Characterization of the humoral immune response to bovine collagen implants

Adverse reactions to injectable soft tissue fillers

“…21 Additional rare hypersensitive reactions include the formation of foreign body granulomas, 7,[22][23][24][25] palisading granulomas resembling granuloma annulare at the test site injections 26,27 (one of these patients had a history of granuloma annulare and the reaction at the site injection might also be caused by Koebner phenomenon 27 ), and cyst or abscess formation. 28 Rare examples of disseminated and recurrent sarcoid-like granulomatous panniculitis caused by bovine collagen injection have also been described. 29 Some authors differentiated a palisading granuloma (Fig 2), occurring mainly 2 or 3 months after injection and located in the mid to reticular dermis, from a diffusely organized granuloma, which was more frequent within the first 2 weeks and located in the reticular dermis and the subcutaneous tissue.…”

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

“…Delayed hypersensitivity response or severe anaphylactic shocks due to the collagen product are feared and serious side effects [44]. Rare hypersensitive reactions include the formation of foreign body granulomas at the injection site [45,46], as well as cyst or abscess formation and necrosis [42,47]. Therefore, a skin test is required 4 weeks before injection with bovine collagen [48,49].…”

Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy

“…High levels of anti-bovine collagen antibodies (principally igG) have been found in patients treated with clinical doses of injectable collagen from bovine dermis, whether or not, as in some cases, they presented undesirable local cutaneous symptoms (McCoY et al, 1985). No cross-reaction of these antibodies to human collagen (types i, ii or iii) could be shown (CoOPERMAN and MICHAELI, 1984;ELLINGWORTH et al, 1986).…”