Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma

Brianezi, Gabrielli; Handel, Ana Carolina; Schmitt, Juliano Vilaverde; Miot, Luciane Donida Bartoli; Miot, Hélio Amante

doi:10.1111/jdv.12453

Cited by 25 publications

(18 citation statements)

References 16 publications

(20 reference statements)

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“…Regarding the areas of photoexposed skin in melasma‐affected patients, different phenotypic expressions in the epidermal‐melanin unit were observed that superimposed in an intriguing way, suggesting the possibility of mosaic‐like focal changes . Factors involved in its development most likely act directly on melanogenesis and on the cytocrine activity of melanosomes, rather than a systemic change in which generalized pigmentation would be expected, such as that induced by ACTH administration in patients .…”

Section: Discussionmentioning

confidence: 99%

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Gene and protein expression of oestrogen‐β and progesterone receptors in facial melasma and adjacent healthy skin in women

Tamega

Miot

Moço

et al. 2014

Intern J of Cosmetic Sci

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Section: Discussionmentioning

confidence: 99%

“…Melanocytes from melasma‐affected skin are locally hyperfunctioning due to specific paracrine stimulus from melanogenic substances secreted by neighbour keratinocytes, influenced by environmental factors, such as ultraviolet radiation and sex steroid hormones .…”

Section: Discussionmentioning

confidence: 99%

Gene and protein expression of oestrogen‐β and progesterone receptors in facial melasma and adjacent healthy skin in women

Tamega

Miot

Moço

et al. 2014

Intern J of Cosmetic Sci

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“…Hingga saat ini patogenesisnya belum dapat dijelaskan sepenuhnya. [1][2][3] Belum banyak pula penelitian tentang karakter pewarisan genetik pada melasma yang berhubungan dengan warna kulit. [4][5][6][7] Warna kulit manusia ditentukan oleh jenis pigmen eumelanin dan pheomelanin yang diregulasi oleh gen melanocortin-1 receptor (MC1R) dan agouti signaling protein (ASIP), serta dipengaruhi oleh letak geografis tempat seseorang tersebut berasal.…”

Section: Pendahuluanunclassified

Melasma Dalam Sudut Pandang Genetik

Suryaningsih

2019

MDVI

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Melasma merupakan kelainan hiperpigmentasi pada wajah dan terdistribusi secara simetris. Lebihbanyak terjadi pada wanita usia reproduktif dan banyak terjadi pada seseorang dengan tipe kulit III-V.Melasma sering memberikan dampak negatif pada kualitas hidup pasien dalam hubungan sosial. Kelainanini sangat sulit diobati dan memerlukan biaya yang cukup mahal, namun sering tidak memuaskan baikbagi pasien maupun dokter yang menanganinya. Patogenesis melasma bersifat multifaktor dan belum dapatdijelaskan sepenuhnya. Faktor genetik, hormon, dan pajanan ultra-violet (UV) merupakan faktor risikomelasma. Dari semua faktor tersebut diduga faktor genetik dan pajanan matahari berperan utama dalampatogenesis melasma. Selain itu riwayat melasma dalam keluarga juga merupakan faktor risiko. Beberapapenelitian terbaru menemukan beberapa ekspresi gen dan melibatkan beberapa jalur yang berperan dalampatogenesis melasma. Gen melanocortin-1 receptor (MC1R) merupakan salah satu gen yang diduga berperansecara genetik pada melasma.Kata kunci: Melasma, genetik, hormonal, pajanan UV dan MC1-R

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“…It is mainly associated with sun exposure and sex steroids (pregnancy and oral contraceptives), with frequent family involvement (40-60%). 1-3 …”

Section: Introductionmentioning

confidence: 99%

Psychometrican analysis and dimensional structure of the Brazilian version of melasma quality of life scale (MELASQoL-BP)

Maranzatto

Miot

et al. 2016

An. Bras. Dermatol.

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BackgroundAlthough asymptomatic, melasma inflicts significant impact on quality of life. MELASQoL is the main instrument used to assess quality of life associated with melasma, it has been validated in several languages, but its latent dimensional structure and psychometric properties haven´t been fully explored.ObjectivesTo evaluate psychometric characteristics, information and dimensional structure of the Brazilian version of MELASQoL.MethodsSurvey with patients with facial melasma through socio-demographic questionnaire, DLQI-BRA, MASI and MELASQoL-BP, exploratory and confirmatory factor analysis, internal consistency of MELASQoL and latent dimensions (Cronbach's alpha). The informativeness of the model and items were investigated by the Rasch model (ordinal data).ResultsWe evaluated 154 patients, 134 (87%) were female, mean age (± SD) of 39 (± 8) years, the onset of melasma at 27 (± 8) years, median (p25-p75) of MASI scores , DLQI and MELASQoL 8 (5-15) 2 (1-6) and 30 (17-44). The correlation (rho) of MELASQoL with DLQI and MASI were: 0.70 and 0.36. Exploratory factor analysis identified two latent dimensions: Q1-Q3 and Q4-Q10, which had significantly more adjusted factor structure than the one-dimensional model: Χ2 / gl = 2.03, CFI = 0.95, AGFI = 0.94, RMSEA = 0.08. Cronbach's coefficient for the one-dimensional model and the factors were: 0.95, 0.92 and 0.93. Rasch analysis demonstrated that the use of seven alternatives per item resulted in no increase in the model informativeness.ConclusionsMELASQoL-BP showed good psychometric performance and a latent structure of two dimensions. We also identified an oversizing of item alternatives to characterize the aggregate information to each dimension.

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Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma

Abstract: Basal keratinocytes from facial melasma display changes in nuclear form and chromatin texture, suggesting that the phenotype differences between melasma and adjacent facial skin can result from complete epidermal melanin unit alterations, not just hypertrophic melanocytes.

Cited by 25 publications

References 16 publications

Gene and protein expression of oestrogen‐β and progesterone receptors in facial melasma and adjacent healthy skin in women

Gene and protein expression of oestrogen‐β and progesterone receptors in facial melasma and adjacent healthy skin in women

Melasma Dalam Sudut Pandang Genetik

Psychometrican analysis and dimensional structure of the Brazilian version of melasma quality of life scale (MELASQoL-BP)

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