Chemical characterization of Centaurium erythrea L. and its effects on carbohydrate and lipid metabolism in experimental diabetes

Effect of Centaurium erythraea Rafn, Artemisia herba-alba Asso and Trigonella foenum-graecum L. on liver fat accumulation in C57BL/6J mice with high-fat diet-induced type 2 diabetes

“…Recently Stefkov et al (2014) identified groups of bitter compounds (flavonoids, iridoids and xanthones) in the methanol extract of the aerial parts of the CE that may have an influence on the expressed antihyperglycemic effect in streptozotocin rats.…”

“…erythraea Rafn (CE) has been used in traditional medicine for its depurative, sedative, antipyretic and anti-inflammatory effects (Kumarasamy et al, 2003;Valentao et al, 2001Valentao et al, , 2002. CE is also used in the treatment of diabetes (Hamza et al, 2010(Hamza et al, , 2011Stefkov et al, 2014). A. herba-alba Asso (AHA) is also used for the treatment of diabetes, for its antihyperglycemic (Al-Khazraji et al, 1993;Al-Shamaony et al, 1994;Hamza et al, 2010;Mansi et al, 2007;Marrif et al, 1995;Stefkov et al, 2014;Testekin et al, 2007) and hypoglycemic effect (Hamza et al, 2011).…”

“…CE is also used in the treatment of diabetes (Hamza et al, 2010(Hamza et al, , 2011Stefkov et al, 2014). A. herba-alba Asso (AHA) is also used for the treatment of diabetes, for its antihyperglycemic (Al-Khazraji et al, 1993;Al-Shamaony et al, 1994;Hamza et al, 2010;Mansi et al, 2007;Marrif et al, 1995;Stefkov et al, 2014;Testekin et al, 2007) and hypoglycemic effect (Hamza et al, 2011). T. foenum-graecum L. (TFG) has been traditionally used in the treatment of diabetes but most models on which TFG was tested were experimentally induced by streptozotocin or alloxan, which results in models closer to type 1 diabetes than the type 2 diabetes that is the most prevalent in human adults (Abdel-Barry et al, 1997;Ajabnoor and Tilmisany, 1988;Broca et al, 1999;Hannan et al, 2007;Khosla et al, 1995;Mowla et al, 2009;Vats et al, 2003;Zia et al, 2001).…”

In vitro culture type and elicitation affects secoiridoid and xanthone LC–ESI–TOF MS profile and production in Centaurium erythraea

“…Secoiridoid glycosides and xanthones have been reported as characteristic secondary metabolites in C. erythraea (Aberham et al 2011;Piatczak et al 2011;Stefkov et al 2014). In this study amount of secoiridoid glycosides and xanthones was assessed for the first time in C. erythraea in vitro shoot, cell suspension and callus cultures in comparison with wild plants.…”

“…In addition, it also exhibits antioxidative, antibacterial, antifungal, anti-diabetic and diuretic activity (reviewed by European Medicines Agency 2016). Pharmacological properties have mainly been attributed to high content of secoiridoid glycosides, iridoids and xanthones (Andrade et al 1998;Aberham et al 2011;Piatczak et al 2011;Stefkov et al 2014;Š iler 2012;Š iler et al 2014).…”