A Comprehensive Pharmacological Appraisal of Indian Traditional Medicinal Plants with Anti-diabetic Potential

Acharya, Chandan Kumar; Das, Balaram; Madhu, Nithar Ranjan; Sau, Somnath; De, Manna; Sarkar, Bhanumati

doi:10.1007/978-981-19-0027-3_8

Cited by 14 publications

(4 citation statements)

References 80 publications

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“…The antioxidant potential of poyherbal formulation will probably cause reduction in oxidative stress in prediabetic and diabetic patients. The presence of poly phenols in PHF enhances antioxidant activity in diabetics [29].…”

Section: Physicochemical Studies Of Polyherbal Formulationmentioning

confidence: 99%

Phytochemical Quantification and Characterization of Anti- Diabetic Potential of Polyherbal Formulation by FT-IR and GC-MS Analysis

Akram M.,

Sohail,

Sarfraz

et al. 2023

PJAEC

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The main objective of the present study was to develop and evaluate anti-diabetic potential of polyherbal formulation (PHF) using Nigella sativa, Cinnamomumverum, Allium sativum, Zingiberofficinale, Curcuma longa and Trigonellafoenumgraecum for management of diabetes. The PHF was investigated by advanced analytical techniques. The proximate analysis of PHF revealed all parameters were within the limits indicating no adulteration and contamination. In addition, gas chromatography-mass spectrometry (GC-MS) and Fourier transform-infrared (FT- IR) spectroscopy analysis showed the presence of bio-active phytochemicals including phenolic compounds, antioxidants, anti-inflammatory and anti-diabetic constituents that are good therapeutic potential for prevention and management of diabetes. The efficacy of PHF was evaluated by dividing into four groups (PHF 1.5 g, PHF 3.0 g, metformin 500 mg and placebo) of newly diagnosed type 2 diabetic patients for 90 consecutive days and monitored on a monthly basis. PHF 3.0 g dose showed a significantly higher anti-diabetic effect as compared to PHF 1.5 g while comparable results in relation to metformin 500 mg. The phytochemical characterization of PHF will ensure its quality and safety. Moreover, the anti-diabetic efficacy of PHF is comparable with anti-diabetic efficacy of metformin. PHF has the potential to achieve glycemic control in type 2 diabetic patients with a diabetic diet prescribed.

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Section: Physicochemical Studies Of Polyherbal Formulationmentioning

confidence: 99%

Phytochemical Quantification and Characterization of Anti- Diabetic Potential of Polyherbal Formulation by FT-IR and GC-MS Analysis

Akram M.,

Sohail,

Sarfraz

et al. 2023

PJAEC

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“…(SIRT1) is an important protein encoded by the gene of the same name that takes part in the metabolism of glucose and fat in the body (Moynihan et al, 2005;Purushotham et al, 2009;Chuang et al, 2011;Hasegawa et al, 2013;Chakrovorty et al, 2021;Acharya et al, 2023;Sarkar et al, 2023;Pawar et al, 2023). In various in vivo and in vitro diabetic nephropathy models, reduced SIRT1 gene expression in diabetic kidney tissues was correlated with the severity of proteinuria (Susztak et al, 2006;Nihalani and Susztak, 2013), and an increase in SIRT1 was associated with improvement in renal lesions (Hasegawa, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Borreria hispida Extract on SIRT1, HIF-1α, ET-1 and VEGFR-2 Gene Expression in NRK-52E Cells Subjected to Glucotoxicity

Markandeyan,

Ahmed,

Perumal

et al. 2024

IJERR

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This study aimed to investigate the impact of Borreria hispida extract on gene expression in NRK-52E cells under conditions of glucotoxicity. Gene expression analysis was conducted using RT-PCR following the exposure of cultured NRK-52E cells to glucotoxic conditions and varying concentrations of Borreria hispida extract. The results demonstrated a dose-dependent increase in SIRT1 gene expression and a concomitant decrease in HIF-1λ, ET-1, and VEGFR-2 gene expressions upon treatment with Borreria hispida extract. Additionally, molecular docking studies suggested the potential inhibition of Rho-kinase as a mechanistic explanation for these effects. Borreria hispida extract may confer renoprotective benefits against glucotoxicity-induced cellular damage. The potential therapeutic utility of Borreria hispida extracts in managing renal complications associated with conditions such as diabetes. Furthermore, our docking studies shed light on the potential molecular mechanisms underlying the observed effects, suggesting interactions between phytochemicals present in Borreria hispida extract and the JNK-1 protein. These interactions may contribute to the augmentation of SIRT1 activity, further bolstering the extract's therapeutic utility in DKD.

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“…Indigenous medicinal plants were present and still hold potential as sources of modern medications [ [1] , [2] , [3] , [4] , [5] , [6] ]. Significantly, the popularity of using phytotherapy as an alternative form of treatment has increased interest in the pharmacognosy of tropical plants [ 2 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities

Donkor,

Ahenkorah,

Wallah

et al. 2023

Heliyon

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A Comprehensive Pharmacological Appraisal of Indian Traditional Medicinal Plants with Anti-diabetic Potential

Cited by 14 publications

References 80 publications

Phytochemical Quantification and Characterization of Anti- Diabetic Potential of Polyherbal Formulation by FT-IR and GC-MS Analysis

Phytochemical Quantification and Characterization of Anti- Diabetic Potential of Polyherbal Formulation by FT-IR and GC-MS Analysis

Effect of Borreria hispida Extract on SIRT1, HIF-1α, ET-1 and VEGFR-2 Gene Expression in NRK-52E Cells Subjected to Glucotoxicity

Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities

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