ChemInform Abstract: Antioxidative and Hepatoprotective Activity of Water‐Soluble 4‐Propylphenols Containing a Hydrophilic Group in the Alkyl Chain (I).

Кандалинцева, Н. В.; Dyubchenko, O. I.; Terakh, E. I.; Просенко, А. Е.; Shvаrts, Ya. Sh.; Душкин, М. И.

doi:10.1002/chin.200234093

Cited by 3 publications

(4 citation statements)

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“…The following chemicals have been used in the current study: antioxidants -tBHQ, 3-(3'tert-butyl-4'-hydroxyphenyl)ethylthiosulfonate Na (TS-12), 3-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate Na (TS-13), 4-(3'-tert-butyl-4'-hydroxyphenyl) butylthiosulfonate Na (TS-14). Synthesis and chemical properties of these compounds have been described previously [15][16][17]. Animal treatment BALB male mice were provided with food containing corresponding phenolic derivatives (0.6% of the food mass).…”

Section: Reagents and Chemicalsmentioning

confidence: 99%

Effect of ethylthiosulfаnylate and Chrome(VI) on the pro/antioxidant system in rats blood

Kotyk¹,

Iskra²,

Sushko³

et al. 2019

Bìol. Tvarin

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Synthetic water-soluble phenolic antioxidants are known anti-inflammatory chemicals, some of them were shown to induce components of antioxidative defense enzymes NADPH:quinone oxidoreductase (NQO1) and glutathione-S-transferase (GST) via activation of Nrf2 pathway. Our experimental in vivo models have demonstrated an increase of both gstp1 and nqo1 expression in the liver of mice treated with novel organosulfur phenolic compounds TS-12, TS-13, TS-14. Both expression and activity of GSTP1 was dependent on the distance of active thiosulfonate group in para-position from the benzene ring of the above antioxidants. The increase of nqo1 and gstp1 gene expression was mediated by the antioxidant-binding response element (ARE). Our results revealed the role of Nrf2/ARE-dependent transcription regulation in response to the new phenolic antioxidants and suggested possible strategy to improve antioxidative properties of synthetic phenolic compounds.

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Section: Reagents and Chemicalsmentioning

confidence: 99%

Effect of ethylthiosulfаnylate and Chrome(VI) on the pro/antioxidant system in rats blood

Kotyk¹,

Iskra²,

Sushko³

et al. 2019

Bìol. Tvarin

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“…Kerusakan hati yang diawali dengan meningkatnya steatosis dan fibrosis pada hati yang dalam kondisi kronis dapat menyebabkan kematian. Salah satu mekanisme patogenesis kerusakan hati adalah degradasi membran hepatosit yang dikarenakan oleh peroksidasi lemak (Kandalintseva et al, 2002). Reaksi peroksidasi dapat dipicu oleh paparan spesies oksigen reaktif (SOR) (Poli & Parola 1997).…”

Section: Pendahuluanunclassified

“…Kondisi dan struktur membran sel berperan penting dalam melawan efek SOR. Asam lemak tidak jenuh pada membran sel dapat mengalami peroksidasi oleh SOR yang berakibat pada penurunan integritas dan fungsi membran sel dan akhirnya berimplikasi pada perubahan patologis yang serius (Halliwell 1987;Kandalintseva et al, 2002). Sistem fisiologis tubuh mempunyai kemampuan mengurangi kerusakan sel-sel oleh peroksidasi (Sies 1993).…”

Section: Pendahuluanunclassified

Efek Hepatoprotektif Ekstrak Buah Merah (Pandanus conoideus Lam.) pada Hati Mencit Jantan Galur Swiss induksi dengan CCl4

