Effect of Centaurium erythraea Rafn, Artemisia herba-alba Asso and Trigonella foenum-graecum L. on liver fat accumulation in C57BL/6J mice with high-fat diet-induced type 2 diabetes

Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health

“…In the first study, mice were given a daily oral gavage of a hydro-alcoholic fenugreek extract (2 g/kg daily) for 18–20 weeks 28 . In these experiments, they observed decreased serum glucose, insulin and TAG levels, and less insulin resistance as calculated by HOMA-IR 29 . The second study used the same dose and delivery method for 20 weeks and liver lipid accumulation was assessed.…”

“…Some evidence exists that fenugreek protects against hepatic steatosis 14 – 18 , while other evidence supports the contrary 29 . Since fenugreek supplementation altered the LDL and HDL ratio, but did not alter total cholesterol levels, it was important to determine if whole fenugreek seed supplementation prevented hepatic lipid accumulation and synthesis.…”

“…We also examined insulin secretion and lipid accumulation in liver as well as adiponectin expression in subcutaneous adipose tissue. To date, there are only two other studies by one research group that have used the highly studied C57BL/6J mouse model to examine anti-diabetic effects of fenugreek 28 , 29 . These studies relied on fasting glucose/insulin levels and HOMA-IR as a proxy for insulin resistance.…”

Ethnobotanical Survey of Medicinal Plants Used for the Treatment of Diabetes in the Tizi n’ Test Region (Taroudant Province, Morocco)

“…These species include Trigonella foenum-graecum [48][49][50], Artemisia herbaalba [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69], Juglans regia [60], Lavandula maroccana [24,39], Salvia lavandulifolia [61], Olea europaea [21, 24,38,39,52,54,62,63], Citrullus colocynthis [64][65][66], Nigella [67,68], Argania spinosa [47,69], Ajuga iva [70,71], Capparis spinosa [72], Cistus laurifolius [73], Teucrium polium [74], Ziziphus lotus [75], Zea mays [76] and Hibiscus sabdariffa [63]. To the best of our knowledge, Cistus creticus and Cladanthus scariosus are mentioned for the first time for treating diab...…”

Phenolic extracts of Centaurium erythraea with novel antiradical, antibacterial and antileishmanial activities

“…Moreover, in contrary to other studies [37,54], L. major promastigotes has appeared more sensitive than L. infantum. Previous studies have ascertained the antioxidant, ant-diabetic, anti-hyperglycemic and hepatoprotective activities of this medicinal plant [28,32,47,55], but only scarce data on their leishmanicidal activity are available. To our knowledge, our report is the first to deal with leishmaniacidal activity of C. erythraea on promastigote cultures of L. major, L. infantum and L. tropica.…”