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Objective: The present investigation involves the synthesis and examination of anti-inflammatory activity of schiff bases of 7-amino-4-methyl-coumarins in different experimentally induced inflammatory models. in-vivo Materials and methods: The compounds were synthesized by reaction of 7-amino-4-methyl-coumarin with ethyl chloroformate to obtain 7-urethane-4-methyl-benzopyran-2-one. This was further condensed with hydrazine hydrate to obtain N-(4methyl-2-oxo-2H-chromen-7-yl) hydrazine carboxamide, which was refluxed with substituted aromatic aldehydes to form schiff base (IVa-c). The structure of the newly synthesized compounds was confirmed by spectral data. The invivo anti-inflammatory activity of synthetic compounds was carried out using acute anti-inflammatory models (Histamine, Carrageenan and Formalin induced paw oedema) and sub-acute anti-inflammatory model (Cotton pellet granuloma). The results showed that treatment with the coumarin derivatives (50 mg/kg) Results and conclusion: significantly inhibit the acute and sub-acute anti-inflammatory models when compared with the control treated rats. The present study suggests that the coumarin derivatives possess anti-inflammatory activity in different experimentally induced inflammatory models.