Age-Related Changes in Bone Mineral Density and Serum Bone-Related Proteins in Premenopausal and Postmenopausal Japanese Women.

Yasumizu, Takehiko; Okuno, Takashi; Fukada, Yukihito; Hoshi, Kazuhiko

doi:10.1507/endocrj.47.103

Cited by 8 publications

(3 citation statements)

References 18 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the present study indicated that the levels of OC (P<0.01), PICP (P<0.05) and ICTP (P<0.01) were all increased in the OVX group. This may be due to the lack of estrogen resulting in hyperactivity in osteoclastic bone resorption and leading to a subsequent increase in bone resorption markers (39). Regardless of whether sCT and ASA were used alone or in combination, they were able to inhibit the high bone turnover observed in OVX rats; however, there was no significant difference between the effectiveness of the treatments, alone or in combination.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats

Wei

Wang

Gong

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

The objective of the present study was to assess the effectiveness of combined salmon calcitonin (sCT) and aspirin [acetylsalicylic acid (ASA)] treatment in an ovariectomized (OVX) rat model of postmenopausal osteoporosis. Following 12 weeks of treatment, therapeutic efficacy was assessed by evaluating changes in the biochemical and biophysical properties of bone (n=8 rats per group). Serological markers of bone metabolism were measured by ELISA; bone mineral densities (BMD) by dual energy X-ray absorptiometry; bone biomechanics of the femur and lumbar vertebrae by three-point stress test; trabecular bone morphology of lumbar vertebrae by hematoxylin and eosin staining; messenger RNA expression levels of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in bone marrow cells by reverse transcription-quantitative polymerase chain reaction and OPG and RANKL protein expression levels in the proximal tibia were analyzed by immunohistochemistry. Compared with treatment by sCT or ASA alone, combined treatment (sCT+ASA) increased BMD, improved femur bone strength, normalized trabecular network architecture and morphology, and increased mRNA and protein expression of OPG, while reducing the expression of RANKL. Collectively, these results demonstrated that combined treatment (sCT+ASA) of osteoporotic symptoms in OVX rats was more effective than treatment with sCT or ASA alone. Furthermore, these two drugs appeared to alter the expression of two distinct factors in the OPG/RANKL/RANK system, suggesting that their effects may be synergistic. Since sCT and ASA are currently approved for use in humans, the results of the present study suggest that the safety and efficacy of sCT+ASA combined therapy for postmenopausal osteoporosis should be assessed in clinical trials.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats

Wei

Wang

Gong

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Therefore, renal function was not considered to have affected the changes in any of the serum markers focused on in our study. ICTP differed between premenopausal and postmenopausal women, and the number of years after menopause was also associated with increasing ICTP . Age was associated with increasing serum TRACP‐5b activity in healthy women and increasing serum BAP in healthy men and women .…”

Section: Discussionmentioning

confidence: 91%

“…ICTP differed between premenopausal and postmenopausal women, and the number of years after menopause was also associated with increasing ICTP. 24 Age was associated with increasing serum TRACP-5b activity in healthy women 8 and increasing serum BAP in healthy men and women. 25 In our study, half of patients were male, while most of the women were likely postmenopausal, and so the effect of menopausal status on our results was considered limited.…”

Section: Discussionmentioning

confidence: 95%

Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study

Urakawa

Ando

Hase

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

Bone modifying agents (BMAs) have become a standard treatment to prevent skeletal-related events (SREs) in bone metastases (BMs). The aim of our study is to determine the clinical value of serum bone resorption markers for predicting clinical outcomes after using BMAs in patients with BM. Patients were enrolled between May 2013 and October 2017 at the Nagoya University Hospital, Japan. We prospectively observed changes in pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and tartrate-resistant acid phosphatase 5b (TRACP-5b) during treatment with BMAs. The relationship between serum markers before and after treatment and clinical outcomes such as progression of bone disease (BD), SREs and overall survival (OS) were evaluated. Pearson chi-square test and Kaplan-Meier product limit methods were used for analysis. Sixty-seven patients were analyzed. The primary tumor sites were 21 lung, 16 breast and 30 others. Forty and 27 patients were treated with Denosumab and Zoledronic acid, respectively. Progression of BDs, SREs and death were observed in 10, 16 and 31 cases, respectively. The median follow-up period after using BMAs was 12.3 (range 0.3-66.3) months. ICTP at 3-4 weeks was significantly correlated with increasing BD progression, SREs and death after treatment in both the whole and lung cancer cohorts. Base line ICTP and TRACP-5b were also associated with increasing BD progression in the whole cohort. Our study showed that early posttreatment ICTP is useful for predicting BD progression, SREs and OS after use of BMAs in patients with BM and even in patients with lung cancer BM.Additional Supporting Information may be found in the online version of this article.

show abstract

The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes

et al. 2011

View full text Add to dashboard Cite

Women exhibited a significant correlation between the Barthel score and the expression of long telomeres (>9.4 Kb), in contrast with men who revealed no such correlation. The physical ability of older women was positively correlated with the lengths of their somatic telomeres. Among the BI items, the scores of more difficult physical performances tended to correlate with the presence of terminal restriction fragments longer than 9.4 Kb.

show abstract

Age-Related Changes in Bone Mineral Density and Serum Bone-Related Proteins in Premenopausal and Postmenopausal Japanese Women.

Cited by 8 publications

References 18 publications

Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats

Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats

Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study

The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes

Contact Info

Product

Resources

About