Melasma Dalam Sudut Pandang Genetik

Suryaningsih, Betty Ekawati

doi:10.33820/mdvi.v46i3.75

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…If there is an increase of estrogen or progesteron level in the body so that will affect acceleration of melanogenesis. 7,8,12,13 Another mechanism is estrogen play a role to induce the growth of basal keratinocytes then will effects the proliferation of melanocytes, and tranfer of melanosomes that cause melasma. Melanosomes sythesized by melanocytes, melanosomes consist of cocoa bio-chroma that is melanin.…”

Section: Discussionmentioning

confidence: 99%

Melasma Show Up in Contraceptive Pills Acceptors

Azzahra

Widyawati

Afriliana

et al. 2021

DMJ

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Introduction : Melasma is one of the most common hyperpigmentation disorders among womans, the common hyperpigmentation patches which commonly found on face especially on sunlight exposured area. One of the factors causing melasma is the use of oral contraceptives which cause the buildup of the hormones estrogen and progesterone on the skin.Objectives : Thus, the aim of the study is to analyze the association between duration of contraceptive pills use and melasma.Methods : This study used a cross-sectional design. The research was conducted in May-July 2020. The subjects were 36 womans aged 30-55 years old and oral contraceptive acceptors that qualify inclussion criteria and not eligible exclussion criteria. The data was collected primarily using questionnaires. Physical examinations were done through observation with a photo of the respondents. Data analysis using the Chi Square test with a significance value p <0,05.Results : Based on the results of this study, the significance of 0.017 less than 0.05 which indicates a relationship between variables duration of contraceptive pills use and melasma. Conclusions : This study shows a association between duration of contraceptive pills use and melasmaKeywords : melasma, contraceptive pills.

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Section: Discussionmentioning

confidence: 99%

Melasma Show Up in Contraceptive Pills Acceptors

Azzahra

Widyawati

Afriliana

et al. 2021

DMJ

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“…This will increase the melanogenesis process. 17 Ultraviolet light exposure also causes lipid peroxidation of the cell membrane, leading to free radical formation. 15 This induces keratinocytes to release various cytokines, including α-melanocyte stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH).…”

Section: Discussionmentioning

confidence: 99%

The Profile and Triggering Factors of Melasma Patients: A Retrospective Study

Putri Brillian Betrista Viorizka,

Trisniartami Setyaningrum,

Ema Qurnianingsih

et al. 2023

BIKK

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Background: Melasma is a skin pigmentation disorder characterized by brownish hyperpigmented lesions with symmetrical distribution and irregular borders. It becomes a cosmetic problem that causes a negative impact on quality of life and a lack of confidence in patients. The etiology of melasma is not completely understood, but several factors that trigger melasma can be explained. Yet, the profile and triggering factors associated with the prevalence of melasma patients in Surabaya are still unexplored. Purpose: To determine the profile and triggering factors of melasma patients in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital Surabaya from January to December 2019. Methods: A retrospective descriptive study using data from medical records with a total sampling technique. Result: In this study, most of the melasma patients were female (97.5%), dominated by the age group 46-55 years (49.4%), and worked as housewives (40.74%). The triggering factors found in patients were sun exposure (96.3%), cosmetics (67.9%), hormonal (49.4%), and family history (22.2%). The physical examinations of melasma lesions showed that they were mostly located in the malar area (72.8%), light brown colored (74.7%), and 2.0 – 4.0 cm in size (54.3%). Wood’s lamp examination showed that most of the lesions had firm and indistinct borders (55.6%). Conclusion: The triggering factors of melasma are multifactorial, but we suspect that sun exposure plays an important role in affecting melasma.

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“…Respirasi dan metabolisme sebuah sel dibutuhkan oksigen dan besi dalam bentuk ferro (Fe 2+ ) yang diolah di dalam mitokondria untuk masuk ke dalam siklus krebs sehingga diubah menjadi energi untuk kelangsungan hidup sel dan jaringan. 27 Ketika terjadi defisiensi zat besi, maka tubuh mengkompensasi dengan meningkatkan daur ulang dengan cara pemecahan eritrosit dan cadangan besi. Eritrosit yang dipecah maka heme akan digunakan kembali, sedangkan pemecahan feritin sebagai cadangan besi terbesar dalam tubuh akan menyebabkan turunnya kadar feritin.…”

