Characteristic differences in barrier and hygroscopic properties between normal and cosmetic dry skin. I. Enhanced barrier analysis with sequential tape‐stripping

Lu, Nanshu; Chandar, P.; Tempesta, Daniel; Vincent, Christian; Bajor, John; McGuiness, H.

doi:10.1111/ics.12112

Cited by 20 publications

(31 citation statements)

References 38 publications

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“…Xerotic skin has a lower SC water content and often shows proper barrier function, even if it is only reflected by the TEWL [58] . The conclusion can be made that static TEWL measurements are not sufficient to evaluate effects on EPB with subnormal baseline values (<5 g/m 2 /h) in the elderly.…”

Section: Discussionmentioning

confidence: 99%

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

Blaak¹,

Kaup²,

Hoppe³

et al. 2015

Skin Pharmacol Physiol

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Background: The pH of the stratum corneum (SC) in the elderly is elevated and linked to impaired SC function. Therefore, this paper addresses the question of whether acidic skin care generates positive clinical, biophysical, and microbiological effects in aged skin. Methods: This study was performed to assess skin care effects in nursing home residents (aged 80-97 years). Visual, biophysical, and microbiological methods were used. Subjects were randomly assigned to 1 of 2 groups and treated over 7 weeks with skin care products adjusted to a pH of 4.0 (group A) or a pH of 6.0 (group B). Results: Compared to baseline, SC integrity improved significantly in group A (p = 0.007), whereas there was no change in group B (p = 0.672). SC recovery 24 h after perturbation increased significantly in group A (p = 0.004) compared to baseline. The SC recovery in group B was not significant compared to baseline (p = 0.327). Conclusion: Long-term treatment with pH 4.0 skin care results in a significant improvement in epidermal barrier function compared to identical products with a pH of 6.0. In addition, effects on skin dryness and resident flora were demonstrated, but without significant differences, between the 2 groups. Based on these results, we recommend adjustment of skin care products for the elderly to a pH of 4.0 to maintain the health of aged skin.

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Section: Discussionmentioning

confidence: 99%

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

Blaak¹,

Kaup²,

Hoppe³

et al. 2015

Skin Pharmacol Physiol

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“…This non‐uniform SC removal by consecutive tape stripping was evident for both body sites investigated. Our findings are in line with previous studies which observed non‐uniform SC recovery from sequential tape stripping . In addition, increased skin hydration probably contributes to the decreased adhesiveness to the tapes in deeper layers of SC.…”

Section: Discussionmentioning

confidence: 99%

Variation in stratum corneum protein content as a function of anatomical site and ethnic group

Raj

Voegeli

Rawlings

et al. 2015

Intern J of Cosmetic Sci

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Facial SC is morphologically distinct from the forearm, as demonstrated by the differences in amounts of SC removed. Although the data distribution in different subject groups varied, the regression was always quite similar between the two body sites and both ethnic groups. Also, the correlations were similar to previously published data on other body sites. The resultant calibration curves can be used as a rapid indirect protein assessment of tape strippings from the cheek.

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“…It protects the underlying tissue from water loss, chemicals, infection and mechanical stress . Transepidermal water loss (TEWL) is commonly used to measure SC barrier function in the clinical setting; however, TEWL measurements alone provide only an apparent measure of barrier quality (ie, the skin's overall resistance to passive water diffusion through the skin) …”

Section: Introductionmentioning

confidence: 99%

“…Recently, Lu and colleagues developed a novel clinical and data analysis procedure based on sequential tape stripping with TEWL measurement and SC protein analysis, in the course of a study investigating the SC barrier and the hygroscopic properties of normal and cosmetic dry skin. This procedure was thought to be a more robust method than those previously used for SC barrier analysis …”

Section: Introductionmentioning

confidence: 99%

Exploratory study to evaluate two clinical methods for assessing moisturizing effect on skin barrier repair

Snatchfold

Targett

2019

Skin Research and Technology

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BackgroundTwo clinical methods of assessing a moisturizer's effect on stratum corneum (SC) barrier repair were evaluated in female subjects with dry skin, to identify an assessment method for future studies.MethodsIn this single‐centre, split‐body study, women with dry skin applied moisturizer before (method A) or after (method B) SC barrier perturbation using D‐Squame® stripping discs. Transepidermal water loss (TEWL) and residual protein on D‐Squame discs were assessed over 14 days.ResultsTwenty‐four subjects were included. For method A, the mean slope values of plots of 1/TEWL vs cumulative protein removed decreased over time for both treated and untreated areas, indicating improved SC barrier quality. There were no significant differences between treated and untreated areas, although a trend to a more negative slope was observed by Day 14 in the treated areas (P = 0.082), suggesting treatment improved barrier quality. For method B, using pre‐ and post‐stripping as covariates, no statistical differences/trends were observed between treated and untreated areas for change in TEWL from post‐stripping to any evaluation from Days 3‐14. TEWL values returned towards pre‐stripping values for treated and untreated areas by the initial Day 3 evaluation.ConclusionFor method A, there were trends suggesting the moisturizing treatment improved SC barrier quality. For method B, there were no significant differences/trends between treated and untreated areas. Further assessment with different methodologies is warranted to design appropriate clinical protocols for evaluating accelerated skin barrier repair. These data are insufficient to conclude whether the product or methodology was responsible for the results.

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Characteristic differences in barrier and hygroscopic properties between normal and cosmetic dry skin. I. Enhanced barrier analysis with sequential tape‐stripping

Cited by 20 publications

References 38 publications

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

Variation in stratum corneum protein content as a function of anatomical site and ethnic group

Exploratory study to evaluate two clinical methods for assessing moisturizing effect on skin barrier repair

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