Cephalosporin C production in a stirred tank reactor

Abstract

Summary. Cephalosporin C was produced with the mold Cephalosporium acremonium in a 20 1 stirred tank reactor with 100 kg/m 3 peanut flour in fed-batch operation. The growth and product formation was followed by on-line analysis of the broth composition. The cell concentration was estimated from the RNA-content of the cells. By optimization of the fed-batch operation and by increasing the phosphate content in the broth, a final cephalosporin C concentration of 12 k g / m 3 was attained.

Swainsonine production in fed-batch fermentations of Metarhizium anisopliae

“…It has been extensively used both in small-scale research (Marquet et al, 1989;Herold et al, 1988;and Fiedler et al, 1985) and also in industrial-scale production of many commercially important metabolites. Feeding strategies have been used not only to enhance titres and extend the duration of production directly, but also to improve culture homogeneity through reduction of viscosity.…”