Characterization, antioxidant, antimicrobial and cytotoxic activities of green synthesized silver and iron nanoparticles using alcoholic Blumea eriantha DC plant extract

Chavan, Rohankumar R.; Bhinge, Somnath D.; Bhutkar, Mangesh A.; Randive, Dheeraj S.; Wadkar, Ganesh H.; Todkar, Sachin S.; Urade, Mukund N.

doi:10.1016/j.mtcomm.2020.101320

Cited by 52 publications

(35 citation statements)

References 46 publications

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“…Nanoparticles have proved to be effective carriers for a variety of materials such as phytoconstituents, drug moieties, and functional dietary ingredients [31]. Conventional therapies used in cancer treatment suffer from several disadvantages and therefore there is an urgent need to explore the phytomedicine(s) which are effective and devoid of side effect(s).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, effectiveness of the traditional medicine can be further modified if they are presented in nano form. Also, the targeting efficacy of the nanoparticles is markedly increased and drug release may be achieved at the desired site in an effective manner [31]. Conventional anticancer therapies in the treatment of colorectal cancer often exhibits discouraging results owing to the fact that the drug release occurs in the stomach and/or the intestinal region and inadequate amount of drug reaches to the colonic site.…”

Section: Resultsmentioning

confidence: 99%

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Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell

Shejawal¹,

Randive²,

Bhinge³

et al. 2021

J Mater Sci: Mater Med

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Our study aimed at development of Silver, Iron and Gold nanoparticles of Lycopene isolated from tomato by using green synthesis technique and to evaluate its anticancer potential against colorectal and cervical cancer. Lycopene was extracted by benzene extraction method and the silver, iron and gold nanoparticles were developed by green synthesis method. 1% aqueous extract of isolated Lycopene was mixed with 1% solutions of AgNO3, FeCl3 and HAuCl4 solutions and incubated at ambient temperature for 3–4 h separately and observed for the color change which is an indicative of formation of the nanoparticles. The prepared nanoparticles were characterized by FTIR, SEM, XRD analysis and evaluated for their antimicrobial potential. The cytotoxicity studies were carried out by in vitro assay like MTT, SRB and Tryphan blue method against Colo 320 DM, HT 29, and Hella. SEM showed nanosized particles of 50–100 nm range, whereas no antimicrobial activity was exhibited by the prepared nanoparticles. In MTT assay the LyAgNP showed maximum 41.41 ± 0.4124% inhibition against COLO320DM, whereas LyGNP exhibited 41.47 ± 0.4469% inhibition against HT 29 and LyAgNP showed 40.9 ± 0.6908% inhibition against Hella cells. In SRB assay LyAgNP showed maximum 82.68 ± 1.1798% inhibition against COLO320DM, whereas LyGNP exhibited maximum 91.21 ± 0.2372% inhibition against HT29 and 87.98 ± 0.5878% inhibition against Hella cells. In tryphan blue assay against COLO320DM, HT29 and Hella cells, the maximum inhibition exhibited by the prepared nanoparticles were observed as LyGNP 83.45 ± 0.4694%, LyAgNP 88.05 ± 0.1870% and LyAgNP65.47 ± 0.4766%. We conclude that the developed nanoparticles of Lycopene exhibited potential anticancer activity against Colorectal and cervical cancer cell as compared with pure Lycopene.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell

Shejawal¹,

Randive²,

Bhinge³

et al. 2021

J Mater Sci: Mater Med

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“…Nanotechnology can be termed as the exploitation of matter through specific chemical and/or physical processes to produce materials with specific properties, which can be utilized in particular applications [ 4 , 5 ]. A nanoparticle can be a microscopic particle or material that has at least one dimension less than 100 nm in size [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver and iron nanoparticles of isolated proanthocyanidin: its characterization, antioxidant, antimicrobial, and cytotoxic activities against COLO320DM and HT29

