Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods

Cámara, Marı́a S.; Mastandrea, Carlos; Goicoechea, Héctor C.

doi:10.1016/j.jbbm.2005.07.001

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…[3]. Since CBZ administers commonly in combination with other anti-epilepsy drugs such as valproic acid and phenytoin, drug assay method in the serum would be valuable to minimize toxicity of the therapeutics in the patients [2]. Therefore, considerable interest has focused on developing effective analytical methods for assaying this compound in biological samples at low concentrations.…”

mentioning

confidence: 99%

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Esfandyari-Manesh

Javanbakht

Dinarvand

et al. 2012

J Mater Sci: Mater Med

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Water-compatible imprinted nanoparticles were prepared for carbamazepine as a template and used for the selective extraction and controlled release of carbamazepine. Assay materials and drug delivery carriers were typically used in aqueous environments, so it is generally preferable to prepare solvent-free molecularly imprinted nanoparticles in water using the miniemulsion polymerization method. The present work investigates a bio-analytical strategy generically applicable to imprinted materials for molecular recognition studies, including equilibrium and non-equilibrium binding, and release experiments, increasing the knowledge of the molecular interactions between the template molecules and imprinted nanoparticles. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles. The selectivity of imprinted nanoparticles for carbamazepine studied in comparison with an analogue compound, oxcarbazepine, the main metabolite of carbamazepine. The recovery and selectivity of carbamazepine in human serum was determined to be 100%, 1.7 times that of oxcarbazepine. The results indicated that carbamazepine-imprinted nanoparticles are appropriate for serum level determination of the drug in therapeutic range. The template to functional monomer ratio as a key factor controlling the recognition and release kinetic mechanism of imprinted nanoparticles is discussed. The imprinted nanoparticles prepared at the appropriate template to functional monomer mole ratio (2:8) exhibited the best drug affinity (5.1 times higher) and a slower drug release rate due to the interaction of carbamazepine with the imprinted cavities within the nanoparticles. Loaded imprinted nanoparticles as drug reservoirs were able to prolong carbamazepine release, in 1% wt sodium dodecyl sulfate aqueous solution, for more than 8 days.

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mentioning

confidence: 99%

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Esfandyari-Manesh

Javanbakht

Dinarvand

et al. 2012

J Mater Sci: Mater Med

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“…These samples were then transferred to Costar clear 96-well plates and analyzed using a UV detector (SpectraMax M2, Molecular Devices, Pennsylvania, USA). Drug concentrations in the dissolution samples were determined based upon linear concentration-absorbance plots generated at 285, 250, 271, and 265 nm for CBZ, PHT, HCTZ, and CPM, respectively (24)(25)(26)(27).…”

Section: Dissolution Studiesmentioning

confidence: 99%

Low-Viscosity Hydroxypropylcellulose (HPC) Grades SL and SSL: Versatile Pharmaceutical Polymers for Dissolution Enhancement, Controlled Release, and Pharmaceutical Processing

Sarode

Wang

Cote³

et al. 2012

AAPS PharmSciTech

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Abstract. Hydroxypropylcellulose (HPC)-SL and -SSL, low-viscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. The utility of HPC polymers was assessed for both dissolution enhancement and sustained release of pharmaceutical drugs using various processing techniques. The BCS class II drugs carbamazepine (CBZ), hydrochlorthiazide, and phenytoin (PHT) were hot melt mixed (HMM) with various polymers. PHT formulations produced by solvent evaporation (SE) and ball milling (BM) were prepared using HPC-SSL. HMM formulations of BCS class I chlorpheniramine maleate (CPM) were prepared using HPC-SL and -SSL. These solid dispersions (SDs) manufactured using different processes were evaluated for amorphous transformation and dissolution characteristics. Drug degradation because of HMM processing was also assessed. Amorphous conversion using HMM could be achieved only for relatively low-melting CBZ and CPM. SE and BM did not produce amorphous SDs of PHT using HPC-SSL. Chemical stability of all the drugs was maintained using HPC during the HMM process. Dissolution enhancement was observed in HPC-based HMMs and compared well to other polymers. The dissolution enhancement of PHT was in the order of SE>BM>HMM>physical mixtures, as compared to the pure drug, perhaps due to more intimate mixing that occurred during SE and BM than in HMM. Dissolution of CPM could be significantly sustained in simulated gastric and intestinal fluids using HPC polymers. These studies revealed that low-viscosity HPC-SL and -SSL can be employed to produce chemically stable SDs of poorly as well as highly water-soluble drugs using various pharmaceutical processes in order to control drug dissolution.

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“…Figure 1 shows the chemical structures of all the studied drugs. Literature survey revealed many of the methods with different analytical techniques including spectrophotometry, spectrofluorimetry, high performance liquid chromatography, capillary electrophoresis, FT-IR Raman spectrometry, chemiluminescene, flow injection analysis, voltametry and so on for alone or simultaneous determination of PCT [14][15][16][17][18], CBZ [19][20][21][22][23][24][25], LSR [26][27][28][29][30] and CIP [31][32][33][34][35][36] in dosage formulation and in body fluids. …”

Section: Introductionmentioning

confidence: 99%

An Ultra-sensitive LC Method for the Simultaneous Determination of Paracetamol, Carbamazepine, Losartan and Ciprofloxacin in Bulk Drug, Pharmaceutical Formulation and Human Serum by Programming the Detector

Sultana¹,

Arayne²,

Ali³

2013

AJAC

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An ultra-sensitive LC method for the simultaneous quantitation of paracetamol, carbamazepine, losartan and ciprofloxacin have been developed and validated following the ICH guidelines at isobestic point and by programming the detector at individual wavelength of each component. −1 respectively. Percent recoveries > 98.37% from pharmaceutical formulation and human serum samples and RSD < 2% for inter-day and intra-day assay were obtained. The method was found to be robust and can be successfully applied for the determination of studied drugs in, pharmaceutical formulations and human serum without interference of excipients or endogenous components of serum.

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Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods

Cited by 21 publications

References 27 publications

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Low-Viscosity Hydroxypropylcellulose (HPC) Grades SL and SSL: Versatile Pharmaceutical Polymers for Dissolution Enhancement, Controlled Release, and Pharmaceutical Processing

An Ultra-sensitive LC Method for the Simultaneous Determination of Paracetamol, Carbamazepine, Losartan and Ciprofloxacin in Bulk Drug, Pharmaceutical Formulation and Human Serum by Programming the Detector

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