Antibiotics, most notably sulfonamides and tetracyclines, are frequently used veterinary pharmaceuticals in animal husbandry. A new field of application for animal manure is in biogas plants for generating environmentally friendly energy. As a result, antibiotics contained in manure may still reach the environment as fermentation residues are also used on agricultural fields as fertilizers. Therefore, in fermentation tests seven sulfonamides and trimethoprim were investigated regarding their elimination behavior during a five-week fermentation process. Sulfadiazine, sulfamerazine, sulfamethoxazole, sulfadimethoxine, and trimethoprim were nearly completely eliminated while sulfathiazole, sulfamethazine, and sulfamethoxypyridazine showed persistence. For sulfadiazine it was possible by means of mass spectrometry to identify and partly quantify a metabolite, emerging from a hydroxylation at the pyrimidine ring, 4-OH-sulfadiazine. Furthermore, a microbial inhibition test showed a substantial reduction in the antimicrobial activity of the metabolite compared to the parent compound. Thus, the fermentation process may be an efficientwayto reduce the load of selected veterinary antibiotics finding their way into the environment Degradable drugs such as sulfadiazine may therefore, at least in the aspect of residual antibiotic activity of metabolites, be considered as environmentally friendly drugs.

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A large-scale study was carried out in order to determine the contamination level of antineoplastic drugs in pharmacies and to investigate the suitability and effects of wipe sample monitoring at regular intervals. A specific study design was developed. The 130 participating pharmacies were divided into a study and a control group, carrying out five and two wipe sampling cycles, respectively. The work practice was analyzed using questionnaires to identify factors that influence the contamination level. From 1269 wipe samples, 774 (61%) were contaminated with at least one of the analyzed cytotoxic drugs: cyclophosphamide, docetaxel, etoposide, 5-fluorouracil, gemcitabine, ifosfamide, methotrexate, and paclitaxel. A significant decrease of the contamination with cyclophosphamide and 5-fluorouracil was observed in the study group. The Monitoring-Effect Study of Wipe Sampling in Pharmacies method has proven to be a reliable and affordable tool for contamination control. Based on the 90th percentile of the contamination values, a substance-independent performance-based guidance value of 0.1ng cm(-2) has been derived.

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