2012

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A research on red fruit (Pandanus conoideus Lam.) has been conducted to determine its hepatoprotective effect. This research was concern on three group of treatments, a blank treatment (water), a standard drug (curcumine containing) and red fruit extract treatment group. The liver destruction was induced by CCl 4 . The hepatoprotective effect was illustrated by SGOT -SGPT level of activity and percentage of cell destruction obtained from histopatogolic analysis. Compared to the blank group, which had level of SGOT-SGPT activity as 38224,40  2,92 U/L and SGPT of 24128,00  5,22 U/L, the red fruit treatment group showed a lower SGOT -SGPT activity (20112,4  2,68 U/L and 18923,0  2,77 U/L, respectively); while the standard drug treatment group showed level of SGOT and SGPT activity as 29732,4  1,85 U/L and 20640,8  3,78 U/L, respectively. The histopatologic evaluation also illustrated similarity that the red fruit treatment group occupied the lowest percentage of hepatocyte destruction shown as percentage of cell degeneration and cell necrosis of 28,3% and 31,7%, respectively. The standard drug treatment showed 78,3% of destruction based on degenerative cell destruction and 88,3% based on cell necrosis. Almost 100% of cell destruction was shown in the blank group. Based on these result, the red fruit extract possessed a liver cell protection activity against cell destruction caused by CCl4 exposure and even more active than a standard drug.

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“…Многие тиоалкил-и аминоалкилфенолы являются эффективными биоантиоксидантами и проявляют защитные свойства в отношении свободнорадикальных патологий [1]. В частности, 2,6-ди-трет-бутил-4-пропилфенолы, содержащие в пара-заместителе изотиурониевые и аммонийные группы, проявляют гепатопротекторную активность [2][3], а сульфидную группутакже противовирусные, антиканцерогенные, противоопухолевые и цитостатикпротекторные свойства [4][5][6][7][8].…”

unclassified

Oxidation of some sulfur- and nitrogen-containing alkylphenols with hydroperoxides

Valer’evna¹,

Ivanovna²,

Rashidovna³

et al. 2015

NSPU Bulletin

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Изучены окислительные превращения 2,6-ди-трет-бутил-4-пропил(этилтиопропил)фенолов, содержащих в пара-заместителе изотиурониевые и алкиламинные группы, под действием гидропероксида водорода и гидропероксида кумола. Показано, что при переходе от диалкилсульфидных к триалкиламинным и далее к изотиурониевым группам возрастает устойчивость к окислительному действию пероксидов. Нагреванием хлорида S-(2-(3-(3,5-ди-трет-бутил-4гидроксифенил)пропилтио)этил)изотиурония и N,N-диметил-2-(3-(3,5-ди-трет-бутил-4гидроксифенил)пропилтио)этиламина с гидропероксидами получены соответствующие сульфинильные производные, в то время как окисление N,N-диметил-3-(3,5-ди-трет-бутил-4гидроксифенил)пропиламина в аналогичных условиях с практически количественным выходом приводило к соответствующему N-оксиду. В то же время хлорид S-(3-(3,5-ди-трет-бутил-4гидроксифенил)пропил)изотиурония был устойчив к действию гидропероксидов к кислой и нейтральной средах, а в присутствии щелочи окислялся в бис-(3-(3,5-ди-трет-бутил-4-гидроксифенил)пропил)дисульфид. Все продукты окисления выделены в чистом виде и охарактеризованы спектральными методами.

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ChemInform Abstract: Antioxidative and Hepatoprotective Activity of Water‐Soluble 4‐Propylphenols Containing a Hydrophilic Group in the Alkyl Chain (I).

Cited by 3 publications

References 0 publications

Effect of ethylthiosulfаnylate and Chrome(VI) on the pro/antioxidant system in rats blood

Effect of ethylthiosulfаnylate and Chrome(VI) on the pro/antioxidant system in rats blood

Efek Hepatoprotektif Ekstrak Buah Merah (Pandanus conoideus Lam.) pada Hati Mencit Jantan Galur Swiss induksi dengan CCl4

Oxidation of some sulfur- and nitrogen-containing alkylphenols with hydroperoxides

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