Efek Hepatoprotektif Ekstrak Buah Merah (Pandanus conoideus Lam.) pada Hati Mencit Jantan Galur Swiss induksi dengan CCl4

Abstract

A research on red fruit (Pandanus conoideus Lam.) has been conducted to determine its hepatoprotective effect. This research was concern on three group of treatments, a blank treatment (water), a standard drug (curcumine containing) and red fruit extract treatment group. The liver destruction was induced by CCl 4 . The hepatoprotective effect was illustrated by SGOT -SGPT level of activity and percentage of cell destruction obtained from histopatogolic analysis. Compared to the blank group, which had level of SGOT-SGPT activity as 38224,40  2,92 U/L and SGPT of 24128,00  5,22 U/L, the red fruit treatment group showed a lower SGOT -SGPT activity (20112,4  2,68 U/L and 18923,0  2,77 U/L, respectively); while the standard drug treatment group showed level of SGOT and SGPT activity as 29732,4  1,85 U/L and 20640,8  3,78 U/L, respectively. The histopatologic evaluation also illustrated similarity that the red fruit treatment group occupied the lowest percentage of hepatocyte destruction shown as percentage of cell degeneration and cell necrosis of 28,3% and 31,7%, respectively. The standard drug treatment showed 78,3% of destruction based on degenerative cell destruction and 88,3% based on cell necrosis. Almost 100% of cell destruction was shown in the blank group. Based on these result, the red fruit extract possessed a liver cell protection activity against cell destruction caused by CCl4 exposure and even more active than a standard drug.

AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL REBUNG BAMBU KUNING (Bambusa vulgaris Schard) PADA TIKUS PUTIH JANTAN GALUR WISTAR

“…Hati yang sudah rusak sulit sekali untuk kembali normal seperti semula 2 . Kesehatan hati harus selalu dijaga karena hati merupakan organ sentral dalam metabolisme tubuh 3 . Prevalensi kerusakan hati di dunia menunjukkan jumlah yang serius untuk diwaspadai bahkan daerah kecil pun, kejadian kerusakan hati menunjukkan jumlah yang cukup tinggi terjadi secara periodik 1 .…”

Potensi Antioksidan Pada Buah Lokal Papua

“…Ekstrak buah merah juga dilaporkan memiliki efek hepaprotektif. Penelitian yang dilakukan oleh Nugraha et al (2008) melaporkan bahwa ektrak buah merah mencegah nekrosis sel hati pada mencit jantan yang diberi perlakuan CCl 4 . Hal tersebut diidentifikasi dengan menurunnya aktivitas enzim SGPT dan SGOT.…”