2019
DOI: 10.31024/ajpp.2019.5.4.7
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Synthesis and pharmacological evaluation of schiff bases of 7-amino-4-methyl coumarins as novel anti-inflammatory agents

Abstract: Objective: The present investigation involves the synthesis and examination of anti-inflammatory activity of schiff bases of 7-amino-4-methyl-coumarins in different experimentally induced inflammatory models. in-vivo Materials and methods: The compounds were synthesized by reaction of 7-amino-4-methyl-coumarin with ethyl chloroformate to obtain 7-urethane-4-methyl-benzopyran-2-one. This was further condensed with hydrazine hydrate to obtain N-(4methyl-2-oxo-2H-chromen-7-yl) hydrazine carboxamide, which was ref… Show more

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Cited by 5 publications
(2 citation statements)
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“…In accordance with the literature, scopoletin and umbelliferone (which exhibit a dual inhibitory activity against COX-2 and 5-LO [100]) suppress the synthesis of inflammatory mediators (histamine and serotonin), pro-inflammatory cytokines (IL-1β, TNF-α), leukotrienes, and other biological substances, which decreases the microvasculature vessel permeability and prevents blood plasma exudation, local edema development, blood cell migration, and infiltrated cell development [88,89,[101][102][103]. In addition, coumarins reduce myeloperoxidase concentration and suppress neutrophil chemotaxis [92,104]. The reduced gastric mucosa inflammation is accompanied by an increase in somatostatin secretion and a reduction in gastrin secretion.…”
Section: Discussionmentioning
confidence: 99%
“…In accordance with the literature, scopoletin and umbelliferone (which exhibit a dual inhibitory activity against COX-2 and 5-LO [100]) suppress the synthesis of inflammatory mediators (histamine and serotonin), pro-inflammatory cytokines (IL-1β, TNF-α), leukotrienes, and other biological substances, which decreases the microvasculature vessel permeability and prevents blood plasma exudation, local edema development, blood cell migration, and infiltrated cell development [88,89,[101][102][103]. In addition, coumarins reduce myeloperoxidase concentration and suppress neutrophil chemotaxis [92,104]. The reduced gastric mucosa inflammation is accompanied by an increase in somatostatin secretion and a reduction in gastrin secretion.…”
Section: Discussionmentioning
confidence: 99%
“…To study in vivo anti‐inflammatory properties, Jaya Krishna et al [ 101 ] synthesized urea derivatives of 7‐amino‐4‐methylcoumarins. The synthesized compounds 97–99 (Table 13) were tested for inhibition of edema induced by histamine, carrageenan, and formalin at a concentration of 50 mg/kg.…”
Section: Carbonic Anhydrase Inhibitors and Anticancer Activitymentioning
confidence: 99%