Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

Lu, Zheng; Li, Shanshan; Luo, Jiwen; Wang, Xiaoying

doi:10.3389/fbioe.2020.593768

Cited by 111 publications

(63 citation statements)

References 126 publications

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“…In fact, a number of studies have shown a high level of eradication of wound pathogens by antiseptic molecules released from BC, both in vitro and in vivo [ 54 , 55 , 56 , 57 , 58 ]. Further, an increasing number of such antiseptic-containing BC dressings are commercially available and applied in clinical practice [ 59 ]. Thus, we aimed to confirm that BC obtained from PJ media was also suitable in this context.…”

Section: Resultsmentioning

confidence: 99%

Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose

Ciecholewska-Juśko

Broda

Żywicka

et al. 2021

IJMS

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In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ). We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin–Schramm medium. The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment. Likewise, the macro- and microstructure, physicochemical parameters, and chemical composition showed no significant differences between PJ and control BC. Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities. The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic. These are very important aspects from an application standpoint, particularly in biomedicine. Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.

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Section: Resultsmentioning

confidence: 99%

Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose

Ciecholewska-Juśko

Broda

Żywicka

et al. 2021

IJMS

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“…In addition to barrier property, they would also have specific flexibility, applicability, constancy, biodegradability and be able to remove, pace the healing process, and decrease the risk of infection. 4 , 5 Today, the use of advanced mats comprising antibacterial properties is essential in preventing and treating wound infections. Despite the diversity of wound dressings in the market, highly exuding wounds are difficult to heal as dressings cannot efficiently inhibit the wound's microbial invasion.…”

Section: Introductionmentioning

confidence: 99%

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Bagheri

Validi

Gholipour

et al. 2021

Bioengineering & Transla Med

118

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Bacterial wound infection is one of the most common nosocomial infections.The unnecessary employment of antibiotics led to raising the growth of antibioticresistant bacteria. Accordingly, alternative armaments capable of accelerating wound healing along with bactericidal effects are urgently needed. Considering this, we fabricated chitosan (CS)/polyethylene oxide (PEO) nanofibers armed with antibacterial silver and zinc oxide nanoparticles. The nanocomposites exhibited a high antioxidant effect and antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Besides, based on the results of the cell viability assays, the optimum concentration of ZnONPs and AgNPs in the nanofibrous mats is 0.2% w/v and 0.08% w/v respectively and had no cytotoxicity on fibroblast cells. The scaffold also showed good blood compatibility according to the effects of coagulation time. As well as significant fibroblast migration and proliferation on the wound margin, according to wound-healing assay. All in all, the developed biocompatible, antioxidant, and antibacterial Ag-ZnO NPs incorporated CS/PEO nanofibrous mats showed their potential as an effective wound dressing.antibacterial, antioxidant, chitosan/polyethylene oxide nanofibers, electrospun, silver nanoparticles, wound healing, zinc oxide nanoparticles | INTRODUCTIONWound infection is a common and unsolved issue in preventing wound healing. Any kind of wound on the skin is susceptible to the accumulation of infectious bacteria. 1 With the spread of antibiotic-resistant bacteria, employing antibiotics to prevent and treat wound infections is inefficient.In addition, it imposes extra costs on the patient and society. Consequently, alternative materials are pivotal to combat pathogens. 2,3

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“…Dressings of injury, imitation skin, dental transplants, medication delivery, hemostatic constituents, vascular grafts, tissue engineering, biosensors, and diagnostics are just a few of the biomedical applications where BNC holds a lot of promise ( Figure 8 ) ( Rajwade et al, 2015 ; Anton-Sales et al, 2019 ; Carvalho et al, 2019 ). All biomedical applications necessitate BNC because of its high purity and biocompatibility ( Zheng et al, 2020 ). The endotoxin in BNC is likewise highly controlled, with less than twenty endotoxin units, which fulfills the FDA’s in vivo standards ( Petersen and Gatenholm, 2011 ).…”

Section: Resultsmentioning

confidence: 99%

The Trend of Bacterial Nanocellulose Research Published in the Science Citation Index Expanded From 2005 to 2020: A Bibliometric Analysis

Halim

Islam

2022

Front. Bioeng. Biotechnol.

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To gain insight into the trend of bacterial nanocellulose research, a bibliometric analysis was performed using the Science Citation Index Expanded database from 2005 to 2020. The study concentrated on the publication’s performance in terms of annual outputs and citations, mainstream journals, categories of the Web of Sciences, leading countries, prominent institutions, and trends in research. Current research priorities and future trends were analyzed after summarizing the most commonly used keywords extracted from words in the paper title analysis, authors’ keyword analysis, and KeyWords Plus. The findings revealed that the annual output in the form of scholarly articles on bacterial nanocellulose research steadily increased during the first quartile of the study period, followed by a very rapid increase in the last five-years of the study. Increasing mechanical strength would remain the main future focus of bacterial nanocellulose research to create its scope in different field of applications.

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Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

Cited by 111 publications

References 126 publications

Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose

Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

The Trend of Bacterial Nanocellulose Research Published in the Science Citation Index Expanded From 2005 to 2020: A Bibliometric Analysis

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