Shejawal¹,

Randive²,

Bhinge³

et al. 2020

Journal of Genetic Engineering and Biotechnology

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Background In the current research, we have developed silver and iron nanoparticles of isolated proanthocynidin (PAC) from grape seed by green synthesis and evaluated for antimicrobial, antioxidant activity and in vitro cytotoxicity against colon cancer cell lines. Results One percent solution of isolated proanthocynidin in water was vigorously mixed with 1% silver nitrate and 1% ferric chloride solution and kept for 4 h, to yield PACAgNP and PACFeNP. The synthesized nanoparticles were characterized by UV, FTIR, XRD, and SEM analysis and evaluated for antimicrobial potential against selected microbes. Moreover, the synthesized nanoparticles were studied for DPPH assay and in vitro cytotoxicity using colon cancer cell lines COLO320DM and HT29 (MTT, SRB, and Trypan blue assay). UV spectroscopy confirmed the development of nanoparticles. SEM analysis showed that the particles were aggregated in the size range of 50 to 100 nm. Antimicrobial potential was found to be less against Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli , whereas cytotoxicity of PACAgNP and PACFeNP against COLO320DM and HT29 exhibited promising results as compared to the pure PAC. PACAgNP and PACFeNP exhibited 20.83 ± 0.33% and 18.06 ± 0.60% inhibition, respectively, against DPPH radical, whereas pure PAC showed 16.79 ± 0.32% inhibition and standard (ascorbic acid) exhibited 98.73 ± 0.18% inhibition of DPPH radical. Conclusion The silver and iron nanoparticles were successfully developed by green synthesis method using isolated proanthocynidin which is economical and eco-friendly. The use of metal nanoparticles may open up a new opportunity for anticancer therapies to minimize the toxic effects of available anticancer drugs specifically in targeting specific site. Graphical abstract

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“…Blumea eriantha DC plant extract possesses polyphenolic groups as a source of reducing and capping agent for synthesis of BEAgNPs and BEFeNPs 53 . We hypothesized that B eriantha DC crude extract could be used for the green synthesis of silver (Ag + to Ag 0 ) and iron (Fe 3+ to Fe 0 /Fe 3 O 4 ) NPs.…”

Section: Discussionmentioning

confidence: 99%

In vivo and in vitro hair growth‐promoting effect of silver and iron nanoparticles synthesized via Blumea eriantha DC plant extract

Chavan¹,

Bhinge²,

Bhutkar³

et al. 2020

J of Cosmetic Dermatology

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Background Blumea eriantha DC is the Indian medicinal remedy, mainly distributed in the States of India. It possesses wide array of medicinal properties. Aim To execute green synthesis approach for the preparation of silver and iron nanoparticles by using alcoholic Blumea ErianthaDC extract and to verify the biological potential of the prepared nanoparticles as a hair growth promoter. Patients/Method Extract was mixed with silver nitrate and ferric chloride for synthesis of silver and iron nanoparticles, respectively. Prepared nanoparticles were confirmed by UV, FT‐IR, SEM, X‐ray diffraction, and TEM. The qualitative and quantitative analysis was performed namely hair growth initiation, hair growth completion, hair length, hair weight, histopathological studies, skin thickness, and length of the hair follicle. Results The prepared nanoparticles were observed as a blend of spherical and irregular shape with an average particle size of 35nm. The transition of anagen hair follicles was observed in approximately 63.43 % of animals treated with Minoxidil, whereas 2% and 5% Blumea erianthasilver nanoparticles treated animal group exhibited 33.02% and 60.93%, respectively. The animal groups treated with 2% and 5% iron nanoparticles of Blumea Eriantha showed 44.09 and 38.89% in anagen induction, respectively, which suggest the hair growth‐promoting potential of the extract of Blumea erianthaDC. Conclusion Thus, it can be concluded that silver nanoparticles of Blumea Eriantha exhibit promising hair growth promoting activity.

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Characterization, antioxidant, antimicrobial and cytotoxic activities of green synthesized silver and iron nanoparticles using alcoholic Blumea eriantha DC plant extract

Cited by 52 publications

References 46 publications

Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell

Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell

Green synthesis of silver and iron nanoparticles of isolated proanthocyanidin: its characterization, antioxidant, antimicrobial, and cytotoxic activities against COLO320DM and HT29

In vivo and in vitro hair growth‐promoting effect of silver and iron nanoparticles synthesized via Blumea eriantha DC plant extract

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