Changes of Serum Retinol Binding Protein 4 Levels Following 8 Weeks Moderate Aerobic Exercise

Abstract

Purpose: The purpose of this study was to examine the effects of 8 weeks moderate intensity aerobic exercise on serum retinol binding protein 4 (RBP4) levels in female athletes.Methods: Twenty female karate athletics were randomly assigned to one of the exercise group (n=10) or control group (n=10). The training group performed endurance training 3 days a week for 8 weeks at an intensity corresponding to 50-60% individual maximum oxygen consumption for 45 min.Results: Body mass and body mass index increased (P<0.05) after 8 weeks aerobic exercise compared to the control group. For waist to hip ratio (WHR), body fat percentage and maximal oxygen consumption there were no significant differences between the exercise group and the control group. There were virtually no changes in body fat percentage, fasting glucose, insulin, insulin resistance and RBP4 levels after 8 weeks training.Conclusion: Serum RBP4 level was not affected by 8-week moderate aerobic exercise in female athletes.

The Effect of Eight Weeks of Combined Exercise on Retinol Binding Protein 4, Fatty Acid Binding Protein and Lipocalin-2 in Type 2 Diabetic Women (Clinical Trial)

“…Some studies have proposed FABP changes after exercise stemmed from changes in fat mass and body fat percent-age following exercise (29). Contrary to the findings of this study, there was no significant effect on the serum level of RBP-4 in athletes after eight weeks of training in a previous study (30). It seems that lower RBP-4 concentrations in athletes compared to diabetics patients and those with impaired glucose tolerance can be a reason for insignificant effect of training (30).…”

“…Contrary to the findings of this study, there was no significant effect on the serum level of RBP-4 in athletes after eight weeks of training in a previous study (30). It seems that lower RBP-4 concentrations in athletes compared to diabetics patients and those with impaired glucose tolerance can be a reason for insignificant effect of training (30). This discrepancy in results could be attributed to the type and intensity of the training, sampling time after the last training session and the physical condition of the subjects.…”

The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats

“…Moreover, running on treadmill resulted in a reduction in protein and gene expression of RBP4 in serum [ 18, 19 ] and visceral and subcutaneous fat tissue in diabetic [ 2 ] and spontaneously hypertensive [ 18, 19 ] rats. In contrast, in other studies, it has been reported that neither moderate to intensive aerobic exercise [ 4 , 6 , 17 ] nor walking exercise [ 16 ] had any significant effect on fasting glucose, insulin, resistance insulin, and circulating levels of RBP4 in females with type 2 diabetes [ 16, 17 ] and healthy athletes [ 4, 6 ].…”

“…There is now a substantial body of evidence to suggest that destruction of beta cell, decreased levels of insulin and its receptors, and decreased content of glucose transporters (GLUTs) resulted in insulin resistance [ 1–3 ]. Current evidence has reported that retinol-binding protein 4 (RBP4) is also one of the mechanisms involved in the incidents of diabetes [ 2 , 4–6 ].…”

“…RBP4 is a newly discovered fat-derived adipokine [ 2 ] that belongs to the lipocalin family [ 5 ] and is encoded by the RBP4 gene [ 6 ]. RBP4 specifically binds to retinol [ 7 ] and transthyretin [ 4 ] in blood stream [ 8 ]. Its single known function is to deliver vitamin A to tissues via the blood [ 9 ].…”