Analysis of antibiotics in urine and wipe samples from environmental and biological monitoring—Comparison of HPLC with UV-, single MS- and tandem MS-detection

Tuerk, Jochen; Reinders, M.C.; Dreyer, Dennis; Kiffmeyer, Thekla K.; Schmidt, K. G.; Kuß, Heinz-Martin

doi:10.1016/j.jchromb.2005.11.030

Cited by 86 publications

(46 citation statements)

References 27 publications

(36 reference statements)

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“…Several techniques have been developed for determination of CAP in different biological materials. They are photoinduced chemiluminescence [4], high performance liquid chromatography (HPLC) with UV, single MS and tandem MS detection [5], capillary zone electrophoresis with amperometric detection [6], and surface plasmon resonance biosensor [7]. Although these methods have advantages of sensitivity and accuracy, their high cost and complicated operation limit their extensive application.…”

Section: Scheme 1 Chemical Structure Of Capmentioning

confidence: 99%

Fast Fourier transformation with continuous cyclic voltammetry at an Au microelectrode for the determination of morphine in a flow injection system

Norouzi

Ganjali

Moosavi-Movahedi

et al. 2007

Talanta

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Fast Fourier transformation with continuous cyclic voltammetry (FFTCV) in a flowing solution was applied as a detection system for the prompt Chloramphenicol (CAP) monitoring. In this method, the potential waveform consisted of two potential sections for cleaning of the electrode surface, accumulating CAP and potential ramp, which was continuously applied on a Pt-Au dual disk microelectrodes. The effects of various parameters on the sensitivity of the method were investigated. When the optimum conditions were imposed, this is a scan rate value of 70 V/s, an accumulation time of 500 ms, an accumulation potential of -300 mV and a pH value of 2. The method proved to be linear over the concentration range of 8.0 ×10 -9 -2.0 ×10 -5 mol/L (r = 0.9981) with a detection limit and a quantitation limit of 2.0 ×10 -9 and 6.6×10 -9 mol/L, respectively. Consequently, the method illustrates the requisite accuracy, sensitivity, precision and selectivity to assay CAP in its biological fluids. The proposed method has some advantages over other reported methods such as, no need for the removal of oxygen from the test solution, a sub-nanomolar detection limit, and finally the method is fast enough for the determination of any such compound, in a wide variety of chromatographic methods. As a result, FFTCV illustrates the benefits of precision, determination speed, cost-effectiveness, accuracy and simplicity, in comparison with formerly reported techniques.

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Section: Scheme 1 Chemical Structure Of Capmentioning

confidence: 99%

Fast Fourier transformation with continuous cyclic voltammetry at an Au microelectrode for the determination of morphine in a flow injection system

Norouzi

Ganjali

Moosavi-Movahedi

et al. 2007

Talanta

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“…It is endorsed in the British pharmacopeia (BP; British pharmacopeia, 2007), United State Pharmacopoeia (USP; United State Pharmacopoeia, 2005), and the European Pharmacopoeia (EuPh;European Pharmacopoeia, 2005). According to literature surveys, there are various analytical methods for estimating OFL alone and in combination, such as by spectrophotometric and atomic absorption spectroscopy (Shivkumar, Gunturu, & Indrakanti 2011;Rege, Sathe, Salvi, & Shotri, 2011;Bhusari & Chaple, 2009;Abdulgader, Ebraheem, & Elbashir,, 2012;Vinay, Revanasiddappa, Divya, & Rajendraprasad, 2009;Hesham 2005), potentiometric and conductometric (Tuncel & Atkosar 1992), high performance liquid chromatography (High Performance Liquide Chromatography; Attimarad 2010; Miniyar et al, 2012;Shinde, Bhoir, Pawar, Yadav, & Bhagwat,, 2010;Khandagle, Gandhi, Deshpande, & Gaikwad, 2011;Kotaiah, Shaikh, Rao, Venkateswarlu, & Konda, 2011;Narayana, Manohara, & Appala, 2006), and liquid chromatography tandem-mass spectrometry Leea, Pearta, & Svobodab, 2007;Tuerk et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Rp-HPLC Method for Simultaneous Determination of Metronidazole and Ofloxacin in Synthetic Mixture

Maslarska

Tsvetkova

Peikova

et al. 2016

CBUP

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Development and validation of a high-performance liquid chromatographic analytical procedure for simultaneously determining metronidazole and ofloxacin in a synthetic mixture is described in this paper. The separation was made with a LiChrosorb ® RP-18 (250 × 4.6 mm) column, at 30 °C temperature, with isocratic mode and mobile phase, containing triethylamine, acetonitrile, and 0.3% o-phosphoric acid solution (0.02:20:80 v/v/v). Eluent was monitored at 290 nm and the flow rate was 1.0 ml/min. Metronidazole and ofloxacin were effectively separated with retention time (t r ) of 3.42 min and 6.15 min, respectively, within the selected chromatographic conditions. The method was validated for analytical parameters: specificity, linearity, precision, accuracy, and limits of detection and quantitation. The calibration curves were linear in the concentration range of 12.5 to 100.0 µg/ml for metronidazole and ofloxacin, and the regression coefficients were more than 0.999. For metronidazole and ofloxacin the recovery was 100.01% and 100.04%, respectively. This analytical procedure is applicable for the quality control of drug formulations. UDC Classification: 543.6, DOI: http://dx

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“…A literature search indicates that HPLC has been used to analyze cefazolin sodium alone 26 and in combination with other drugs often coadministered. 27,28 However, there have been few stability studies of cefazolin sodium using HPLC.…”

Section: Introductionmentioning

confidence: 99%

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

Hasan¹,

Sher²,

Siddiqui³

et al. 2013

RRMC

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This paper reports a validated high-performance liquid chromatography method which is rapid, highly specific, and accurate for determination of cefazolin sodium in injectable pharmaceutical formulations. Separation was carried out using a Hibar ® µBondapak ® C 18 column with a mobile phase consisting of an acetonitrile to monobasic sodium phosphate buffer ratio of 17:83 and a flow rate of 1.0 mL per minute, and monitoring at a wavelength of 254 nm. The calibration curve was linear, with a correlation coefficient .0.9995 in the range of 5-100 µg/mL. Drug recovery was 98.35%-100.86%, with a limit of detection of 12.92 ng/mL and a limit of quantification of 43.09 ng/mL. The drug was subjected to stress conditions of hydrolysis (acid, base, oxidation, and thermal degradation), where maximum degradation was observed. Forced degradation studies confirmed stability indicating power of this method, which was validated in accordance with International Conference on Harmonization guidelines and used successfully to quantify the amounts of cefazolin sodium in bulk injectable formulations and in physiological fluid.

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Analysis of antibiotics in urine and wipe samples from environmental and biological monitoring—Comparison of HPLC with UV-, single MS- and tandem MS-detection

Cited by 86 publications

References 27 publications

Fast Fourier transformation with continuous cyclic voltammetry at an Au microelectrode for the determination of morphine in a flow injection system

Fast Fourier transformation with continuous cyclic voltammetry at an Au microelectrode for the determination of morphine in a flow injection system

Rp-HPLC Method for Simultaneous Determination of Metronidazole and Ofloxacin in Synthetic Mixture

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

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