Adverse reactions to injectable soft tissue fillers

Requena, Luis; Requena, Celia; Christensen, Lise; Zimmermann, U.; Kutzner, Heinz; Cerroni, Lorenzo

doi:10.1016/j.jaad.2010.02.064

Cited by 280 publications

(280 citation statements)

References 283 publications

(296 reference statements)

Supporting

Mentioning

237

Contrasting

Unclassified

Order By: Relevance

“…The most common substance seen in this series was hydroxyapatite with it's distinctive spheroids [12]. Less commonly used fillers have also been reported to induce foreign body reactions [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Lip Augmentation Dermal Filler Reactions, Histopathologic Features

Eversole

Tran²,

Hansen³

et al. 2013

Head and Neck Pathol

View full text Add to dashboard Cite

Instances of perioral and labial foreign body reactions to a variety of injectable dermal fillers were selected from the oral and maxillofacial pathology and dermatopathology archives at Pacific Pathology Laboratory of San Diego with the objective being to engender a compilation of histopathologic characteristics that allow the pathologist to identify the inciting materials. All cases of foreign body reactions located in the lips and perioral regions were reviewed by four pathologists, retaining those cases with a history of injection lip augmentation as well as those with histologic features previously documented to represent dermal filler substances. In selected cases, Alcian blue pH 2.5 with and without hyaluronidase pretreatment was performed. Immunohistochemical markers for macrophages (CD 68), adipocytes (S-100) and keratinocytes (AE1/AE2) were undertaken. All instances presented as single or multiple submucosal plaques, nodules or swellings. Natural polymers including collagen, hyaluronate, hydroxyapatite, poly-Llactate and synthetic polymers including carboxymethyl cellulose, dimethylpolysiloxane, and polyethyl methacrylate induce histologically unique features that allow for their identification. Host histopathologic responses included nodule without foreign body reaction, nodule with chronic inflammation, granuloma with epithelioid histiocytic and multinucleated giant cell reaction. Dermal filler foreign body host reactions in conjunction with the morphology of the foreign materials themselves are unique and can be differentiated from one another microscopically.

show abstract

Section: Discussionmentioning

confidence: 99%

Lip Augmentation Dermal Filler Reactions, Histopathologic Features

Eversole

Tran²,

Hansen³

et al. 2013

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Histologiquement, les formations nodulaires retrouvées après injection de Restylane® correspondraient soit à des réac-tions à corps étranger [3,5], soit à des réactions d'encapsulation inerte collagéniques, sans inflammation ni cellules géantes [15,29]. Dans le cas rapporté, l'AH était encapsulé dans une coque fibreuse non inflammatoire, sans cellules géantes.…”

Section: Discussionunclassified

“…Les seconds proviennent de substances naturelles comme le collagène (humain ou bovin) ou l'AH. Ils sont plus sûrs d'utilisation mais leur durée d'action est réduite du fait qu'ils sont résorbés par activité enzymatique [3,4].…”

unclassified

Complication après injection d’acide hyaluronique : présentation d’un cas

d’Elbée¹,

Fricain²

2013

Med Buccale Chir Buccale

View full text Add to dashboard Cite

Résumé -Les produits de comblement à base d'acide hyaluronique (AH) constituent une référence dans la correction et l'augmentation de volume des tissus mous faciaux. Ils ont une longue durée d'action, sont peu immunogènes et peuvent être éliminés par injection locale de hyaluronidase. Ces avantages expliquent leur utilisation fréquente. Des complications aiguës ou chroniques, mineures ou sévères, peuvent survenir après leur injection, même réalisée par un praticien expérimenté. Le cas d'une patiente ayant souffert de complications infectieuses et inflammatoires chroniques après injection d'acide hyaluronique est rapporté. Abstract -Complication following the injection of hyaluronic acid: a case report. Hyaluronic acid (HA) fillershave become the material of choice for soft-tissue augmentation of the face. They are longer lasting, less immunogenic and can be broken down by hyaluronidase. These advantages make HA fillers the most common of the temporary fillers on the market. However, early and delayed complications, ranging from minor to severe, can occur following HA-filler injection even if administered by an experienced practictioner. The case of a patient who suffered from chronic infectious and inflammatory complications following the injection of hyaluronic acid is reported.

show abstract

“…Collagen dermal fillers are available in the form of bovine collagen and human-based collagen [14,22].…”

Section: Discussionmentioning

confidence: 99%

“…However, a few cases of hypersensitivity and foreign body reaction have been documented, usually developing within 6-24 months [5][6][7][8][9][10][11][12][13][14][15]35].…”

Section: Discussionmentioning

confidence: 99%