Section: Pembahasanunclassified

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita

Stephanie

Rusyati

Karna³

et al. 2022

Intisari Sains Medis

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Introduction: Melasma is an acquired pigmentation disorder characterized by symmetrical hyperpigmented patches, most commonly seen on the face. Melasma and iron deficiency are most common in women of reproductive age. Iron deficiency causes a decrease in ferritin levels, which are iron stores in the body. The mechanism of iron deficiency causing melasma is thought to be due to cell hypoxia in the tissue involving mediators that increase melanogenesis. This study aims to prove that the mean ferritin level is lower in melasma than without melasma and that low ferritin levels are a risk factor for melasma in women. Methods: A case-control research included 28 participants with melasma and 28 without melasma who visited the dermatovenereology department of Prof. Dr. I.G.N.G Ngoerah Hospital, medical cosmetic division, in May-July 2022. The two groups will compare ferritin mean and ferritin risk factor analysis on the incidence of melasma. Data were tabulated and analyzed using SPSS 26. Results: The mean age in the melasma group was 40.64±3.39 years old, and the group without melasma was 37.64±3.50 years old (p=0.75). Of the 28 melasma subjects, there were more subjects with low ferritin levels (60.7%) than the group without melasma (32.1%). From the results of the Mann-Whitney test, the mean ferritin level in the melasma group (36.32±31.05) was significantly lower than in the non-melasma group (58.26±5.39); p=0.006. From the results of the Chi-Square test, it was found that low ferritin levels had a risk of 3.2 times the occurrence of melasma [OR (95% CI) = 3.2 (1.098-9.776), p=0.032]. Conclusion: The mean ferritin level in women with melasma is lower than in women without melasma, and low ferritin levels are a risk factor for melasma. Latar Belakang: Melasma merupakan kelainan pigmentasi didapat yang ditandai dengan adanya bercak hiperpigmentasi simetris, paling sering terlihat pada wajah. Melasma dan defisiensi besi paling sering dijumpai pada wanita usia reproduktif. Defisiensi besi menyebabkan turunnya kadar feritin yang merupakan cadangan besi dalam tubuh. Mekanisme defisiensi zat besi menyebabkan melasma diduga akibat hipoksia sel di dalam jaringan melibatkan mediator yang meningkatkan melanogenesis. Studi ini bertujuan untuk membuktikan rerata kadar feritin lebih rendah pada melasma dibandingkan tanpa melasma serta membuktikan kadar feritin yang rendah merupakan faktor risiko melasma pada wanita. Metode: Studi case-control yang melibatkan 28 subjek dengan melasma dan 28 subjek tanpa melasma yang berobat ke poliklinik kulit dan kelamin RSUP Prof. Dr. I.G.N.G Ngoerah divisi kosmetik medik periode Mei-Juli 2022. Kedua kelompok akan dibandingkan rerata feritin dan analisis faktor risiko feritin terhadap kejadian melasma. Data ditabulasi dan dianalisis dengan menggunakan SPSS 26. Hasil: Rerata usia pada kelompok melasma 40.64±3,39 tahun dan kelompok tanpa melasma 37,64±3,50 tahun (p=0,75). Dari 28 subjek melasma, didapatkan lebih banyak subjek dengan kadar feritin rendah (60,7%) dibandingkan kelompok tanpa melasma (32,1%). Dari hasil uji Mann-Whitney didapatkan rerata kadar feritin pada kelompok melasma (36,32±31,05) lebih rendah secara signifikan dibandingkan pada kelompok bukan melasma (58,26±5,39); p=0,006. Dari hasil uji Chi-Square didapatkan kadar feritin yang rendah memiliki risiko sebesar 3,2 kali terjadinya melasma [OR (IK 95%) =3,2 (1,098-9,776), p=0,032]. Simpulan: rerata kadar feritin pada wanita dengan melasma lebih rendah dibandingkan wanita tanpa melasma dan kadar feritin yang rendah merupakan faktor risiko melasma.

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Melasma Dalam Sudut Pandang Genetik

Cited by 3 publications

References 17 publications

Melasma Show Up in Contraceptive Pills Acceptors

Melasma Show Up in Contraceptive Pills Acceptors

The Profile and Triggering Factors of Melasma Patients: A Retrospective Study

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita

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