Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Abstract

Hypertension, hyperlipidemia, and diabetes are important precursors of cardiovascular disease. Here, we evaluated the antihypertensive, antihyperlipidemic, and antidiabetic potential of five types of sprouts in fructose-loaded spontaneously hypertensive rats (SHRs). Powdered sprouts (PSs) were produced from mung bean, broccoli, radish, and buckwheat sprouts and germinated soybeans by lyophilization. The PSs were analyzed for nutritional composition and bioactive agents (γ-aminobutyric acid [GABA], coenzyme Q10 [CoQ10], rutin, and myo-inositol-1,2,3,4,5,6-hexakisphosphate [IP6]) and functionally tested in SHRs given water containing 25 % fructose and diets containing 30 % PS for 46 days. All PSs were nutritionally rich in protein and dietary fiber. CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively. Mung bean, broccoli, and buckwheat PSs caused significant reductions in heart rates and/or serum triglycerides. Mung bean PS also significantly reduced serum total cholesterol. These data supported the antihypertensive and antihyperlipidemic potential of mung bean, broccoli, and buckwheat sprouts.

A review on nutritional composition, antinutritional components and health benefits of green gram ( Vigna radiata (L.) Wilczek )

“…strain 5,351 have improved its antihyperglycemic effects by reducing blood glucose levels, cholesterol, and triglyceride low‐density lipoproteins and improving the level of insulin secretion in alloxan‐induced hyperglycemic mice (Yeap et al., 2012). Powdered green gram sprout extracts showed similar levels of glucose and insulin as compared to control in fructose loaded spontaneously hypertensive rats (Nakamura et al., 2016). The methanolic plant extract of green gram reduced blood glucose levels by 168.66 mg/dl, triglyceride by 72.33 mg/dl, and cholesterol by 154 mg/dl in alloxan monohydrate induced diabetic rabbits (Bilqees et al, 2020).…”

Influence of Plasma Treatment on the Polyphenols of Food Products—A Review

“…Sprouts are also sources of bioactive compounds such as polyphenols, γ-aminobutyric acid, and isothiocyanates [53]. Moreover, the bioactive compounds found in broccoli sprouts have antihyperlipidemic and antihypertensive potentials [55]. Sprouts are usually consumed fresh or in minimally processed salads or side dishes, especially among health-conscious consumers [56].…”

Radish (Raphanus sativus) and Diabetes

“…In addition, radish was found to contain coenzyme Q10 (also named ubiquinone), a fat-soluble antioxidant coenzyme and a component of the electron transport chain in human mitochondria, which prevents the development of type 2 diabetes [ 39 , 40 , 41 , 42 ]. The in vivo system study published by Lee et al (2014) suggested that coenzyme Q10 at ~1600–2000 mg kg −1 of body weight in mice weighing 25–30 g, which equals ~130.1–162.6 mg/kg of body weight in humans, could be a promising therapeutic approach for ameliorating oxidative stress in glaucomatous neurodegeneration [ 43 ].…”