ChemInform Abstract: Synthesis of Novel Substituted 7‐(Benzylideneamino)‐4‐methyl‐2H‐chromen‐2‐one Derivatives as Antiinflammatory and Analgesic Agents.

Abstract

Antiinflammatory activity X 0130 Synthesis of Novel Substituted 7-(Benzylideneamino)-4-methyl-2H-chromen--2-one Derivatives as Antiinflammatory and Analgesic Agents. -Among a series of title compounds the derivatives (I) exhibit potent antiinflammatory and analgesic activity. -(RONAD*, P.; DHARBAMALLA, S.; HUNSHAL, R.; MADDI, V.; Arch. Pharm. (Weinheim, Ger.) 341 (2008) 11, 696-700; Dep. Pharm. Chem., KLE Coll. Pharm., Karnataka 575 025, India; Eng.) -H. Haber

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

“…On this basis, Levai et al [19] have recently described only the synthesis of 1-substituted-5-aryl-3-(3-coumarinyl)-2-pyrazolines by the reaction of (3-coumarinyl)-chalcones and hydrazines. In view of these observations and in continuation of our research programme on the synthesis of heterocyclic compounds [20][21][22][23], we report herein the synthesis of some new 2-pyrazoline derivatives, which have been found to possess an interesting profile of anti-inflammatory, analgesic and antipyretic activities along with significantly less ulcerogenic potential.…”

Synthesis and pharmacological evaluation of schiff bases of 7-amino-4-methyl coumarins as novel anti-inflammatory agents

“…Synthesis: (Rama Ganesh et al, 2010;Ronad et al, 2008;Robinson, 1990;Pretka and Wilmington, 1961) 1. Synthesis of N-(4-methyl-2-oxo-2 -chromene-7-yl) H hydrazine carboxamide [III]:…”