Characterization of some commercial poly (styrene-divinylbenzene) copolymers for reversed-phase HPLC1

Stuurman, H. W.; Köhler, J.; Jansson, Sven-Olof; Litzén, A.

doi:10.1007/bf02316180

Cited by 34 publications

(7 citation statements)

References 17 publications

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“…The useful temperature range extends to 250 • C using ordinary binary solvent mixtures consisting of water and an organic co-solvent [12,13]. A variety of temperature stable columns based on metal oxides [14,15] or a polymeric material [16] are commercially available [17]. High-temperature HPLC (HT-HPLC) can be performed on every HPLC system.…”

Section: Introductionmentioning

confidence: 99%

Influence of the stationary phase on the stability of thalidomide and comparison of different methods for the quantification of thalidomide in tablets using high-temperature liquid chromatography

Giegold

Holzhauser

Kiffmeyer

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Influence of the stationary phase on the stability of thalidomide and comparison of different methods for the quantification of thalidomide in tablets using high-temperature liquid chromatography

Giegold

Holzhauser

Kiffmeyer

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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“…The main drawback of the polystyrene phases is their sensitivity to solvent changes connected with the presence of micropores in their internal structure [10,11]. The main drawback of the polystyrene phases is their sensitivity to solvent changes connected with the presence of micropores in their internal structure [10,11].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the porous structure of polymeric packings for HPLC

Gawdzik¹,

Osypiuk²

2001

Chromatographia

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Using inverse exclusion chromatography, the porous structure of four polymeric stationary phases has been investigated. Three of the copolymers were characterized by a high degree of crosslinking because they were synthesized from I',,vo tetrafunctional monomers. The fourth copolymerwas obtained from styrene (bifunctional monomer) and divinylbenzene (tetrafunctional monomer) and has a significantly smaller degree of crosshnking.To determine the pore size distribution of the copolymers, toluene, alkylphenones, phthalates, and polyslyrene standards were used as probes. Additionally changes of the volume of the copolymers when changing from water to tetrahydrofuran were determined. The results show that more stable porous structures were obtained from tetrafunctional monomers. All polymeric stationary phases have micropores in their internal structure but their contributions are different.

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“…Figure 2 shows the spectra of two pairs of the ST-DVB copolymers. For unmodified copolymers, absorption bands at 903, 990, 1630, 3021, and 3085cm ], which are typical for unreacted vinyl groups are visible [24,25]. The intensity of these bands decreases after modification.…”

Section: Porous Structurementioning

confidence: 95%

Modification of porous poly(styrene-divinylbenzene) beads by friedel-crafts reaction

Gadwdzik¹,

Osypiuk²

2001

Chromatographia

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SummaryThe influence of FrideI-Crafls reaction on the properties of poly(styrene-divinylbenzene) porous copolymers was studied. Two porous copolymers containing 0.7 and 0.9 mole fractions of divinylbenzene were used for modification. The aim of the process was to increase the copolymer crosshnking. As a crosslinker, tetrachloromethane in the presence of aluminium chloride was used. Reactions were monitored by FI-IR and XRF analyses.The main result of the modification process is the change of the copolymer porous structure. Modification also has an influence on the chromatographic properties of the copolymers, especially selectivities.

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Characterization of some commercial poly (styrene-divinylbenzene) copolymers for reversed-phase HPLC1

Cited by 34 publications

References 17 publications

Influence of the stationary phase on the stability of thalidomide and comparison of different methods for the quantification of thalidomide in tablets using high-temperature liquid chromatography

Influence of the stationary phase on the stability of thalidomide and comparison of different methods for the quantification of thalidomide in tablets using high-temperature liquid chromatography

Characterization of the porous structure of polymeric packings for HPLC

Modification of porous poly(styrene-divinylbenzene) beads by friedel-crafts reaction

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