenous nanofibers with an average size of 190 nm, whereas the use of ethylene glycol diglycidyl ether (i.e., chemical crosslinking) leads to rougher, partially coalesced, and bigger nanofibers with an average dimension of 270 nm. Additionally, the physically crosslinked mats show enhanced mechanical performances, as well as greater water vapour permeability and hydrophilicity, with respect to the chemically crosslinked ones. Above all, cell adhesion and cytotoxicity experiments demonstrate that the use of phosphate ions as crosslinkers significantly improves the capability of chitosan mats to promote cell viability owing to their higher biocompatibility. Moreover, tuneable drug delivery properties are achieved for the physically crosslinked mats by a simple post-processing impregnation methodology, thereby indicating the possibility to enrich the prepared membranes with unique features. The results prove that the proposed approach may lead to the preparation of cheap, biocompatible, and efficient chitosan-based nanofibers for biomedical and pharmaceutical applications.

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“…A highly efficient dynamic culture method which retain nanofiber structure can be used to prepare CS/BC nanofiber hydrogel with high mechanical properties and great antibacterial activity against E. coli and S. aureus (Zhang et al, 2016). In addition, biopolymer blends based on BC membrane modified by low molecular weight chitosan (Chi) were developed for the controlled release of ciprofloxacin (CIP), and Chi had synergistic effect on CIP antibacterial activity (Cacicedo et al, 2020; Figure 7A). A novel hemostatic nanocomposite (OBC/COL/CS) was prepared by coupling oxidized bacterial cellulose (OBC), CS and collagen (COL) (Yuan et al, 2020; Figure 7B).…”

Section: Natural Polymersmentioning

confidence: 99%

“…The microencapsulation of curcumin in cyclodextrin (CD) has overcome the hydrophobicity of curcumin (Gupta et al, 2019). It has been studied that the compounds (cAgNP) containing Ag NPs were prepared with curcumin and hydroxypropyl-β-CD and then were loaded FIGURE 7 | (A) BC-Chi-CIP membrane for CIP controlled release with synergistic antibacterial effect of Chi and CIP (Cacicedo et al, 2020). (B) The preparation scheme of OBC/COL/CS hemostatic sponge with CS as antibacterial agent (Yuan et al, 2020).…”

Section: Natural Polymersmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

Luo

et al. 2020

Front. Bioeng. Biotechnol.

103

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At present, there are various wound dressings that can protect the wound from further injury or isolate the external environment in wound treatment. Whereas, infection and slow self-healing still exist in wound healing process. Therefore, it is urgent to develop an ideal wound dressing with good biocompatibility and strong antibacterial activity to promote wound healing. Bacterial cellulose is a kind of promising biopolymer because it can control wound exudate and provide a moist environment for wound healing. However, the lack of antibacterial activity limits its application. In this paper, the advantages of bacterial cellulose as wound dressings were introduced, and the preparation and research progress of bacterial cellulose-based antibacterial composites in recent years were reviewed, including adding antibiotics, combining with inorganic antibacterial agents or organic antibacterial agents. Finally, the existing problems and future development direction of bacterial cellulose-based antibacterial wound dressings were discussed.

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Chitosan-bacterial cellulose patch of ciprofloxacin for wound dressing: Preparation and characterization studies

Cited by 101 publications

References 36 publications

Advancements and future directions in the antibacterial wound dressings – A review

Advancements and future directions in the antibacterial wound dressings – A review

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

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