Characterization and screening of anticancer properties of cerium oxide nanoparticles synthesized using <i>Averrhoa carambola</i> plant extract

Ganeshkar, Madhu Prakash; Goder, Premakshi Hucharayappa; Mirjankar, Manisha R.; Gaddigal, Anjana Thatesh; Shivappa, Parashuram; Kamanavalli, Chandrappa M.

doi:10.1080/24701556.2022.2077374

Cited by 5 publications

(1 citation statement)

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“…The studies of Yulizar et al, (21) showed that CeO 2 NPs synthesized by Datura metel L. leaf extract exhibited considerable free radical scavenging activity (16.61%). Whereas, green synthesized CeO 2 NPs from different plant extract reported the highest antioxidant activity at 500µg/mL (22,23) . Therefore, the present study aimed to biosynthesize CeO 2 NPs, using B. monnieri leaf extract as a reducing agent, and to evaluate its antioxidant activity.…”

Section: Introductionmentioning

confidence: 97%

Green synthesis of Ceriumoxide Nanoparticles using Bacopa monnieri Leaf Extract - In vitro A ntioxidant Activity

Gopinath¹,

Sultana²,

Punekar³

et al. 2023

IJST

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Objectives: Cerium oxide nanoparticles were synthesized by a rapid green method using an aqueous leaf extract of Bacopa monnieri to investigate its antioxidant activity. Methods: Cerium oxide nanoparticles (CeO 2 NPs) were synthesized using Bacopa monnieri leaf extract as a stabilizing agent by solution combustion method. Characterization techniques like FTIR, PXRD,SEM-EDAX, HR-TEM, UV-visible, and Raman spectroscopy confirmed the synthesized NPs. The antioxidant capacity was assessed by in vitro Hydroxyl radical scavenging assay. Findings: The biosynthesized CeO 2 NPs possess tiny spherical shapes and sizes ranging from 5-50nm, and the average particle size is 27 nm as measured by HR-TEM. XRD and Raman confirm the nanoparticle's polycrystalline nature and face-centered cubic fluorite structure with maximum UV-visible absorbance at λ max 301.2nm. The biosynthesized CeO 2 NPs exhibited better scavenging activity than Vitamin C. However, further in vitro and in vivo studies must be warranted to explore its mechanism and therapeutic potential. Novelty: To the best of our knowledge, this is the first report involving the green synthesis of cerium oxide nanoparticles using Bacopa monnieri leaf extract, which exhibited potent hydroxyl radical scavenging activity which can be a promising therapeutic candidate in oxidative stress-related disorders.

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Section: Introductionmentioning

confidence: 97%