The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats

Yousefi, Mohammad; TaheriChadorneshin, Hossein

doi:10.1556/1646.9.2017.34

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…Additionally, the results of this study showed up regulation of RBP4 expression in HFD rats. From previous hypothesis RBP4 elevates gluconeogenesis in the liver, so hyperglycemia is occurring (Hutchison, Harrison, Stepto, Meyer, & Teede, ), hinders the insulin signaling in muscle and decreases the uptake of glucose by reduction the action of PI3K (Yousefi & TaheriChadorneshin, ). Defects in PI3K reported in other findings (Jiang & Zhang, ).…”

Section: Discussionmentioning

confidence: 92%

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

et al. 2019

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The liver is the main organ involved in lipid metabolism process and it helps in drug detoxification. Insulin resistance is considered one of risk reasons which lead to several metabolic diseases. Currently, berberine (BER) occupies a huge challenge against multiple diseases with no toxic effect. The present work was aimed to identify, does BER-chloride has a poisonous influence on the liver? and investigating the outcome of BER-chloride on PI3K/Akt-p/SIRT-1/PTEN pathway during insulin resistance syndrome. The insulin resistance model was achieved in experimental female rats via high-fat diet (HFD). Glucose, insulin, lipid profiles, and hepatic oxidative stress parameters were assessed. PI3K, AKt-p, SIRT-1, and PTEN levels in hepatic tissue were determined at genome and protein levels. Further adiponectin concentration was performed in serum, hepatic, and white adipose tissues. Molecular study of fold alteration in insulin, insulin receptor, and retinol binding protein-4 (RBP4) in liver was done. Practical applicationsObesity syndrome causes multiple obstacles in modern years. The current results revealed elevation the body weight of rats, plasma glucose, homeostatic model assessment, glycated hemoglobin, insulin, and lipid profiles concentrations in a group of rats, which nourished HFD for 8 weeks and this rise, was diminished after 2 weeks from BER-chloride administration. Further, BER-chloride improved transaminases enzymes, pro-oxidant, and antioxidant defense system, PI3K, AKt-p, SIRT-1, and PTEN in the liver, with downregulation of hepatic RBP4. Hence, these data provide a crucial message that BER-chloride enhanced both hepatic function and insulin signaling pathways that might be of therapeutic importance to insulin resistance with no harmful effect on the liver. BER-chloride is predicted to be a drug of choice for obesity complications cure. K E Y W O R D Sberberine chloride, hepatotoxicity, insulin receptor, liver

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Section: Discussionmentioning

confidence: 92%

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

et al. 2019

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“…Additionally, results of current study showed up regulation of RBP4 expression in HFD rats. From previous studies RBP4 i: elevates the process of gluconeogenesis in liver so hyperglycemia is occurred [29], ii: hindered the insulin signaling in muscle and iii: decreased the uptake of glucose by reduction the activity of PI3K [30]. Defects in PI3K demonstrated in other findings [31].…”

Section: Discussionmentioning

confidence: 93%

Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome-induced rats

El‐Zeftawy

Ghareeb

2018

Preprint

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19Insulin resistance is one of dangerous factors as it leads to numerous metabolic 20 disorders such as non-insulin dependent diabetes mellitus. It affects most tissues 21 mainly adipose tissue, liver and muscle. Nowadays, berberine has several medical 22 applications against diseases. The current study was carried out to identify the effect 23 of berberine chloride (BER-chloride) on phosphatidyl inositol-3-kinase/ 24 phosphorylated protein kinase B/ sirtuin type 1/ phosphatase and tension homologue 25 (PI3K/Akt-p/SIRT-1/PTEN) pathway during insulin resistance phenomena. Insulin 26 resistance model was performed in experimental rats by using high fat diet. Plasma 27 glucose, serum insulin, lipid profiles, hepatic oxidative stress markers were estimated. 28 Serum transaminases activities and kidney function tests were determined. Further, 29 hepatic PI3K, AKt-p, SIRT-1; PTEN levels were assayed. The concentration of 30 adiponectin in serum, hepatic tissue and white adipose tissue was determined. 31 Moreover, fold change in hepatic insulin, insulin receptor and retinol binding protein-32 4 (RBP4) at molecular level was performed. Histopathological study of white adipose 33 tissue was also determined. The results showed increase the rats' body weights, blood 34 glucose, homeostatic model assessment, glycated hemoglobin, insulin and lipid 35 profiles levels in group of rats fed on high fat diet for eight weeks and this elevation 36 was decreased after administration of BER-chloride for two weeks. Further, BER-37 chloride administration exhibited improvement of oxidative stress parameters, PI3K, 38 AKt-p, SIRT-1 and PTEN. This was associated with down-regulation of RBP4.39According to these data we conclude that, BER-chloride mediated several insulin 40 signaling pathways that could be of therapeutic significance to insulin resistance. 41

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“…Moreover, RBP4 serves a key role in IR-mediated activation of the JAK2/STAT5 signaling pathway ( 42 , 51 ). RBP4 also participates in development of hyperglycemia in muscle via inhibition of PI3K activity ( 19 , 33 , 54 , 55 ) and in liver via increased PEPCK activity ( 33 , 42 ). It also regulates OS via mitochondrial dysfunction ( 72 , 73 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the skeletal muscle of Wistar rats, RBP4 levels decrease insulin-dependent glucose uptake ( 54 ). RBP4 is associated with impaired insulin signaling, decreased affinity of insulin receptor substrate (IRS) 1 for PI3K and decreased GLUT4 translocation to the cell membrane, which decreases glucose uptake and increases IR in the muscle ( Fig.…”

Section: Rbp4 In Irmentioning

confidence: 99%

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)

et al. 2022

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Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders. Retinol-binding protein 4 (RBP4) is an adipokine that transports vitamin A or retinol in the blood. High levels of RBP4 are associated with development of metabolic disease, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2D). The present review summarizes the role of RBP4 in obesity and associated chronic alterations. Excessive synthesis of RBP4 contributes to inflammatory characteristic of obesity by activation of immune cells and release of proinflammatory cytokines, such as TNFα and ILs, via the Toll-like receptor/JNK pathway. The retinol-RBP4 complex inhibits insulin signaling directly in adipocytes by activating Janus kinase 2 (JAK2)/STAT5/suppressor of cytokine signaling 3 signaling. This mechanism is retinol-dependent and requires vitamin A receptor stimulation by retinoic acid 6 (STRA6). In muscle, RBP4 is associated with increased serine 307 phosphorylation of insulin receptor substrate-1, which decreases its affinity to PI3K and promotes IR. In the liver, RBP4 increases hepatic expression of phosphoenolpyruvate carboxykinase, which increases production of glucose. Elevated serum RBP4 levels are associated with β-cell dysfunction in T2D via the STRA6/JAK2/STAT1/insulin gene enhancer protein 1 pathway. By contrast, RBP4 induces endothelial inflammation via the NF-κB/nicotinamide adenine dinucleotide phosphate oxidase pathway independently of retinol and STRA6, which stimulates expression of proinflammatory molecules, such as vascular cell adhesion molecule 1, E-selectin, intercellular adhesion molecule 1, monocyte chemoattractant protein 1 and TNFα. RBP4 promotes oxidative stress by decreasing endothelial mitochondrial function; overall, it may serve as a useful biomarker in the diagnosis of obesity and prognosis of associated disease, as well as a potential therapeutic target for treatment of these diseases.

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The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats

Cited by 5 publications

References 20 publications

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome-induced rats

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)

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