Novel 3-coumarinyl substituted pyrazolines of type (III) are evaluated for their biological activities (anti-inflammatory, analgesic, antipyretic, ulcerogenic). Selected compounds, e.g. (IIIa)-(IIId), show significant anti-inflammatory and analgesic effects. -(KHODE, S.; MADDI*, V.; ARAGADE, P.; PALKAR, M.; RONAD, P. K.; MAMLEDESAI, S.; THIPPESWAMY, A. H. M.; SATYANARAYANA, D.; Eur.
A novel series of 3-[3-(substituted phenyl)-1-isonicotinoyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives 4a-k have been synthesized by the reaction of 3-[2,3-dibromo-3-(substituted phenyl) propanoyl]-2H-chromen-2-one 3a-k and isonicotinic acid hydrazide in the presence of triethylamine in absolute ethanol, characterized by spectral data and screened for their in-vitro antibacterial activity against Gram-positive and Gram-negative bacteria. Among the series, compounds 4e, 4i, and 4k displayed an encouraging antibacterial activity profile as compared to the reference drug ampicillin against tested bacterial strains.
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