Trace enrichment, chromatographic separation and biodegradation of cytostatic compounds in surface water

Kiffmeyer, Thekla K.; Götze, Hans‐Jürgen; Jursch, Martin; Lüders, Uwe

doi:10.1007/s002160050859

Cited by 86 publications

(60 citation statements)

References 3 publications

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“…No toxic effects were observed as toxicity control exceeded 25% ThOD and correlated well with calculated toxicity control. Kiffmeyer et al (1997), reported a biodegradation of 95% of MTX after seven days in an OECD confirmatory test. However MTX was classified as not readily biodegradable in a study performed with the 'manometric respiration test' OECD 301 F (Henschel et al, 1997) A decrease of the biochemical oxygen demand (BOD) was observed for the samples collected after the UV/H 2 O 2 treatment (photo-TPs generated after 256 min) after 28 days of the CBT (Fig.…”

Section: Biodegradationmentioning

confidence: 99%

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

et al. 2015

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Section: Biodegradationmentioning

confidence: 99%

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

et al. 2015

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“…A fraction of these drugs is metabolised before being excreted and future studies should focus on the screening of metabolites and transformation products (which could also be present in wastewaters) since most of these compounds can have equal or even greater activity than the parent compounds (2,71,72).…”

Section: Antineoplastic Drugs Impact On the Environmentmentioning

confidence: 99%

Forgotten public health impacts of cancer – an overview

Viegas

Ladeira

Veiga

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs). There are also hidden costs such as health insurance premiums and nonmedical expenses that are worth noting. This paper intends to present an overview of the generally forgotten impacts that the increasing number of cancer cases can have on the environment, workers who handle antineoplastic drugs, and health services. The knowledge available of each of the impacts will be addressed and discussed regarding the expected development. Overall, lessons learnt reflect on the impact of cancer through aspects not commonly evidenced in the literature or even considered in socio-economic analysis, in part due to the fact that these are difficult to contemplate in direct and indirect cancer costs already defined. Attention may be drawn to the need of continuous investment in prevention to reduce the negative impact on the environment, and in the health of workers who handle antineoplastic drugs for patients' treatment. KEY WORDS: costs of cancer; global burden; occupational healthGlobally, cancer is a growing public health problem. It is the second cause of death (21 %) after cardiovascular diseases (48 %), followed by respiratory diseases (12 %) in the sector of non-communicable diseases or diseases caused by non-infectious and non-transmissible medical conditions (1). Important resources are mobilised in order to improve research on new therapeutics, and ultimately devise a cure for this particular disease. Despite the increase in the effectiveness and specificity of chemotherapeutic treatments, cancer still remains one of the most harmful diseases (2-4).In 2012, worldwide incidence of cancer rose to an estimated 14 million new cases per year, with an estimated 8.2 million cancer deaths. The most common cancers diagnosed were of lung (1.8 million cases, 13 %), breast (1.7 million, 11.9 %) and colon (1.4 million, 9.7 %) (1

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“…Using adsorptive voltammetry, Kümmerer et al [30] determined the platinum concentration in hospital effluent ranging from 38 to176 ng/L, which was consistent with the annual consumption data. Kiffmeyer et al [6] estimated the biodegradability of cisplatinum using a standard 21 day The potential genotoxicity of cisplatin and carboplatin was evaluated by Ferk et al [31] they used Salmonella/microsome assay and single-cell gel electrophoresis with rat hepatocytes to assess the induction of DNA damage caused by platinum compounds in hospital sewage. The results revealed that cisplatin and carboplatin only caused significant DNA damage in the single-cell gel electrophoresis assay when the concentration is > 1 mg/L.…”

Section: Nonclassical Alkylating Agents (Platinum Compounds): Cisplatmentioning

confidence: 99%

“…Correspondingly, the predicted environmental concentration increased approximately one fold from 1.8 ng/L to 3.5 ng/L [5]. The total delivered amount of anticancer agents as pollutants comes from hospital sewage and municipal wastewater due to improper disposal by the patients [6]. A Swiss study using a mass flow analysis of cytostatic compounds demonstrated that only 1.1-3.7% of the excreted amount of these compounds was found in the hospital effluent [7].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Ecotoxicology, and Treatment of Anticancer Agents as Water Contaminants

Xie¹

2012

J Environ Anal Toxicol

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Trace enrichment, chromatographic separation and biodegradation of cytostatic compounds in surface water

Cited by 86 publications

References 3 publications

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

Forgotten public health impacts of cancer – an overview

Occurrence, Ecotoxicology, and Treatment of Anticancer Agents as Water Contaminants

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