Changes in Serum Levels of Type I Collagen-Related Proteins after Surgically Induced Menopause and Correlations with Bone Loss in the Lumbar Spine.

Yasumizu, Takehiko; Fukada, Yukihito; Hoshi, Kazuhiko

doi:10.1507/endocrj.46.337

Cited by 8 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This means that bone resorption is a main determinant of bone loss in the postmenopausal period. We obtained similar results in previous prospective studies in population of healthy postmenopausal women on hormone replacement therapy [3] and of women in surgicallyinduced postmenopausal state [5]. In addition, to the best of our knowledge, this is the first report that presents the age-related changes in serum ICTP in postmenopausal women.…”

Section: Discussionsupporting

confidence: 86%

“…In a previous series of studies, we assessed the changes in the bone metabolism in various populations of Japanese women using three serum biochemical markers, a marker for bone resorption, the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), and two markers for bone formation, the carboxyterminal propeptide of type I procollagen (PICP) and bone gla protein (BGP), and confirmed their performances as indices of bone turnover [3][4][5].…”

mentioning

confidence: 75%

“…Especially the change of serum ICTP is strongly correlated with the changes in bone density in postmenopausal women under hormone replacement treatment [3], as well as in women after surgicallyinduced menopause [5].…”

mentioning

confidence: 98%

See 2 more Smart Citations

Age-Related Changes in Bone Mineral Density and Serum Bone-Related Proteins in Premenopausal and Postmenopausal Japanese Women.

et al. 2000

Self Cite

View full text Add to dashboard Cite

Abstract.The purpose of this cross-sectional study was to characterize the age-related change in bone metabolism during the pre-and postmenopausal periods, and to define the standard levels of three serum markers of bone metabolism, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), carboxyterminal propeptide of type I procollagen (PICP), and bone gla protein (BGP), in Japanese adult women. The bone mineral density (BMD) of the lumbar spine (L2-L4) and the serum levels of ICTP, PICP and BGP were determined in a total of 207 healthy Japanese women (108 premenopausal and 99 postmenopausal).The lumbar BMD decreased significantly with increasing age not only in postmenopausal women (P<0.001) but also in premenopausal women (P=0.014).There was a clear gap in the serum levels of ICTP, PICP and BGP between the premenopausal and postmenopausal group (P<0.001), but those were absolutely the same within each group except for ICTP in the postmenopausal women. These findings and the values of serum ICTP, PICP and BGP in pre-and postmenopausal women obtained in this study are expected to be very useful for treatment of postmenopausal osteoporosis.

show abstract

Section: Discussionsupporting

confidence: 86%

mentioning

confidence: 75%

See 1 more Smart Citation

Age-Related Changes in Bone Mineral Density and Serum Bone-Related Proteins in Premenopausal and Postmenopausal Japanese Women.

et al. 2000

Self Cite

View full text Add to dashboard Cite

show abstract

“…tially higher rate than the 1 to 2% loss per year noted after natural menopause (22). Although several studies have noted increased urinary excretion of bone resorption markers after surgical menopause (23,24), to our knowledge, no published studies have shown that women with surgical menopause have higher urinary calcium excretion compared with women with natural menopause. However, the higher rate of bone loss after surgical menopause likely reflects a higher urinary calcium excretion and could account for the increased risk of incident kidney stones we noted in this study.…”

Section: Discussionmentioning

confidence: 92%

“…The sudden loss of ovarian production of estrogens and androgens in women with surgical menopause leads to a more rapid bone loss compared with women with natural menopause (19 -21). Genant et al (24) noted a 7 to 9% decrease in vertebral bone mineral density during the first 2 yr after bilateral oophorectomy, a substan- b The multivariate-adjusted model included: age (1-yr intervals), body mass index (five categories), presence of hypertension (yes/no), age at menopause (1-yr intervals), supplemental calcium (0 mg/d, 1 to 100 mg/d, 101 to 500 mg/d, and Ͼ500 mg/d), alcohol consumption (eight categories), and quintiles of dietary intake of calcium, animal protein, potassium, sodium, sucrose, magnesium, vitamin B6, and total fluid. tially higher rate than the 1 to 2% loss per year noted after natural menopause (22).…”

Section: Discussionmentioning

confidence: 99%

Menopause and Postmenopausal Hormone Use and Risk of Incident Kidney Stones

Kramer¹,

Grodstein²,

Stampfer³

et al. 2003

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Abstract. Menopause is associated with increased urinary calcium excretion, which could increase the risk for the development of calcium-containing kidney stones. However, it is unknown whether menopause and postmenopausal hormone (PMH) use are independent risk factors for incident kidney stone disease in women. Data from 91,731 female Nurses' Health Study participants who provided information on diet, menopause status, and kidney stone disease were used to examine the independent association between menopause and PMH use and risk of incident kidney stones. No association was found between menopause and incident kidney stones in age-adjusted (relative risk [RR], 1.07; 95% CI, 0.85 to 1.34) or multivariate models (RR, 1.12; 95% CI, 0.89 to 1.41). However, when the association between the type of menopause and risk of incident kidney stones was examined, surgical menopause was associated with an increased risk in both the ageadjusted (RR, 1.37; 95% CI, 1.05 to 1.77) and multivariate models (RR, 1.39; 95% CI, 1.07 to 1.81), whereas natural menopause was not. Compared with never-use, past or current PMH use (including duration of PMH use) was not associated with incident kidney stones among postmenopausal women. In conclusion, no association was found between menopause and PMH use and incident kidney stones. Surgical menopause, however, may be associated with an increased risk.Approximately 5% of all women living in the United States will experience the passage of a kidney stone before the age of 70 yr (1). The passage of a kidney stone is very painful, and the costs incurred due to treatment, morbidity, and time lost from work are substantial (2). Increased urinary calcium excretion is an important risk factor for the development of calcium-containing kidney stones (3), which account for over 80% of all kidney stones in the United States (4). Compared with urinary calcium concentrations Ͻ 75 mg/L, the relative risk for kidney stones increased from twofold in subjects with urinary calcium 100 to 149 mg/L to over fourfold in subjects with Ն 200 mg/L (5). Thus, even moderate increases in urinary calcium excretion may substantially increase the risk for stone formation.Menopause is associated with an increase in urinary calcium excretion (6,7), which may increase the risk for calciumcontaining stone formation. In subjects matched for serum total and ionized calcium levels, urinary calcium excretion was 50% higher (P Ͻ 0.001) in postmenopausal women compared with premenopausal women (6). Thus, the onset of menopause may increase urinary calcium excretion and the risk for kidney stone formation. In contrast, postmenopausal hormone (PMH) use has been shown to decrease fasting urinary calcium by 50% compared with baseline in postmenopausal women (8). It is currently not known whether menopause and PMH use are independent risk factors for kidney stone formation in women. The aim of this study was to prospectively study the independent association among menopause, PMH use, and risk of incident kidney stones in women. Materia...

show abstract